Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gregory Beuerlein"'
Autor:
James E. Wooldridge, Brian J. Smith, Julie A. Bowles, Allan Barrett W, David Matthew Marquis, Brian K. Link, George J. Weiner, Mary-Ann Campbell, James B. Breitmeyer, Siao-Yi Wang, Brian Ondek, Gregory Beuerlein
Publikováno v:
Blood. 108:2648-2654
Growing evidence indicates that the affinity of monoclonal antibodies (mAbs) for CD16 (FcγRIII) plays a central role in the ability of the mAb to mediate antitumor activity. We evaluated how CD16 polymorphisms, and mAb with modified affinity for tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3750efad5d8bcdd8f618dc3dd2d4b472
https://doi.org/10.1182/blood-2006-04-020057
https://doi.org/10.1182/blood-2006-04-020057
Autor:
Christophe C. Marchal, Irene Denning, Peter Edward Vaillancourt, Timothy R. Holzer, Jessica A. Roseberry Baker, Aaron M Gruver, Mark Wortinger, Jirong Lu, Julian Davies, Jeffrey C. Hanson, Sameera R. Wijayawardana, Ling Liu, Megan E Lacy, Andrew E. Schade, Hadrian P. Szpurka, Sau-Chi B. Yan, Joel D. Cook, Erin M Felke, Wei Zeng, Chi-Kin Chow, Emily Rhoads, Kelly M. Credille, Gregory Beuerlein
Publikováno v:
Histopathology. 65(6)
Development of novel targeted therapies directed against hepatocyte growth factor (HGF) or its receptor (MET) necessitates the availability of quality diagnostics to facilitate their safe and effective use. Limitations of some commercially available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49e23889656e2ea7274884c9a15c640
https://pubmed.ncbi.nlm.nih.gov/25039923
https://pubmed.ncbi.nlm.nih.gov/25039923
Autor:
Heidi Smith, Herren Wu, Ying Nie, Bruce A. Lee, Mary E. Hensler, William D. Huse, Jeffry D. Watkins, Gregory Beuerlein
Publikováno v:
Proceedings of the National Academy of Sciences. 95:6037-6042
A protein engineering strategy based on efficient and focused mutagenesis implemented by codon-based mutagenesis was developed. Vitaxin, a humanized version of the antiangiogenic antibody LM609 directed against a conformational epitope of the αvβ3i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c39f5e19f788cca3b043535e3f8a87e
https://doi.org/10.1073/pnas.95.11.6037
https://doi.org/10.1073/pnas.95.11.6037
Autor:
Paul R. McFadden, Scott M. Glaser, Jeffry D. Watkins, Gerlinde Pecht, Gregory Beuerlein, William D. Huse
Publikováno v:
Analytical Biochemistry. 253:37-45
We have previously utilized an M13 phage expression system and codon-based mutagenesis to increase the avidity of the tumor-specific antibody, BR96, 65-fold (Yelton et al., 1995, J. Immunol. 155, 1994-2004). Mutants with improved affinity were identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24358a6fc1347e5fd6e958d25e567720
https://doi.org/10.1006/abio.1997.2335
https://doi.org/10.1006/abio.1997.2335
Autor:
James D. Pancook, Gerlinde Pecht, Herren Wu, William D. Huse, Ying Tang, Gregory Beuerlein, Jeffry D. Watkins, Ying Nie
Publikováno v:
Hybridoma and hybridomics. 20(5-6)
Human lymphocytes secreting tumor cell-specific IgM antibodies were enriched in vitro following the stimulation of allogeneic human splenocytes from nontumor-bearing donors with cytostatic tumor cells or tumor cell plasma membrane fractions. The anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29497ead21cd6b72f1ccf7e2a7cbaa3
https://pubmed.ncbi.nlm.nih.gov/11839257
https://pubmed.ncbi.nlm.nih.gov/11839257