Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Gregory C. Adam"'
Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease
Autor:
Rajini R. Mudhasani, Joseph W. Golden, Gregory C. Adam, Timothy J. Hartingh, Krishna P. Kota, David Ordonez, Corey R. Quackenbush, Julie P. Tran, Curtis Cline, Janice A. Williams, Xiankun Zeng, David B. Olsen, Linda A. Lieberman, Christopher Boyce, Anthony Ginnetti, J. Matthew Meinig, Rekha G. Panchal, Eric M. Mucker
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTAlthough smallpox has been eradicated, other orthopoxviruses continue to be a public health concern as exemplified by the ongoing Mpox (formerly monkeypox) global outbreak. While medical countermeasures (MCMs) previously approved by the Food
Externí odkaz:
https://doaj.org/article/53df8f67d29d4344baea9e9e6311d3a1
Autor:
Nadine Alvarez, Gregory C. Adam, John A. Howe, Vijeta Sharma, Matthew D. Zimmerman, Enriko Dolgov, Risha Rasheed, Fatima Nizar, Khushboo Sahay, Andrew M. Nelson, Steven Park, Xiaoyan Zhou, Christine Burlein, John F. Fay, Daniel V. Iwamoto, Carolyn M. Bahnck-Teets, Krista L. Getty, Shih Lin Goh, Imad Salhab, Keith Smith, Christopher W. Boyce, Tamara D. Cabalu, Nicholas Murgolo, Nicholas G. Fox, Todd W. Mayhood, Valerie W. Shurtleff, Mark E. Layton, Craig A. Parish, John A. McCauley, David B. Olsen, David S. Perlin
Publikováno v:
Viruses, Vol 16, Iss 7, p 1158 (2024)
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) continues to be a global threat due to its ability to evolve and generate new subvariants, leading to new waves of infection. Additionally, other coronaviruses like Middle East respira
Externí odkaz:
https://doaj.org/article/5a441246ad714e97bc953aaa660b6bd5
Autor:
Mali Cosden, Sarah Jinn, Lihang Yao, Cheryl A. Gretzula, Monika Kandebo, Dawn Toolan, Nathan G. Hatcher, Lei Ma, Wei Lemaire, Gregory C. Adam, Christine Burlein, Christina Minnick, Rose Flick, Marla L. Watt, James Mulhearn, Mark Fraley, Robert E. Drolet, Jacob N. Marcus, Sean M. Smith
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105507- (2021)
Mutations in the lysosomal enzyme glucocerebrosidase (GCase, GBA1 gene) are the most common genetic risk factor for developing Parkinson's disease (PD). GCase metabolizes the glycosphingolipids glucosylceramide (GlcCer) and glucosylsphingosine (GlcSp
Externí odkaz:
https://doaj.org/article/5bb119e476704557a1fe920f9ef43979
Autor:
Anthony J. Roecker, Kathy M. Schirripa, H. Marie Loughran, Ling Tong, Tao Liang, Kerry L. Fillgrove, Yuhsin Kuo, Kelly Bleasby, Hannah Collier, Michael D. Altman, Melissa C. Ford, Robert E. Drolet, Mali Cosden, Sarah Jinn, Nathan G. Hatcher, Lihang Yao, Monika Kandebo, Joshua D. Vardigan, Rosemarie B. Flick, Xiaomei Liu, Christina Minnick, Laura A. Price, Marla L. Watt, Wei Lemaire, Christine Burlein, Gregory C. Adam, Lauren A. Austin, Jacob N. Marcus, Sean M. Smith, Mark E. Fraley
Publikováno v:
ACS Medicinal Chemistry Letters. 14:146-155
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a75f2713f77a436a3c71e753c7d659
https://doi.org/10.1021/acsmedchemlett.2c00441
https://doi.org/10.1021/acsmedchemlett.2c00441
Autor:
Cheng Wang, Gregory C. Adam, Christine Burlein, Steven Carroll, William Dankulich, Tracy Diamond, Jay Grobler, Jeffrey Heath, Adam Johnson, Daniel Klein, Daniel Krosky, Kartik Narayan, Yangsi Ou, John Sanders, Sujata Sharma, Min Xu, Antonella Converso
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 89:129303
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d33474aea1f4a8f86196121a032c4c1
https://doi.org/10.1016/j.bmcl.2023.129303
https://doi.org/10.1016/j.bmcl.2023.129303
Autor:
