Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gregory C. Houghton"'
Autor:
Yevgeniya I. Orlovsky, Nicole Stowell, Anuk M. Das, David D. Christ, Kimberly A. Solomon, Dean A. Wacker, Douglas G. Batt, Lori L. Bostrom, Danielle M. Graden, Soo S. Ko, Erin McLaughlin, Carl P. Decicco, Gregory C. Houghton, Eric A. Wadman, Swamy Yeleswaram, Ilona Kariv, Percy H. Carter, Patricia K. Welch, Jeffrey G. Varnes, Robert C. Newton, Maryanne B. Covington, Paul Davies, James R. Pruitt, Shon K. Booker, Krishna Vaddi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2992-2997
DPC168, a benzylpiperidine-substituted aryl urea CCR3 antagonist evaluated in clinical trials, was a relatively potent inhibitor of the 2D6 isoform of cytochrome P-450 (CYP2D6). Replacement of the cyclohexyl central ring with saturated heterocycles p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1dd9c1a66cffc3a8a13b4d5ed114b4
https://doi.org/10.1016/j.bmcl.2007.03.065
https://doi.org/10.1016/j.bmcl.2007.03.065
Autor:
Patricia P Harlow, Susan M. Spitz, Mark S. Forsythe, Ruth R. Wexler, Martha H. Corjay, Joseph J. Petraitis, Peter J. Bouchard, Gregory C. Houghton, Shaker A. Mousa, Prabhakar K. Jadhav, Frank A. Barbera, Douglas G. Batt, Dilip P. Modi, Gary A. Cain
Publikováno v:
Journal of Medicinal Chemistry. 43:41-58
A new series of indazole-containing αvβ3 integrin antagonists is described. Starting with lead compound 18a, variations in a number of structural features were explored with respect to inhibition of the binding of β3-transfected 293 cells to fibri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cb1e0dfb66424a070cd1095d9734008
https://doi.org/10.1021/jm990049j
https://doi.org/10.1021/jm990049j
Autor:
James W. Jetter, James M. Trzaskos, Ronald L. Magolda, Pitts William J, Shuaige Wang, Michael J. Orwat, Susan R. Sherk, Gregory C. Houghton, Maryanne B. Covington, Douglas G. Batt, Donald J. P. Pinto, Joseph J. Petraitis, Robert A. Copeland
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:919-924
The discovery of terphenyl derivatives as highly selective COX-2 inhibitors resulted from our efforts to overcome poor pharmacokinetics demonstrated by the COX-2 selective diarylthiophene DuP 697 [2-bromo-4-(4′-sulfonylmethyl)phenyl-5-(4′-fluoro)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42f5431172ab404f5a0407fdebf3d65
https://doi.org/10.1016/s0960-894x(99)00105-5
https://doi.org/10.1016/s0960-894x(99)00105-5
Autor:
Linda M. Mascavage, Gregory C. Houghton, Kimberley Sanford, Mary McCoy, Alfred Findeisen, John Tierney, James Kilburn
Publikováno v:
Magnetic Resonance in Chemistry. 34:573-576
Substituents placed on the phenyl rings of 2,3-diphenyl-1,3-thiazolidin-4-one affect the electron density surrounding both the methine proton and the C(2) carbon. These changes are reflected in the differing chemical shifts for these atoms relative t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06a5dac5a19cd3dc9a835c3d950c1f9c
https://doi.org/10.1002/(sici)1097-458x(199608)34:8<573::aid-omr928>3.0.co
https://doi.org/10.1002/(sici)1097-458x(199608)34:8<573::aid-omr928>3.0.co
Publikováno v:
Tetrahedron Letters. 36:9261-9264
N -(1-substituent-1 11 -pyrrol-2-yl)phlhalimides can be used to prepare the previously unknown 2-aminopyrrole and 1-substituted 2-aminopyrroles which undergo fast proton exchange at C-5 in acetic acid at 25 °C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9694c9a959bbaf36a6b594bb31ab4f6e
https://doi.org/10.1016/0040-4039(95)02019-l
https://doi.org/10.1016/0040-4039(95)02019-l
Autor:
Douglas Guy Batt, Gregory C. Houghton
Publikováno v:
Journal of Heterocyclic Chemistry. 32:963-969
Nitroacetamidine undergoes a useful cyclocondensation with β-diketones to produce substituted 2-amino-3-nitropyridines. Use of an acylpyruvate generates hitherto unreported 2-amino-3-nitropyridine-4-carboxylates. These may be converted easily to fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c120625fc7226ce3cb06753413df276
https://doi.org/10.1002/jhet.5570320349
https://doi.org/10.1002/jhet.5570320349
Autor:
Douglas Guy Batt, Gregory C. Houghton
Publikováno v:
ChemInform. 26
Nitroacetamidine undergoes a useful cyclocondensation with β-diketones to produce substituted 2-amino-3-nitropyridines. Use of an acylpyruvate generates hitherto unreported 2-amino-3-nitropyridine-4-carboxylates. These may be converted easily to fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53b5aa7c875686d8a8d611c62db39918
https://doi.org/10.1002/chin.199545180
https://doi.org/10.1002/chin.199545180
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a834abb3d324e23bb731e5eff0336f9
https://doi.org/10.1002/chin.199615132
https://doi.org/10.1002/chin.199615132
Autor:
Joseph M. Luettgen, Prabhakar K. Jadhav, Gregory C. Houghton, Robert M. Knabb, Dilip P. Modi, Deborah A. Pierson, Douglas G. Batt, Jennifer X. Qiao, Karen A. Rossi, Ruth R. Wexler
Publikováno v:
ChemInform. 36
Structural features of a 5-amidinoindole inhibitor of factor Xa, which displayed modest inhibition of factor IXa were varied to increase potency and improve selectivity for factor IXa.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53285ea5f549abde5b87a94d32d7da56
https://doi.org/10.1002/chin.200508114
https://doi.org/10.1002/chin.200508114
Autor:
Dean A. Wacker, James M. Trzaskos, Gregory C. Houghton, Carl P. Decicco, Percy H. Carter, Patricia K. Welch, Douglas G. Batt, Eric A. Wadman, John Roderick, Paul Davies, Yevgeniya I. Orlovsky, Joseph B. Santella
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(3)
The synthesis and structure-activity relationships of N-arylalkylpiperidylmethyl ureas as antagonists of the CC chemokine receptor-3 (CCR3) are presented. These compounds displayed potent binding to the receptor as well as functional antagonism of eo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eadac300a6542f087d87ed375a42dcb
https://pubmed.ncbi.nlm.nih.gov/15664858
https://pubmed.ncbi.nlm.nih.gov/15664858