Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gregory D McCluskey"'
Autor:
Christian JG Tessier, Raymond M Sturgeon, Johnathon R Emlaw, Gregory D McCluskey, F Javier Pérez-Areales, Corrie JB daCosta
Publikováno v:
eLife, Vol 11 (2022)
Human adult muscle-type acetylcholine receptors are heteropentameric ion channels formed from two α-subunits, and one each of the β-, δ-, and ε-subunits. To form functional channels, the subunits must assemble with one another in a precise stoich
Externí odkaz:
https://doaj.org/article/7d82829b541748b58e568c519c9787e2
Autor:
Matthew J. McLeod, Norman Tran, Gregory D. McCluskey, Tom D. Gillis, Stephen L. Bearne, Todd Holyoak
Publikováno v:
Protein Science. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abf3d90dbca1102aa2ffe733e75824b5
https://doi.org/10.1002/pro.4648
https://doi.org/10.1002/pro.4648
Autor:
Christian J. G. Tessier, R. Michel Sturgeon, Johnathon R. Emlaw, Gregory D. McCluskey, F. Javier Pérez-Areales, Corrie J. B. daCosta
Human adult muscle-type acetylcholine receptors are heteropentameric ion channels formed from two α-subunits, and one each of the β-, δ-, and ε-subunits. To form functional channels, the subunits must assemble with one another in a precise stoich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6506b3634d20cd242638f81ed6e9d1ed
https://doi.org/10.1101/2022.01.12.475990
https://doi.org/10.1101/2022.01.12.475990
Autor:
Maria Musgaard, Christian J.G. Tessier, Gregory D. McCluskey, Kelly M. Burkett, Johnathon R. Emlaw, Corrie J.B. daCosta, Melissa McNulty, Yusuf Sheikh
Publikováno v:
Proc Natl Acad Sci U S A
Human adult muscle-type acetylcholine receptors are heteropentameric ion channels formed from four different, but evolutionarily related, subunits. These subunits assemble with a precise stoichiometry and arrangement such that two chemically distinct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5042582f4ad9c44e8445e6fbe7e2d842
https://doi.org/10.1073/pnas.2018731118
https://doi.org/10.1073/pnas.2018731118
Publikováno v:
The Febs Journal
Inosine monophosphate dehydrogenase (IMPDH) and cytidine triphosphate synthase (CTPS) are two metabolic enzymes that perform rate‐limiting steps in the de novo synthesis of purine and pyrimidine nucleotides, respectively. It has been shown that IMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f991d7d45fe0db5faf39882b3b8953
https://doi.org/10.1111/febs.14658
https://doi.org/10.1111/febs.14658
Publikováno v:
Organicbiomolecular chemistry. 17(37)
A rational approach that may be applied to a broad class of enzyme-catalyzed reactions to design enzyme inhibitors affords a powerful strategy, facilitating the development of drugs and/or molecular probes of enzyme mechanisms. A strategy for the dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d02046aa37d8f4fdfec366b5e7c325c
https://pubmed.ncbi.nlm.nih.gov/31528932
https://pubmed.ncbi.nlm.nih.gov/31528932
Publikováno v:
ChemBioChem. 17:2240-2249
CTP synthase (CTPS) catalyzes the conversion of UTP to CTP and is a target for the development of antiviral, anticancer, antiprotozoal, and immunosuppressive agents. Exposure of cell lines to the antineoplastic cytidine analogue gemcitabine causes de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31a9453d0f4cbc783432284a77e97f6
https://doi.org/10.1002/cbic.201600405
https://doi.org/10.1002/cbic.201600405
Publikováno v:
Biochimica et biophysica acta. General subjects. 1862(12)
Molecular gates within enzymes often play important roles in synchronizing catalytic events. We explored the role of a gate in cytidine-5'-triphosphate synthase (CTPS) from Escherichia coli. This glutamine amidotransferase catalyzes the biosynthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68a58f14c041524ae3c8b6f758e827f
https://pubmed.ncbi.nlm.nih.gov/30251661
https://pubmed.ncbi.nlm.nih.gov/30251661
Publikováno v:
Journal of molecular biology. 430(8)
While enzyme activity is often regulated by a combination of substrate/effector availability and quaternary structure, many cytosolic enzymes may be further regulated through oligomerization into filaments. Cytidine-5'-triphosphate (CTP) synthase (CT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706ce70d4e9a68188e9b2a70ef3ec088
https://pubmed.ncbi.nlm.nih.gov/29501573
https://pubmed.ncbi.nlm.nih.gov/29501573