Scott E. Wolkenberg, Richard J. O. Barnard, Steven N. Gallicchio, Michael A. Plotkin, Douglas C. Beshore, Christine Burlein, Robert W. Myers, M. Katharine Holloway, Daniel J. Klein, Vanessa L. Rada, Christopher D. Cox, David A. Powell, Daniel Krosky, Paul J. Coleman, Gregory C. Adam, Sangita B. Patel, Wei Lemaire
Publikováno v:
ACS Medicinal Chemistry Letters
A novel series of histone deacetylase (HDAC) inhibitors lacking a zinc-binding moiety has been developed and described herein. HDAC isozyme profiling and kinetic studies indicate that these inhibitors display a selectivity preference for HDACs 1, 2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d663d85c125a580cc2715339d0489294
http://europepmc.org/articles/PMC8040053
http://europepmc.org/articles/PMC8040053
Autor:
Andreas Verras, Lei Zhang, Aileen Soriano, Gregory O'Donnell, Emily Frank, Andrea D. Basso, David J. Bell, Paul Tawa, W. Michael Seganish, Jennifer Hanisak, Yang Yu, Gregory C. Adam, David R. Bauman
Publikováno v:
ACS Med Chem Lett
[Image: see text] PKG1α is a central node in cGMP signaling. Current therapeutics that look to activate this pathway rely on elevation of cGMP levels and subsequent activation of PKG1α. Direct activation of PKG1α could potentially drive additional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b05d721292d7270027b12125728c49
https://europepmc.org/articles/PMC8365999/
https://europepmc.org/articles/PMC8365999/
Autor:
Ian M. Bell, Steve S. Carroll, Paula J. Hancock, Richard J. O. Barnard, M. Katharine Holloway, David M. Tellers, Alan Hruza, Gregory C. Adam, Christopher D. Cox, Peter S. Kutchukian, Matthew Tudor, Jing Li, B. Wesley Trotter, Anthony W. Shaw, Corey Strickland, Marina Bukhtiyarova, Scott E. Wolkenberg, David A. Powell, Erica M. Cook, Ivan Cornella-Taracido, Philip M. McKenna
Publikováno v:
ACS Med Chem Lett
[Image: see text] By employing a phenotypic screen, a set of compounds, exemplified by 1, were identified which potentiate the ability of histone deacetylase inhibitor vorinostat to reverse HIV latency. Proteome enrichment followed by quantitative ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044ab3f8cda6a53fa6e2f5e0430b729b
https://pubmed.ncbi.nlm.nih.gov/33488970
https://pubmed.ncbi.nlm.nih.gov/33488970
Autor:
Christopher A. Strulson, Xuanwen Li, Rong-Sheng Yang, Divya Chandra, Douglas D. Richardson, An Chi, Jonathan Welch, Smaranda Bodea, Alex Dow, Simon Letarte, Gregory C. Adam
Polysorbate is widely used to maintain stability of biotherapeutic proteins in formulation development. Degradation of polysorbate can lead to particle formation in drug products, which is a major quality concern and potential patient risk factor. En
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ab5b0f5d0ae61add439523cf28edba1
https://doi.org/10.1101/2020.10.07.330076
https://doi.org/10.1101/2020.10.07.330076
Autor:
Marla L. Watt, Sarah Jinn, Nathan G. Hatcher, Lei Ma, Mali Cosden, Monika Kandebo, Christine Burlein, Christina Minnick, Mark E. Fraley, Cheryl A. Gretzula, Wei Lemaire, Rose B. Flick, Sean M. Smith, James Mulhearn, Gregory C. Adam, Jacob Marcus, Robert E. Drolet, Dawn Toolan, Lihang Yao
Publikováno v:
Neurobiology of Disease, Vol 159, Iss, Pp 105507-(2021)
Mutations in the lysosomal enzyme glucocerebrosidase (GCase, GBA1 gene) are the most common genetic risk factor for developing Parkinson's disease (PD). GCase metabolizes the glycosphingolipids glucosylceramide (GlcCer) and glucosylsphingosine (GlcSp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cd5da06600d31f6c7bb67bb7f45f07
https://doi.org/10.1016/j.nbd.2021.105507
https://doi.org/10.1016/j.nbd.2021.105507