Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Gregory C Howard"'
Autor:
Andrew J. Siladi, Jing Wang, Andrea C. Florian, Lance R. Thomas, Joy H. Creighton, Brittany K. Matlock, David K. Flaherty, Shelly L. Lorey, Gregory C. Howard, Stephen W. Fesik, April M. Weissmiller, Qi Liu, William P. Tansey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context in a range of chromatin-centric processes. WDR5 is also a prominent target for pharmacological inhibition in cancer. Small-molecule degraders of WDR5 ha
Externí odkaz:
https://doaj.org/article/4970649d70db445fb70eaa8e823937b6
Autor:
April M. Weissmiller, Jing Wang, Shelly L. Lorey, Gregory C. Howard, Ernest Martinez, Qi Liu, William P. Tansey
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
SMARCB1/SNF5 is a tumour suppressor and component of the SWI/SNF chromatin remodeler. Here the authors show that, independent of chromatin remodelling activities, SNF5 acts to inhibit the pro-tumorigenic transcriptional program of MYC via control of
Externí odkaz:
https://doaj.org/article/13320eef54514e9293ebfcb6fc8bf6ca
Autor:
Erin R. Aho, Jing Wang, Rocco D. Gogliotti, Gregory C. Howard, Jason Phan, Pankaj Acharya, Jonathan D. Macdonald, Ken Cheng, Shelly L. Lorey, Bin Lu, Sabine Wenzel, Audra M. Foshage, Joseph Alvarado, Feng Wang, J. Grace Shaw, Bin Zhao, April M. Weissmiller, Lance R. Thomas, Christopher R. Vakoc, Matthew D. Hall, Scott W. Hiebert, Qi Liu, Shaun R. Stauffer, Stephen W. Fesik, William P. Tansey
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 2916-2928.e13 (2019)
Summary: The chromatin-associated protein WDR5 is a promising target for pharmacological inhibition in cancer. Drug discovery efforts center on the blockade of the “WIN site” of WDR5, a well-defined pocket that is amenable to small molecule inhib
Externí odkaz:
https://doaj.org/article/624392b24e9c465daac627e90b1195e5
Autor:
Kevin B. Teuscher, Somenath Chowdhury, Kenneth M. Meyers, Jianhua Tian, Jiqing Sai, Mayme Van Meveren, Taylor M. South, John L. Sensintaffar, Tyson A. Rietz, Soumita Goswami, Jing Wang, Brian C. Grieb, Shelly L. Lorey, Gregory C. Howard, Qi Liu, William J. Moore, Gordon M. Stott, William P. Tansey, Taekyu Lee, Stephen W. Fesik
Publikováno v:
Proceedings of the National Academy of Sciences. 120
WD repeat domain 5 (WDR5) is a core scaffolding component of many multiprotein complexes that perform a variety of critical chromatin-centric processes in the nucleus. WDR5 is a component of the mixed lineage leukemia MLL/SET complex and localizes MY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55525b23552d424473dfa053dbc6302
https://doi.org/10.1073/pnas.2211297120
https://doi.org/10.1073/pnas.2211297120
Autor:
Stephen W. Fesik, Dai H. Chung, William P. Tansey, David K. Flaherty, Alissa D. Guarnaccia, Eric J. Rellinger, April M. Weissmiller, Shelly L. Lorey, Brittany K. Matlock, Erin R. Aho, Chase M Woodley, Gregory C. Howard, Qi Liu, Audra F Bryan, Jing Wang
Publikováno v:
Nucleic Acids Research
WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule inhibitors of an arginine-binding pocke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e98e8c1595ddbc0d9942a951da6351
https://doi.org/10.1093/nar/gkaa051
https://doi.org/10.1093/nar/gkaa051
Autor:
Andrea C Florian, Chase M Woodley, Jing Wang, Brian C Grieb, Macey J Slota, Kiana Guerrazzi, Chih-Yuan Hsu, Brittany K Matlock, David K Flaherty, Shelly L Lorey, Stephen W Fesik, Gregory C Howard, Qi Liu, April M Weissmiller, William P Tansey
Publikováno v:
NAR Cancer. 4
Rhabdoid tumors (RT) are rare and deadly pediatric cancers driven by loss of SMARCB1, which encodes the SNF5 component of the SWI/SNF chromatin remodeler. Loss of SMARCB1 is associated with a complex set of phenotypic changes including vulnerability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c1ae2baaa33cc7b2716171e0f5d199
https://doi.org/10.1093/narcan/zcac007
https://doi.org/10.1093/narcan/zcac007
Autor:
Andrew J. Siladi, Jing Wang, Andrea C. Florian, Lance R. Thomas, Joy H. Creighton, Brittany K. Matlock, David K. Flaherty, Shelly L. Lorey, Gregory C. Howard, Stephen W. Fesik, April M. Weissmiller, Qi Liu, William P. Tansey
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context in a range of chromatin-centric processes. WDR5 is also a prominent target for pharmacological inhibition in cancer. Small-molecule degraders of WDR5 have been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd72ecac5f8c74991ee8dce4e5b78a0d
https://pubmed.ncbi.nlm.nih.gov/35115608
https://pubmed.ncbi.nlm.nih.gov/35115608
Autor:
Jing Wang, April M. Weissmiller, Stacy D. Sherrod, Tessa M. Popay, Simona G. Codreanu, Qi Liu, Lance R. Thomas, John A. McLean, Clare M. Adams, William P. Tansey, Gregory C. Howard, Christine M. Eischen, Shelly L. Lorey, Yuichi J. Machida
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may come from understanding the co-factors it uses to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934203009b3bc42bf5b991f8353ac55f
https://elifesciences.org/articles/60191
https://elifesciences.org/articles/60191
Autor:
Qi Liu, Stacy D. Sherrod, Simona G. Codreanu, April M. Weissmiller, Shelly L. Lorey, Clare M. Adams, Yuichi J. Machida, John A. McLean, Tessa M. Popay, Jing Wang, Lance R. Thomas, Christine M. Eischen, Gregory C. Howard, William P. Tansey
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b1a4240863cd22f5ecb010e038ad131
https://doi.org/10.7554/elife.60191.sa2
https://doi.org/10.7554/elife.60191.sa2
Autor:
William P. Tansey, Jing Wang, April M. Weissmiller, Qi Liu, Ernest Martinez, Shelly L. Lorey, Gregory C. Howard
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
SMARCB1 encodes the SNF5 subunit of the SWI/SNF chromatin remodeler. SNF5 also interacts with the oncoprotein transcription factor MYC and is proposed to stimulate MYC activity. The concept that SNF5 is a coactivator for MYC, however, is at odds with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b979363e3910849d15a223b1d2cae6
https://escholarship.org/uc/item/2qg4w9bn
https://escholarship.org/uc/item/2qg4w9bn