Persistent extrasynaptic hyperdopaminergia in the mouse hippocampus induces plasticity and recognition memory deficits reversed by the atypical antipsychotic sulpiride.

Autor: Jill Rocchetti, Caroline Fasano, Gregory Dal-Bo, Elisa Guma, Salah El Mestikawy, Tak-Pan Wong, Gohar Fakhfouri, Bruno Giros

Publikováno v: PLoS ONE, Vol 18, Iss 8, p e0289770 (2023)

Evidence suggests that subcortical hyperdopaminergia alters cognitive function in schizophrenia and antipsychotic drugs (APD) fail at rescuing cognitive deficits in patients. In a previous study, we showed that blocking D2 dopamine receptors (D2R), a

Externí odkaz: https://doaj.org/article/e5939b5f668948ee879005b81439a6ea

How to detect and track chronic neurologic sequelae of COVID-19? Use of auditory brainstem responses and neuroimaging for long-term patient follow-up

Autor: Michael Ogier, Guillaume Andéol, Emmanuel Sagui, Gregory Dal Bo

Publikováno v: Brain, Behavior, & Immunity - Health, Vol 5, Iss , Pp 100081- (2020)

This review intends to provide an overview of the current knowledge on neurologic sequelae of COVID-19 and their possible etiology, and, based on available data, proposes possible improvements in current medical care procedures. We conducted a thorou

Externí odkaz: https://doaj.org/article/e1d2bdcf26794f61bef83d9599db913f

Persistent Extrasynaptic Hyperdopaminergia in the mouse Hippocampus Induces Plasticity and Recognition Memory Deficits Reversed by Antipsychotics

Autor: Jill Rocchetti, Caroline Fasano, Gregory Dal-Bo, Elisa Guma, Salah El Mestikawy, Tak Pan Wong, Gohar Fakhfouri, Bruno Giros

Evidence suggests that subcortical hyperdopaminergia alters cognitive function in schizophrenia and antipsychotic drugs (APD) fail at rescuing cognitive deficits in patients. In a previous study, we showed that blocking D2 dopamine receptors (D2R), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64d34963b1dca0c080220fa77166348e
https://doi.org/10.1101/2023.01.12.523788

Persistent brainwave disruption and cognitive impairment induced by acute sarin surrogate sub-lethal dose exposure

Autor: Bruno Mégarbane, Quentin Gerard, Chloe Cervera, Rachid Baati, Loïc Angrand, Karine Thibault, Julie Knoertzer, Rosalie Bel, Samir Takillah, Joseph P. Kononchik, Gregory Dal Bo, Isabelle Malissin, Asma Berriche

Publikováno v: Toxicology
Toxicology, 2021, 456, pp.152787. ⟨10.1016/j.tox.2021.152787⟩

International audience; Warfare neurotoxicants such as sarin, soman or VX, are organophosphorus compounds which irreversibly inhibit cholinesterase. High-dose exposure with nerve agents (NA) is known to produce seizure activity and related brain dama

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c47a6b124cca8e7a0302d82e031a946
https://pubmed.ncbi.nlm.nih.gov/33887375

Organophosphorus diisopropylfluorophosphate (DFP) intoxication in zebrafish larvae causes behavioral defects, neuronal hyperexcitation and neuronal death

Autor: Florian Nachon, Nicolas Taudon, Olivier Bar, Nina Dupuis, Julie Somkhit, Christiane Romain, Dominique Saurat, Alexandre Igert, Rahma Hassan-Abdi, Gregory Dal-Bo, Constantin Yanicostas, Nadia Soussi-Yanicostas, Alexandre Brenet

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.19228. ⟨10.1038/s41598-020-76056-8⟩
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-76056-8⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)

With millions of intoxications each year and over 200,000 deaths, organophosphorus (OP) compounds are an important public health issue worldwide. OP poisoning induces cholinergic syndrome, with respiratory distress, hypertension, and neuron damage th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428dc1f43f3c0d59107abba0cc8d4a56
https://www.hal.inserm.fr/inserm-03058521