Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Gregory A. Niemi"'
Autor:
Gregory A. Niemi, Focco van den Akker, Melanie R. Roberts, James B. Hurley, Thomas A. Reh, Visvanathan Ramamurthy
Publikováno v:
Proceedings of the National Academy of Sciences. 100:12630-12635
The most common form of blindness at birth, Leber's congenital amaurosis (LCA), is inherited in an autosomal recessive fashion. Mutations in six different retina-specific genes, including a recently discovered gene, AIPL1 , have been linked to LCA in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705465adbdf7ff82fccf92c87c5240fc
https://doi.org/10.1073/pnas.2134194100
https://doi.org/10.1073/pnas.2134194100
Publikováno v:
Vision Research. 38:1341-1352
Light-stimulated phosphorylation of rhodopsin was first described 25 years ago. This paper reviews the progress that has been made towards (i) understanding the nature of the enzymes that phosphorylate and dephosphorylate rhodopsin (ii) identifying t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12cf53f75d621a3de33ad3bb8b8b635
https://doi.org/10.1016/s0042-6989(97)00459-8
https://doi.org/10.1016/s0042-6989(97)00459-8
Publikováno v:
The Journal of Neuroscience. 17:4236-4242
A red-blind zebrafish mutant,partial optokinetic response b (pob), has been isolated by measuring eye movements of larvae in a three-generation screen for recessive mutations affecting the visual system.poblarvae exhibit eye movements in response to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ecedfeb3342f96af9a6d8fb46a6ed7
https://doi.org/10.1523/jneurosci.17-11-04236.1997
https://doi.org/10.1523/jneurosci.17-11-04236.1997
Autor:
David B. McKay, Sergey Zozulya, Lubert Stryer, Doane Brolley, Alexander M. Dizhoor, James B. Hurley, Kevin M. Flaherty, Gregory A. Niemi, Sanghamitra Ray
Publikováno v:
Proceedings of the National Academy of Sciences. 89:5705-5709
Recoverin, a recently discovered 23-kDa calcium-binding protein, activates retinal rod guanylate cyclase when the calcium level is lowered in the submicromolar range. We report here the cloning and sequencing of a cDNA for recoverin from a bovine ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb3d8be85a396b28388e3be64fdb03c
https://doi.org/10.1073/pnas.89.13.5705
https://doi.org/10.1073/pnas.89.13.5705
Publikováno v:
Neuron. 7:429-438
A G protein beta subunit gene (Gbe) is expressed only in the eyes of adult D. melanogaster. This gene was identified by probing a Drosophila head cDNA expression library with monoclonal antibodies to a previously characterized Drosophila G protein be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68153369ff54683c09c12da210d597b
https://doi.org/10.1016/0896-6273(91)90295-b
https://doi.org/10.1016/0896-6273(91)90295-b
Leber congenital amaurosis (LCA4) has been linked to mutations in the photoreceptor-specific gene Aryl hydrocarbon interacting protein like 1 ( Aipl1 ). To investigate the essential role of AIPL1 in retina, we generated a mouse model of LCA by inacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc4b0a8a9d4ae3f082ccff6d43098cb
https://europepmc.org/articles/PMC518850/
https://europepmc.org/articles/PMC518850/
Autor:
Gregory A. Niemi, Susan E. Brockerhoff, Chandra L. Tucker, Hugh R. Matthews, Fred Rieke, Michael Taylor, Breandán N. Kennedy, Gordon L. Fain, James B. Hurley, Marianne Cilluffo, Irina Ankoudinova, Ming Xiao
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(2)
Transducins couple visual pigments to cGMP hydrolysis, the only recognized phototransduction pathway in vertebrate photoreceptors. Here we describe a zebrafish mutant, no optokinetic response f w21 ( nof ), with a nonsense mutation in the gene encodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633f4b80f0d8eadd9cd394b0f249b3f2
https://pubmed.ncbi.nlm.nih.gov/12533607
https://pubmed.ncbi.nlm.nih.gov/12533607
On stimulation, rhodopsin, the light-sensing protein in the rod cells of the retina, is phosphorylated at several sites on its C terminus as the first step in deactivation. We have developed a mass spectrometry–based method to quantify the kinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85a0752cb52ec4b0786e5849a0721cf
https://europepmc.org/articles/PMC2373533/
https://europepmc.org/articles/PMC2373533/
Publikováno v:
The Journal of biological chemistry. 274(16)
Guanylyl cyclase activating protein (GCAP)-1 regulates photoreceptor membrane guanylyl cyclase, RetGC, in a Ca2+-sensitive manner. It contains four Ca2+-binding motifs, EF-hands, three of which are capable of binding Ca2+. GCAP-1 activates RetGC in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9afa3709be19b8e5d1b9db33e6adaf
https://pubmed.ncbi.nlm.nih.gov/10196159
https://pubmed.ncbi.nlm.nih.gov/10196159
Autor:
James B. Hurley, Denis A. Baylor, Marie E. Burns, Gregory A. Niemi, Jeannie Chen, Maribeth Spencer, Melvin I. Simon, Ching-Kang Chen
Phosphorylation is thought to be an essential first step in the prompt deactivation of photoexcited rhodopsin.In vitro, the phosphorylation can be catalyzed either by rhodopsin kinase (RK) or by protein kinase C (PKC). To investigate the specific rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06743102cd505f05c8292f72be4c340b
https://resolver.caltech.edu/CaltechAUTHORS:CHEpnas99b
https://resolver.caltech.edu/CaltechAUTHORS:CHEpnas99b