Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gregory C. Sartor"'
Publikováno v:
Advances in Drug and Alcohol Research. 2
Although noncoding RNAs (ncRNAs) have been shown to regulate maladaptive neuroadaptations that drive compulsive drug use, ncRNA-targeting therapeutics for substance use disorder (SUD) have yet to be clinically tested. Recent advances in RNA-based dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b07a734a4aff89296efcf5296605af9
https://doi.org/10.3389/adar.2022.10807
https://doi.org/10.3389/adar.2022.10807
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 47(8)
Innovative breakthroughs in nanotechnology are having a substantial impact in healthcare, especially for brain diseases where effective therapeutic delivery systems are desperately needed. Nanoparticle delivery systems offer an unmatched ability of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a5798251485c335fa88c4e7e8243e83
https://pubmed.ncbi.nlm.nih.gov/35351961
https://pubmed.ncbi.nlm.nih.gov/35351961
Publikováno v:
Behav Brain Res
Epigenetic mechanisms play important roles in the neurobiology of substance use disorder. In particular, bromodomain and extra-terminal domain (BET) proteins, a class of histone acetylation readers, have been found to regulate cocaine conditioned beh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16c48aace8b567a81e67e947653b71c
https://doi.org/10.1016/j.bbr.2021.113644
https://doi.org/10.1016/j.bbr.2021.113644
Autor:
Michelle Meiqi Bao, Gregory C. Sartor, Claes Wahlestedt, Derek M. Dykxhoorn, Jianqin Wei, Chunming Dong, Wei Zhu, Clay T. Pierce, Huilan Wang
Publikováno v:
Hypertension. 71:752-760
Cocaine abuse increases the risk of cardiovascular mortality and morbidity; however, the underlying molecular mechanisms remain elusive. By using a mouse model for cocaine abuse/use, we found that repeated cocaine injection led to increased blood pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::469b9e8ea92218311dc12a962530638f
https://doi.org/10.1161/hypertensionaha.117.10213
https://doi.org/10.1161/hypertensionaha.117.10213
Autor:
Gregory C. Sartor
Publikováno v:
Biochem Pharmacol
Identifying novel therapeutics for the treatment of substance use disorder (SUD) is an area of intensive investigation. Prior strategies that have attempted to modify one or a few neurotransmitter receptors have had limited success, and currently the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6fef76787ab2a20955c60bc8bd4d78
https://pubmed.ncbi.nlm.nih.gov/31306644
https://pubmed.ncbi.nlm.nih.gov/31306644
Autor:
Mandakini B. Singh, Gregory C. Sartor
Publikováno v:
Neuropharmacology
Epigenetic pharmacotherapy for CNS-related diseases is a burgeoning area of research. In particular, members of the bromodomain and extra-terminal domain (BET) family of proteins have emerged as intriguing therapeutic targets due to their putative in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642f81d68aba99fa5ffef4ce236267b0
https://doi.org/10.1016/j.neuropharm.2020.108306
https://doi.org/10.1016/j.neuropharm.2020.108306
Autor:
Mohammad Ali Faghihi, Dmitry Velmeshev, Madina Makhmutova, Claude-Henry Volmar, Gregory C. Sartor, Claes Wahlestedt, Prutha Patel, Marco Magistri
Publikováno v:
Current Alzheimer Research
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by well-defined neuropathological brain changes including amyloid plaques, neurofibrillary tangles and the presence of chronic neuroinflammation. Objective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40aa1064c771438825ee61311a49b5d5
https://doi.org/10.2174/1567205013666160427101832
https://doi.org/10.2174/1567205013666160427101832
Autor:
Karolina J. Janczura, Claude-Henry Volmar, Gregory C. Sartor, Sunil J. Rao, Natalie R. Ricciardi, Guerline Lambert, Shaun P. Brothers, Claes Wahlestedt
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance With the imminent increase of the elderly population worldwide, Alzheimer’s disease (AD) is one of the most significant medical problems in modern society. Although nonselective histone deacetylase (HDAC) proteins delineate a promising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2226678aa8dfe1aa43487afb4978fe
https://doi.org/10.1073/pnas.1805436115
https://doi.org/10.1073/pnas.1805436115
Autor:
Claude-Henry Volmar, Karolina J. Janczura, Guerline Lambert, Hasib Salah-Uddin, Paul Halley, Gregory C. Sartor, Shaun P. Brothers, Claes Wahlestedt
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::083b332add0341660a09e6a4dc6ca211
https://doi.org/10.1016/j.jalz.2018.07.041
https://doi.org/10.1016/j.jalz.2018.07.041
Autor:
Claude-Henry Volmar, Hasib Salah-Uddin, Karolina J. Janczura, Paul Halley, Guerline Lambert, Andrew Wodrich, Sivan Manoah, Nidhi H. Patel, Gregory C. Sartor, Neil Mehta, Nancy T. H. Miles, Sachi Desse, David Dorcius, Michael D. Cameron, Shaun P. Brothers, Claes Wahlestedt
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Hundreds of failed clinical trials with Alzheimer’s disease (AD) patients over the last fifteen years demonstrate that the one-target–one-disease approach is not effective in AD. In silico, structure-based, multitarget drug design ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c50407444a518ddbd6df4f5ba402bdd
https://doi.org/10.1073/pnas.1707544114
https://doi.org/10.1073/pnas.1707544114