Výsledky vyhledávání - "Gregory C, Donohoe"

Hydrogen Peroxide Modifies Aβ-Membrane Interactions with Implications for Aβ

Autor: Albert W, Pilkington, Gregory C, Donohoe, Novruz G, Akhmedov, Timothy, Ferrebee, Stephen J, Valentine, Justin, Legleiter

Publikováno v: Biochemistry. 58(26)

Alzheimer's disease (AD) is pathologically characterized by the formation of extracellular senile plaques, predominately comprised of aggregated β-amyloid (Aβ), deposited in the brain. Aβ aggregation can result in a myriad of distinct aggregate sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b2a448c5241cb4805edbe1e20a7f27b
https://pubmed.ncbi.nlm.nih.gov/31187978

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Ion Mobility Spectrometry-Hydrogen Deuterium Exchange Mass Spectrometry of Anions: Part 2. Assessing Charge Site Location and Isotope Scrambling

Autor: Stephen J. Valentine, Samaneh Ghassabi Kondalaji, Gregory C. Donohoe, Mahdiar Khakinejad

Publikováno v: Journal of the American Society for Mass Spectrometry. 27:451-461

Ion mobility spectrometry (IMS) coupled with gas-phase hydrogen deuterium exchange (HDX)-mass spectrometry (MS) and molecular dynamic simulations (MDS) has been used for structural investigation of anions produced by electrospraying a sample containi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48d0c0c357392cc96e2413e5bfa8fd0
https://doi.org/10.1007/s13361-015-1304-x

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Comparative plasma proteomic studies of pulmonary TiO2 nanoparticle exposure in rats using liquid chromatography tandem mass spectrometry

Autor: Jinghai Yi, Megan M. Maurer, Stephen J. Valentine, Timothy R. Nurkiewicz, Gregory C. Donohoe, Hossein Maleki, Carroll R. McBride

Publikováno v: Journal of Proteomics. 130:85-93

Mounting evidence suggests that pulmonary exposure to nanoparticles (NPs) has a toxic effect on biological systems. A number of studies have shown that exposure to NPs result in systemic inflammatory response, oxidative stress, and leukocyte adhesion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43aeb6fb3c2cccf47cf56ba196b30203
https://doi.org/10.1016/j.jprot.2015.09.010

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Ion Mobility Spectrometry-Hydrogen Deuterium Exchange Mass Spectrometry of Anions: Part 3. Estimating Surface Area Exposure by Deuterium Uptake

Autor: Mahdiar Khakinejad, Samaneh Ghassabi Kondalaji, Gregory C. Donohoe, Stephen J. Valentine

Publikováno v: Journal of the American Society for Mass Spectrometry. 27:462-473

Gas-phase hydrogen deuterium exchange (HDX), collision cross section (CCS) measurement, and molecular dynamics simulation (MDS) techniques were utilized to develop and compare three methods for estimating the relative surface area exposure of separat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0596a24809197a045e53f185854e6a5
https://doi.org/10.1007/s13361-015-1305-9

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Online Deuterium Hydrogen Exchange and Protein Digestion Coupled with Ion Mobility Spectrometry and Tandem Mass Spectrometry

Autor: Gregory C. Donohoe, James R. Arndt, Stephen J. Valentine

Publikováno v: Analytical Chemistry. 87:5247-5254

Online deuterium hydrogen exchange (DHX) and pepsin digestion (PD) is demonstrated using drift tube ion mobility spectrometry (DTIMS) coupled with linear ion trap (LTQ) mass spectrometry (MS) with electron transfer dissociation (ETD) capabilities. DH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739bf56898aee219076d3b37e87f2c67
https://doi.org/10.1021/acs.analchem.5b00277

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Ion Mobility Spectrometry-Hydrogen Deuterium Exchange Mass Spectrometry of Anions: Part 1. Peptides to Proteins

Autor: Mahdiar Khakinejad, Gregory C. Donohoe, Stephen J. Valentine

Publikováno v: Journal of the American Society for Mass Spectrometry. 26:564-576

Ion mobility spectrometry (IMS) coupled with hydrogen deuterium exchange (HDX)-mass spectrometry (MS) has been used to study the conformations of negatively-charged peptide and protein ions. Results are presented for ion conformers of angiotensin 1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7438296c5a00214edfd6e75acd195130
https://doi.org/10.1007/s13361-014-1045-2

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Combining Ion Mobility Spectrometry with Hydrogen-Deuterium Exchange and Top-Down MS for Peptide Ion Structure Analysis

Autor: James R. Arndt, Hossein Maleki, Mahdiar Khakinejad, Samaneh Ghassabi Kondalaji, Gregory C. Donohoe, Stephen J. Valentine

Publikováno v: Journal of the American Society for Mass Spectrometry. 25:2103-2115

The gas-phase conformations of electrosprayed ions of the model peptide KKDDDDIIKIIK have been examined by ion mobility spectrometry (IMS) and hydrogen deuterium exchange (HDX)-tandem mass spectrometry (MS/MS) techniques. [M+4H](4+) ions exhibit two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1819eddcca593362142f5eb6b31cf1d
https://doi.org/10.1007/s13361-014-0990-0

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A New Ion Mobility–Linear Ion Trap Instrument for Complex Mixture Analysis

Autor: Hossein Maleki, Carroll R. McBride, James R. Arndt, Mahdiar Khakinejad, Gregory C. Donohoe, Stephen J. Valentine, Jinghai Yi, Timothy R. Nurkiewicz

Publikováno v: Analytical Chemistry. 86:8121-8128

A new instrument that couples a low-pressure drift tube with a linear ion trap mass spectrometer is demonstrated for complex mixture analysis. The combination of the low-pressure separation with the ion trapping capabilities provides several benefits

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1234e3fdfafd861fee1e9e16f051978
https://doi.org/10.1021/ac501527y

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