Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Gregory C Leo"'
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0198156 (2018)
Roux-en-Y gastric bypass (RYGB) is an effective way to lose weight and reverse type 2 diabetes. We profiled the metabolome of 18 obese patients (nine euglycemic and nine diabetics) that underwent RYGB surgery and seven lean subjects. Plasma samples f
Externí odkaz:
https://doaj.org/article/4ede0c57c7344c15a45d43f607679995
Autor:
Fang Liu-Walsh, John A. Masucci, James E. Hauschild, Gregory C Leo, Kimberly A. Capone, Allison Rush, Neena K. Tierney
Publikováno v:
Clinical, Cosmetic and Investigational Dermatology
Fang Liu-Walsh,1 Neena K Tierney,1 James Hauschild,2 Allison K Rush,1 John Masucci,3 Gregory C Leo,3 Kimberly A Capone1 1Johnson & Johnson Consumer Inc., Skillman, NJ, USA; 2Johnson & Johnson Microbiological Quality & Sterility Assurance, Johnson & J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eca92dd3acb68d27da534ed0b88806d
https://doi.org/10.2147/ccid.s253386
https://doi.org/10.2147/ccid.s253386
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0198156 (2018)
PLoS ONE
PLoS ONE
Roux-en-Y gastric bypass (RYGB) is an effective way to lose weight and reverse type 2 diabetes. We profiled the metabolome of 18 obese patients (nine euglycemic and nine diabetics) that underwent RYGB surgery and seven lean subjects. Plasma samples f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0691984b68029bc71915648773afaf
http://europepmc.org/articles/PMC5979615?pdf=render
http://europepmc.org/articles/PMC5979615?pdf=render
Roux-en-Y gastric bypass (RYGB) is an effective way to lose weight and reverse type 2 diabetes. We profiled the metabolome of 18 obese patients (nine euglycemic and nine diabetics) that underwent RYGB surgery and seven lean subjects. Plasma samples f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff28fc83944d1140946623cd7a503d8
Autor:
Gregory C. Leo, Gary W. Caldwell
Publikováno v:
Current Topics in Medicinal Chemistry. 17
Untargeted metabolomics is a promising approach for reducing the significant attrition rate for discovering and developing drugs in the pharmaceutical industry. This review aims to highlight the practical decision-making value of untargeted metabolom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a7a16631d9ece85cc3c6d546a0c823
https://doi.org/10.2174/1568026617666170707130032
https://doi.org/10.2174/1568026617666170707130032
Autor:
James Lenhard, Gregory C. Leo, Matthew Jennis, Cassandre R. Cavanaugh, Pamela J. Hornby, John R. Mabus
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 30(2)
Background The diet and microbiome contribute to metabolic disease in part due to increased intestinal inflammation and permeability. Dietary tryptophan is metabolized by both mammalian and bacterial enzymes. Using in vitro, in vivo models, and clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53338aa2dfd3decc135cc8ec91464d2
https://pubmed.ncbi.nlm.nih.gov/28782205
https://pubmed.ncbi.nlm.nih.gov/28782205
Autor:
Shawn Branum, Fawzy Nagy E, Christopher A. Teleha, Luc Van Der Steen, Mark J. Wall, Derek A. Beauchamp, Michael Reuman, Marc Verbeek, Michael Kolpak, Zhihua Sui, Chaozhong Cai, Gregory C. Leo, Ronald K. Russell, Yongzheng Zhang, Fu-An Kang, Hilde Vanbaelen
Publikováno v:
Organic Process Research & Development. 18:1622-1629
The preparation of a novel chemokine receptor type 2 (CCR-2) antagonist is described on a 135 g scale. The synthesis of an all-carbon bicyclic core was accomplished using a radical cyclization strategy using chiral precursors, wherein elaboration led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30ed40727f516d73f0e1e4e53e8301d9
https://doi.org/10.1021/op500265z
https://doi.org/10.1021/op500265z
Autor:
Ronald K. Russell, Yongzheng Zhang, Marc Verbeek, Michael Reuman, Zhihua Sui, Hilde Vanbaelen, Christopher A. Teleha, Shawn Branum, James C. Lanter, Fawzy Nagy E, Fu-An Kang, Luc Van Der Steen, Michael Kolpak, Michael P. Winters, Derek A. Beauchamp, Gregory C. Leo
Publikováno v:
Organic Process Research & Development. 18:1630-1640
The preparation of a chemokine receptor type 2 (CCR-2) antagonist bearing a cyclopenta[b]furan core is described on a 600 g scale. Compared to our previously reported synthesis of the all-carbon core CCR-2 antagonist with a similar peripheral 3-metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6e2ea61a6b3e2fe6f4999868e3c1c57
https://doi.org/10.1021/op500266w
https://doi.org/10.1021/op500266w
Autor:
Gregory C. Leo, Andrew L. Darrow
Publikováno v:
Magnetic Resonance in Chemistry. 47:S20-S25
NMR-based metabolomics of mouse urine was used in conjunction with the traditional staining and imaging of aortas for the characterization of disease advancement, that is, plaque formation in untreated and drug-treated apolipoprotein-E (apoE) knockou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a4a1cb703024f32008950d065dfc9ae
https://doi.org/10.1002/mrc.2470
https://doi.org/10.1002/mrc.2470
Publikováno v:
Drug Metabolism and Disposition. 35:21-29
Comparative metabolite profiling of geldanamycin and 17-allylamino-17-demethoxygeldanamycin (17AAG) using human liver microsomes in normoxia and hypoxia was conducted to understand their differential metabolic fates. Geldanamycin bearing a 17-methoxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8788c67421bf7f41104e53a8688e00
https://doi.org/10.1124/dmd.106.009639
https://doi.org/10.1124/dmd.106.009639