Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gregory B. Cole"'
Autor:
Riya Shah, Thomas C. Panagiotou, Gregory B. Cole, Trevor F. Moraes, Brigitte D. Lavoie, Christopher A. McCulloch, Andrew Wilde
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cytokinesis is the final step of the cell division cycle that leads to the formation of two new cells. Successful cytokinesis requires significant remodelling of the plasma membrane by spatially distinct β- and γ-actin networks. These netw
Externí odkaz:
https://doaj.org/article/1f9d612d05f84b62a0e2a0218506e856
Autor:
Eve A. Maunders, Matthew W. Giles, Katherine Ganio, Bliss A. Cunningham, Vicki Bennett-Wood, Gregory B. Cole, Dixon Ng, Christine C. Lai, Stephanie L. Neville, Trevor F. Moraes, Christopher A. McDevitt, Aimee Tan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2024)
Klebsiella pneumoniae is a World Health Organization priority pathogen and a significant clinical concern for infections of the respiratory and urinary tracts due to widespread and increasing resistance to antimicrobials. In the absence of a vaccine,
Externí odkaz:
https://doaj.org/article/4a4a93bde406448ca8bda42f7899b3c0
Autor:
Nevraj S Kejiou, Lena Ilan, Stefan Aigner, Enching Luo, Tori Tonn, Hakan Ozadam, Muyoung Lee, Gregory B Cole, Ines Rabano, Nishani Rajakulendran, Brian A Yee, Hamed S Najafabadi, Trevor F Moraes, Stephane Angers, Gene W Yeo, Can Cenik, Alexander F Palazzo
Publikováno v:
Nucleic Acids Research.
In light of the numerous studies identifying post-transcriptional regulators on the surface of the endoplasmic reticulum (ER), we asked whether there are factors that regulate compartment specific mRNA translation in human cells. Using a proteomic su
Publikováno v:
Langmuir. 35:15364-15375
Deposition of calcium phosphate minerals on the elastin-rich medial layers of arteries can cause severe cardiovascular complications. There are no available treatments for medial calcification, and the mechanism of mineral formation on elastin layers
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:1189-1196
Cyclization has been recognized as a valuable technique for increasing the efficacy of small molecule and peptide therapeutics. Here we report the application of a hydrocarbon staple to a rationally-designed cationic antimicrobial peptide (CAP) that
Autor:
Tracy A. Stone, Farheen Khan, Huong Q. Nguyen, Simon Sharpe, Dorna Ravamehr-Lake, Charles M. Deber, Gregory B. Cole
Publikováno v:
Journal of medicinal chemistry. 62(13)
Natural α-helical cationic antimicrobial peptide (CAP) sequences are predominantly amphipathic, with only ca. 2% containing four or more consecutive positively charged amino acids (Lys/Arg). We have designed synthetic CAPs that deviate from these na
Publikováno v:
The Journal of Biological Chemistry
Gram-negative pathogens are enveloped by an outer membrane that serves as a double-edged sword: On the one hand, it provides a layer of protection for the bacterium from environmental insults, including other bacteria and the host immune system. On t
The Vpu protein of HIV-1 functions to downregulate cell surface localization of host proteins involved in the innate immune response to viral infection. For several target proteins, including the NTB-A and PVR receptors and the host restriction facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667603cdad582d61d647d9f1fed51eb6
https://europepmc.org/articles/PMC5685779/
https://europepmc.org/articles/PMC5685779/
Autor:
Simon Sharpe, Gregory B. Cole
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1861:183022
The HIV-1 accessory protein Vpu mediates the downregulation of several host cell proteins, an activity that is critical for viral replication in vivo. As the first step in directing cell-surface proteins to internal cellular compartments, and in many
Autor:
Gregory B. Cole, Simon Sharpe
Publikováno v:
Biophysical Journal. 110(3)
The function of many membrane proteins is dependent on their ability to form higher order homo or hetero oligomers. The host cell restriction factor tetherin, a homo-dimeric transmembrane protein, is responsible for tethering nascent viral particles