Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Gregory A. Horwitz"'
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
A major goal of modern neuroscience is to understand the functions of the varied neuronal types that comprise the mammalian brain. Toward this end, some types of neurons can be targeted and manipulated with enhancer-bearing AAV vectors. These vectors
Externí odkaz:
https://doaj.org/article/9db728e58e9c47bc8aec162793268260
Autor:
Gregory D. Horwitz
Publikováno v:
PLoS Biology, Vol 20, Iss 8 (2022)
Externí odkaz:
https://doaj.org/article/70ee7e6356374a9aaba3a4f82bedf63a
Autor:
Abhishek De, Gregory D Horwitz
Publikováno v:
eLife, Vol 11 (2022)
Color perception relies on comparisons between adjacent lights, but how the brain performs these comparisons is poorly understood. To elucidate the underlying mechanisms, we recorded spiking responses of individual V1 neurons in macaque monkeys to pa
Externí odkaz:
https://doaj.org/article/85b19e0d90b54bd580a3112578c8b9cd
Autor:
Trygve E Bakken, Cindy TJ van Velthoven, Vilas Menon, Rebecca D Hodge, Zizhen Yao, Thuc Nghi Nguyen, Lucas T Graybuck, Gregory D Horwitz, Darren Bertagnolli, Jeff Goldy, Anna Marie Yanny, Emma Garren, Sheana Parry, Tamara Casper, Soraya I Shehata, Eliza R Barkan, Aaron Szafer, Boaz P Levi, Nick Dee, Kimberly A Smith, Susan M Sunkin, Amy Bernard, John Phillips, Michael J Hawrylycz, Christof Koch, Gabe J Murphy, Ed Lein, Hongkui Zeng, Bosiljka Tasic
Publikováno v:
eLife, Vol 10 (2021)
Abundant evidence supports the presence of at least three distinct types of thalamocortical (TC) neurons in the primate dorsal lateral geniculate nucleus (dLGN) of the thalamus, the brain region that conveys visual information from the retina to the
Externí odkaz:
https://doaj.org/article/f603ae63e1374a53a6a3312be848bb59
Autor:
Gregory D. Horwitz
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102536- (2021)
Summary: Contrast sensitivity peaks near 10 Hz for luminance modulations and at lower frequencies for modulations between equiluminant lights. This difference is rooted in retinal filtering, but additional filtering occurs in the cerebral cortex. To
Externí odkaz:
https://doaj.org/article/2668ec3bc15643f784274abfa17f99a0
Autor:
John K. Mich, Lucas T. Graybuck, Erik E. Hess, Joseph T. Mahoney, Yoshiko Kojima, Yi Ding, Saroja Somasundaram, Jeremy A. Miller, Brian E. Kalmbach, Cristina Radaelli, Bryan B. Gore, Natalie Weed, Victoria Omstead, Yemeserach Bishaw, Nadiya V. Shapovalova, Refugio A. Martinez, Olivia Fong, Shenqin Yao, Marty Mortrud, Peter Chong, Luke Loftus, Darren Bertagnolli, Jeff Goldy, Tamara Casper, Nick Dee, Ximena Opitz-Araya, Ali Cetin, Kimberly A. Smith, Ryder P. Gwinn, Charles Cobbs, Andrew L. Ko, Jeffrey G. Ojemann, C. Dirk Keene, Daniel L. Silbergeld, Susan M. Sunkin, Viviana Gradinaru, Gregory D. Horwitz, Hongkui Zeng, Bosiljka Tasic, Ed S. Lein, Jonathan T. Ting, Boaz P. Levi
Publikováno v:
Cell Reports, Vol 34, Iss 13, Pp 108754- (2021)
Summary: Viral genetic tools that target specific brain cell types could transform basic neuroscience and targeted gene therapy. Here, we use comparative open chromatin analysis to identify thousands of human-neocortical-subclass-specific putative en
Externí odkaz:
https://doaj.org/article/f3fbdff3e4964a89bce059657aed05d2
Publikováno v:
eLife, Vol 9 (2020)
Optogenetic techniques for neural inactivation are valuable for linking neural activity to behavior but they have serious limitations in macaques. To achieve powerful and temporally precise neural inactivation, we used an adeno-associated viral (AAV)
Externí odkaz:
https://doaj.org/article/f8eb3c5fc1e64a0f837b6db0157e6714
Autor:
Gregory D Horwitz
Publikováno v:
PLoS Biology, Vol 18, Iss 1, p e3000570 (2020)
Stimuli that modulate neuronal activity are not always detectable, indicating a loss of information between the modulated neurons and perception. To identify where in the macaque visual system information about periodic light modulations is lost, sig
Externí odkaz:
https://doaj.org/article/59d085d1ee6e4dc487faa985f3bc58a6
Autor:
Christopher R Fetsch, Naomi N Odean, Danique Jeurissen, Yasmine El-Shamayleh, Gregory D Horwitz, Michael N Shadlen
Publikováno v:
eLife, Vol 7 (2018)
Insights from causal manipulations of brain activity depend on targeting the spatial and temporal scales most relevant for behavior. Using a sensitive perceptual decision task in monkeys, we examined the effects of rapid, reversible inactivation on a
Externí odkaz:
https://doaj.org/article/79b40c4520464636a2e7ee2d0ccab5cb
Autor:
Aaron P, Batista, Gregory D, Horwitz
Publikováno v:
Curr Biol
The study of perceptual decision making in monkeys has provided insights into the process by which sensory evidence is integrated towards a decision. When monkeys make decisions with the knowledge of the motor actions the decisions bear upon, the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8383dd0e1537a512fba74338c422ca
https://doi.org/10.1016/j.cub.2022.03.061
https://doi.org/10.1016/j.cub.2022.03.061