Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Gregory C. Davenport"'
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Akademický článek
Reduced Parasite Burden in Children with Falciparum Malaria and Bacteremia Coinfections: Role of Mediators of Inflammation
Autor: Gregory C. Davenport, James B. Hittner, Vincent Otieno, Zachary Karim, Harshini Mukundan, Paul W. Fenimore, Nicolas W. Hengartner, Benjamin H. McMahon, Prakasha Kempaiah, John M. Ong’echa, Douglas J. Perkins
Publikováno v: Mediators of Inflammation, Vol 2016 (2016)
Bacteremia and malaria coinfection is a common and life-threatening condition in children residing in sub-Saharan Africa. We previously showed that coinfection with Gram negative (G[−]) enteric Bacilli and Plasmodium falciparum (Pf[+]) was associat
Externí odkaz: https://doaj.org/article/ea5dde96b7d34d9da89cc09e5348c31a
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2
Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia
Autor: John M. Vulule, Samuel B. Anyona, James B. Hittner, Prakasha Kempaiah, Douglas J. Perkins, John M. Ong’echa, Gregory C. Davenport
Publikováno v: Biochemical and Biophysical Research Communications. 436:585-590
In holoendemic Plasmodium falciparum transmission regions, malarial anemia is a leading cause of childhood morbidity and mortality. Identifying biomarkers of malaria disease severity is important for identifying at-risk groups and for improved unders
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b441b35cd97efde5ce7295bf5fe21a
https://doi.org/10.1016/j.bbrc.2013.05.089
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3
Reduced Parasite Burden in Children with Falciparum Malaria and Bacteremia Coinfections: Role of Mediators of Inflammation
Autor: Benjamin H. McMahon, Douglas J Perkins, Zachary Karim, Vincent Otieno, Nicolas W. Hengartner, Paul W. Fenimore, Gregory C. Davenport, James B. Hittner, Harshini Mukundan, Prakasha Kempaiah, John M. Ong’echa
Publikováno v: Mediators of Inflammation
Mediators of Inflammation, Vol 2016 (2016)
Bacteremia and malaria coinfection is a common and life-threatening condition in children residing in sub-Saharan Africa. We previously showed that coinfection with Gram negative (G[−]) enteric Bacilli andPlasmodium falciparum(Pf[+]) was associated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1dec87951830ae7000c19fdd5cd13c
https://pubmed.ncbi.nlm.nih.gov/27418744
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5
Reduced interferon (IFN)-α conditioned by IFNA2 (−173) and IFNA8 (−884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality
Autor: James B. Hittner, Tom Were, Evans Raballah, Samuel B. Anyona, John M. Ong’echa, Prakasha Kempaiah, Douaglas J. Perkins, Gregory C. Davenport
Publikováno v: Human Genetics. 131:1375-1391
Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, the role of IFN-α in SMA has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7747caf6f7b5400cee635e41d7f3d910
https://doi.org/10.1007/s00439-012-1175-1
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6
Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria
Autor: John M. Ong’echa, Tom Were, Gregory C. Davenport, James B. Hittner, Douglas J. Perkins
Publikováno v: American Journal of Hematology. 87:652-658
Anemia is the primary hematological manifestation of both Plasmodium falciparum malaria and HIV-1 in pediatric populations in sub-Saharan Africa. We have previously shown that HIV-1 positive and exposed children have greater risk of developing severe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a90804dec8515b30a0549c6045752b
https://doi.org/10.1002/ajh.23200
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7
Functional Promoter Haplotypes of Interleukin-18 Condition Susceptibility to Severe Malarial Anemia and Childhood Mortality
Autor: Stephen N. Konah, Douglas J. Perkins, Prakasha Kempaiah, John M. Vulule, James B. Hittner, Collins Ouma, C. W. Gichuki, Gregory C. Davenport, Samuel B. Anyona, John M. Ong’echa, Tom Were, Evans Raballah
Publikováno v: Infection and Immunity. 79:4923-4932
Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children residing in regions where Plasmodium falciparum transmission is holoendemic. Although largely unexplored in children with SMA, interleukin-18 (IL-18) is important
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aeac38613cb6fdfde68e87467d8f99d
https://doi.org/10.1128/iai.05601-11
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8
Identification of Inflammatory Biomarkers for Pediatric Malarial Anemia Severity Using Novel Statistical Methods
Autor: Douglas J. Perkins, John M. Ong’echa, John M. Vulule, James B. Hittner, Gregory C. Davenport
Publikováno v: Infection and Immunity. 79:4674-4680
Areas where Plasmodium falciparum transmission is holoendemic are characterized by high rates of pediatric severe malarial anemia (SMA) and associated mortality. Although the etiology of SMA is complex and multifactorial, perturbations in inflammator
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1f3c31e09aa165a933434a0d5040ef
https://doi.org/10.1128/iai.05161-11
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9
Severe Malarial Anemia: Innate Immunity and Pathogenesis
Autor: Douglas J. Perkins, Prakasha Kempaiah, Gregory C. Davenport, James B. Hittner, Tom Were, John M. Ong’echa
Publikováno v: International Journal of Biological Sciences
Greater than 80% of malaria-related mortality occurs in sub-Saharan Africa due to infections with Plasmodium falciparum. The majority of P. falciparum-related mortality occurs in immune-naïve infants and young children, accounting for 18% of all dea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011162fd798deb8e977f15b7db43a9cb
https://doi.org/10.7150/ijbs.7.1427
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10
Clinical predictors of severe malarial anaemia in a holoendemic Plasmodium falciparum transmission area
Autor: Douglas J. Perkins, Gregory C. Davenport, James B. Hittner, Stephen Obaro, Sandra S. Kaplan, Enrico M. Novelli, Tom Were, Collins Ouma, John M. Ong’echa
Publikováno v: British Journal of Haematology. 149:711-721
Summary Severe malarial anaemia (SMA) is a common complication of Plasmodium falciparum infections, resulting in mortality rates that may exceed 30% in paediatric populations residing in holoendemic transmission areas. One strategy for reducing the m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0f1aa24b3d23b6caf6a097baa0e14ed
https://doi.org/10.1111/j.1365-2141.2010.08147.x
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