Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Gregory B. Fralish"'
Publikováno v:
Cell Reports, Vol 4, Iss 4, Pp 625-632 (2013)
The correct asymmetric placement of inner organs is termed situs solitus and is determined early during development. Failure in symmetry breaking results in conditions ranging from randomized organ arrangement to a complete mirror image, often accomp
Externí odkaz:
https://doaj.org/article/cff886e2f38e4af3b07154f01d6938ba
Autor:
Larry S. Barak, Wei Chen, Gregory B. Fralish, Alyson W. MacInnes, Alison R. Meloni, Marc G. Caron, Melanie Philipp
Publikováno v:
Molecular Biology of the Cell. 19:5478-5489
Smoothened, a heptahelical membrane protein, functions as the transducer of Hedgehog signaling. The kinases that modulate Smoothened have been thoroughly analyzed in flies. However, little is known about how phosphorylation affects Smoothened in vert
Publikováno v:
Molecular Endocrinology. 17:1192-1202
Binding of the heterodimeric glycoprotein hormone, chorionic gonadotropin (CG), occurs to the heptahelical LH receptor N-terminal ectodomain (ECD), a large portion of which has been modeled as a leucine-rich repeat protein. In this study, we expresse
Publikováno v:
Plant Physiology. 109:141-152
Polygalacturonate 4-[alpha]-galacturonosyltransferase (EC 2.4.1.43) activity has been identified in microsomal membranes isolated from tobacco (Nicotiana tabacum L. cv Samsun) cell-suspension cultures. Incubation of UDP-[14C]galacturonic acid with to
Autor:
Robert J. Lefkowitz, Robert J. Wechsler-Reya, Ali Salahpour, James K. Chen, Patrick J. Kelly, Marc G. Caron, Gregory B. Fralish, Alison R. Meloni
Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation and differentiation through activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddccc52b81e5cd04edd2741b48f9e50e
https://europepmc.org/articles/PMC1636865/
https://europepmc.org/articles/PMC1636865/
Autor:
Alyson M. Wilbanks, Larry S. Barak, Marc G. Caron, Gregory B. Fralish, Yin-Xiong Li, Margaret L. Kirby
Publikováno v:
Science (New York, N.Y.). 306(5705)
β-arrestins are multifunctional proteins that act as scaffolds and transducers of intracellular signals from heptahelical transmembrane-spanning receptors (7TMR). Hedgehog (Hh) signaling, which uses the putative 7TMR, Smoothened, is established as a
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 17(4)
Human chorionic gonadotropin (hCG) is a placental-derived heterodimeric glycoprotein hormone, which, through the binding and activation of the LH receptor, rescues the corpus luteum and maintains pregnancy. The three-dimensional structure of hCG is k
Publikováno v:
Endocrinology. 142(4)
Reproductive capacity in primates is dependent on the high-affinity binding of the glycoprotein hormones LH and human (h)CG to the large ectodomain (ECD) of their common receptor (LHR). Our understanding of the precise molecular determinants of hormo
Publikováno v:
Molecular and Cellular Biochemistry. 159
Previous studies have demonstrated the presence of super-high affinity endothelin receptors with apparent Kd's on the order of pM in different brain tissues. This study was designed to characterize, in detail, the receptors present in SCP cells, a no
Polygalacturonate 4-α-galacturonosyltransferase (PGA-GalAT) (EC 2.4.1.43), the enzyme that synthesizes the pectin polysaccharide homogalacturonan (HGA), has been identified in microsomal membranes isolated from tobacco (Nicotiana tabacum L. cv Samsu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2fa53c7b388613a9c32e4035055f616
https://doi.org/10.1016/s0921-0423(96)80250-4
https://doi.org/10.1016/s0921-0423(96)80250-4