Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Gregory A. O'Sullivan"'
Autor:
James M. McCarthy, Selina Wray, Siddharth Sethi, Gregory A. O'Sullivan, Helene Plun-Favreau, Anna Poon, Lee A. Dawson, Harpreet K Saini
Publikováno v:
Stem Cell Reports
Summary Sequestosome-1 (SQSTM1/p62) is involved in cellular processes such as autophagy and metabolic reprogramming. Mutations resulting in the loss of function of SQSTM1 lead to neurodegenerative diseases including frontotemporal dementia. The patho
Autor:
Helen L. Scott, Nicola Buckner, Francesc Fernandez-Albert, Elisa Pedone, Lorena Postiglione, Gongyu Shi, Nicholas Allen, Liang-Fong Wong, Lorenzo Magini, Lucia Marucci, Gregory A. O'Sullivan, Sarah Cole, Justin Powell, Peter Maycox, James B. Uney
Publikováno v:
Journal of Biological Chemistry. 295:5835
Autor:
Marc P. M. Soutar, Liam Kempthorne, Shuichi Miyakawa, Emily Annuario, Daniela Melandri, Jasmine Harley, Gregory A. O’Sullivan, Selina Wray, David C. Hancock, Mark R. Cookson, Julian Downward, Mark Carlton, Hélène Plun-Favreau
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
The discovery of mutations within genes associated with autosomal recessive Parkinson’s disease allowed for the identification of PINK1/Parkin regulated mitophagy as an important pathway for the removal of damaged mitochondria. While recent studies
Autor:
Z-Q Wang, Heinrich Betz, Rolf Bräuer, K R D Al-Saadi, Matthias Ebbinghaus, Gregory A. O'Sullivan, Vijaykumar Yogesh Muley, M Pacyna-Gengelbach, Zhong-Wei Zhou, Iver Petersen, Rainer König, F S Salah
Publikováno v:
Cell Death and Disease
Cell death & disease, 7: e2205
Cell Death & Disease
Cell death & disease, 7: e2205
Cell Death & Disease
GABARAP belongs to an evolutionary highly conserved gene family that has a fundamental role in autophagy. There is ample evidence for a crosstalk between autophagy and apoptosis as well as the immune response. However, the molecular details for these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef8ad4d744dd3cde526d63f9cdc5381
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/42524
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/42524
Publikováno v:
Journal of Comparative Neurology. 520:3962-3981
Inhibitory glycine receptors (GlyRs) are composed of homologous α- (α1-4) and β-subunits. The β-subunits (GlyRβ) interact via their large cytosolic loops with the postsynaptic scaffolding protein gephyrin and are therefore considered essential f
Publikováno v:
Neuroscience Letters. 458:106-110
Gephyrin is a major postsynaptic scaffolding protein at GABAergic and glycinergic inhibitory synapses. Gephyrin-deficient (geph(-/-)) mice die after birth due to disinhibition of motor and sensory pathways resulting from a lack of postsynaptic glycin
Autor:
Heinrich Betz, Orson W. Moe, Gregory A. O'Sullivan, Sonja C. Reining, Serge M. Gisler, Heini Murer, Jürg Biber, Daniel Guido Fuster, Nati Hernando
Publikováno v:
American Journal of Physiology-Renal Physiology. 296:F1118-F1128
Renal reabsorption of inorganic phosphate (Pi) is mainly mediated by the Na+-dependent Pi-cotransporter NaPi-IIa that is expressed in the brush-border membrane (BBM) of renal proximal tubules. Regulation and apical expression of NaPi-IIa are known to
Publikováno v:
Molecular and Cellular Neuroscience. 37:40-55
Amacrine cells are known to express strychnine-sensitive glycine receptors (GlyRs), however, it is not known which of the four GlyRalpha subunits (alpha1-4) are expressed in this diverse group of cells. Herein, we studied the presence of glycine acti
Autor:
Robert J. Harvey, Bodo Laube, Hisahiko Kubota, Kirsten Harvey, Heinrich Betz, Martin Korte, Jörg R. P. Geiger, Marina Retiounskaia, Volker Eulenburg, Swen Hülsmann, Theofilos Papadopoulos, Gregory A. O'Sullivan
Publikováno v:
The EMBO Journal. 26:3888-3899
Collybistin (Cb) is a brain-specific guanine nucleotide exchange factor that has been implicated in plasma membrane targeting of the postsynaptic scaffolding protein gephyrin found at glycinergic and GABAergic synapses. Here we show that Cb-deficient
Autor:
Yannis Kalaidzidis, Stephan W. Schwarzacher, Hong-Xing Chen, Peter Jedlicka, Heba Kalbouneh, Gregory A. O'Sullivan, Jochen Kuhse, Ralph Nawrotzki, Angelo Ippolito, Heinrich Betz, Joachim Kirsch, Thomas Deller
Publikováno v:
Molecular and cellular neurosciences. 72
Mutations that result in the defective trafficking of γ2 subunit containing GABAA receptors (γ2-GABAARs) are known to reduce synaptic inhibition. Whether perturbed clustering of non-mutated GABAARs similarly reduces synaptic inhibition in vivo is l