Výsledky vyhledávání - "Gregory D Longmore"

Akademický článek

DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs

Autor: Samantha VH Bayer, Whitney R Grither, Audrey Brenot, Priscilla Y Hwang, Craig E Barcus, Melanie Ernst, Patrick Pence, Christopher Walter, Amit Pathak, Gregory D Longmore

Publikováno v: eLife, Vol 8 (2019)

Biomechanical changes in the tumor microenvironment influence tumor progression and metastases. Collagen content and fiber organization within the tumor stroma are major contributors to biomechanical changes (e., tumor stiffness) and correlated with

Externí odkaz: https://doaj.org/article/eab383b9c0cb49e7be6e667bc5b80fbf

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Akademický článek

Disruption of the Cdc42/Par6/aPKC or Dlg/Scrib/Lgl Polarity Complex Promotes Epithelial Proliferation via Overlapping Mechanisms.

Autor: Gregory V Schimizzi, Meghan T Maher, Andrew J Loza, Gregory D Longmore

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159881 (2016)

The establishment and maintenance of apical-basal polarity is a defining characteristic and essential feature of functioning epithelia. Apical-basal polarity (ABP) proteins are also tumor suppressors that are targeted for disruption by oncogenic viru

Externí odkaz: https://doaj.org/article/c5b64846b26d4fb88a9dccacf92fd792

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Akademický článek

Action of SNAIL1 in Cardiac Myofibroblasts Is Important for Cardiac Fibrosis following Hypoxic Injury.

Autor: Hirak Biswas, Gregory D Longmore

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0162636 (2016)

Hypoxic injury to the heart results in cardiac fibrosis that leads to cardiac dysfunction and heart failure. SNAIL1 is a zinc finger transcription factor implicated in fibrosis following organ injury and cancer. To determine if the action of SNAIL1 c

Externí odkaz: https://doaj.org/article/cdd7d645f6dd4fa2ad25b148f9296522

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Akademický článek

Functional analysis of recurrent CDC20 promoter variants in human melanoma

Autor: Paula M. Godoy, Abimbola Oyedeji, Jacqueline L. Mudd, Vasilios A. Morikis, Anna P. Zarov, Gregory D. Longmore, Ryan C. Fields, Charles K. Kaufman

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)

Abstract Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate oncogenic gene regulatory networks. Melanoma is heavily burdened by non-coding varia

Externí odkaz: https://doaj.org/article/74b900f059654a8b8f4f21f8c7bb487d

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Akademický článek

Genetic characterization of primary and metastatic high-grade serous ovarian cancer tumors reveals distinct features associated with survival

Autor: Emilee N. Kotnik, Mary M. Mullen, Nicholas C. Spies, Tiandao Li, Matthew Inkman, Jin Zhang, Fernanda Martins-Rodrigues, Ian S. Hagemann, Carolyn K. McCourt, Premal H. Thaker, Andrea R. Hagemann, Matthew A. Powell, David G. Mutch, Dineo Khabele, Gregory D. Longmore, Elaine R. Mardis, Christopher A. Maher, Christopher A. Miller, Katherine C. Fuh

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)

Abstract High-grade serous ovarian cancer (HGSC) is the most lethal histotype of ovarian cancer and the majority of cases present with metastasis and late-stage disease. Over the last few decades, the overall survival for patients has not significant

Externí odkaz: https://doaj.org/article/12406fa62eb94e7ab6b8f750b0d58be6

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Akademický článek

Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity

Publikováno v: Cell Reports, Vol 35, Iss 3, Pp 109009- (2021)

Summary: Cancer cells function as primary architects of the tumor microenvironment. However, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneit

Externí odkaz: https://doaj.org/article/2c651979e55c43638647e4def6c85ef2

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Data from Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues

Autor: Steven C. George, Gregory D. Longmore, Ashley C. King, Audrey Brenot, Priscilla Y. Hwang

Collective cell migration is an adaptive, coordinated interactive process involving cell–cell and cell–extracellular matrix (ECM) microenvironmental interactions. A critical aspect of collective migration is the sensing and establishment of direc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59deb6821fcb0f38b1c0ce31e440c49a
https://doi.org/10.1158/0008-5472.c.6511347.v1

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