Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Gregory D, Jay"'
Autor:
Leon Zhao, Alisa Vidwans, Courtney J. Bearnot, James Rayner, Timmy Lin, Janette Baird, Selim Suner, Gregory D. Jay
Publikováno v:
PLoS ONE, Vol 19, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/21d977159d17445784a8834e75af4498
Autor:
Nabangshu Das, Luiz G. N. de Almeida, Afshin Derakhshani, Daniel Young, Kobra Mehdinejadiani, Paul Salo, Alexander Rezansoff, Gregory D. Jay, Christian P. Sommerhoff, Tannin A. Schmidt, Roman Krawetz, Antoine Dufour
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Altered expression and function of the extracellular matrix protein PRG4 have been associated with osteoarthritis. Here, the authors show that mast cell tryptase β cleaves PRG4, resulting in a reduction of lubrication and activation of inflammation
Externí odkaz:
https://doaj.org/article/acd1e0dd071f4882af74316106133957
Autor:
Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Tannin A. Schmidt, Jennifer Totonchy, Khaled A. Elsaid
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-16 (2021)
Abstract Background Synovial macrophages perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune surveillance, and resolution of inflammation. The functional diversity of macrophages is enabled by dist
Externí odkaz:
https://doaj.org/article/8f90a6074da94b92a1e702e643c15732
Autor:
Yun Jin Ashley Sin, Rebecca MacLeod, Adam P. Tanguay, Andrew Wang, Olivia Braender-Carr, Teraesa M. Vitelli, Gregory D. Jay, Tannin A. Schmidt, Mary K. Cowman
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The size, conformation, and organization of the glycosaminoglycan hyaluronan (HA) affect its interactions with soluble and cell surface-bound proteins. HA that is induced to form stable networks has unique biological properties relative to unmodified
Externí odkaz:
https://doaj.org/article/3f4e77d45968469ea3503c7bc629f2b0
Autor:
Shan Huang, Kristina A. Thomsson, Chunsheng Jin, Henrik Ryberg, Nabangshu Das, André Struglics, Ola Rolfson, Lena I. Björkman, Thomas Eisler, Tannin A. Schmidt, Gregory D. Jay, Roman Krawetz, Niclas G. Karlsson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The primary aim of the study was to identify inflammatory markers relevant for osteoarthritis (OA)-related systemic (plasma) and local (synovial fluid, SF) inflammation. From this, we looked for inflammatory markers that coincided with the increased
Externí odkaz:
https://doaj.org/article/6b701682bbad4a48b68b04253d62c085
Autor:
Nabangshu Das, Nikhil G. Menon, Luiz G. N. de Almeida, Paige S. Woods, Miriam L. Heynen, Gregory D. Jay, Barbara Caffery, Lyndon Jones, Roman Krawetz, Tannin A. Schmidt, Antoine Dufour
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Sjogren’s syndrome (SS) is characterized by dysfunctional mucous membranes and dysregulated moisture-secreting glands resulting in various symptoms, including dry mouth and dry eyes. Here, we wanted to profile and compare the tear and saliva proteo
Externí odkaz:
https://doaj.org/article/ea610b274d034bbd8e65ca465bd64bfd
Autor:
Sandy ElSayed, Gregory D. Jay, Ralph Cabezas, Marwa Qadri, Tannin A. Schmidt, Khaled A. Elsaid
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
ObjectivesTo compare phagocytic activities of monocytes in peripheral blood mononuclear cells (PBMCs) from acute gout patients and normal subjects, examine monosodium urate monohydrate (MSU) crystal-induced IL-1β secretion ± recombinant human prote
Externí odkaz:
https://doaj.org/article/a5f5059e5b304849a44c791b529ffdcc
Autor:
Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Holly Richendrfer, Tannin A. Schmidt, Khaled A. Elsaid
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-16 (2020)
Abstract Background Synovial tissue fibrosis is common in advanced OA with features including the presence of stress fiber-positive myofibroblasts and deposition of cross-linked collagen type-I. Proteoglycan-4 (PRG4) is a mucinous glycoprotein secret
Externí odkaz:
https://doaj.org/article/5dd97d15ec474874a9a0dbc67ead04e1
Autor:
Nikhil G. Menon, Yasir Suhail, Ruchi Goyal, Wenqiang Du, Adam P. Tanguay, Gregory D. Jay, Mallika Ghosh, Kshitiz, Tannin A. Schmidt
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 12711 (2022)
Dry Eye Disease (DED) is a complex pathology affecting millions of people with significant impact on quality of life. Corneal inflammation, including via the nuclear factor kappa B (NFκB) pathway, plays a key etiological role in DED. Recombinant hum
Externí odkaz:
https://doaj.org/article/d1ba189c137b4437a1458cbe983843c0
Autor:
Daniel S. Yang, Edward E. Dickerson, Ling X. Zhang, Holly Richendrfer, Padmini N. Karamchedu, Gary J. Badger, Tannin A. Schmidt, Alger M. Fredericks, Khaled A. Elsaid, Gregory D. Jay
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4245 (2022)
Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome leads to diarthrodial joint arthropathy and is caused by the absence of lubricin (proteoglycan 4—PRG4), a surface-active mucinous glycoprotein responsible for lubricating articular ca
Externí odkaz:
https://doaj.org/article/85f96f20357b4654ab75d7fd69d9026b