Výsledky vyhledávání - "Gregory A Zornetzer"

Akademický článek

Francisella tularensis subsp. tularensis induces a unique pulmonary inflammatory response: role of bacterial gene expression in temporal regulation of host defense responses.

Autor: Kathie-Anne Walters, Rachael Olsufka, Rolf E Kuestner, Ji Hoon Cho, Hong Li, Gregory A Zornetzer, Kai Wang, Shawn J Skerrett, Adrian Ozinsky

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e62412 (2013)

Pulmonary exposure to Francisella tularensis is associated with severe lung pathology and a high mortality rate. The lack of induction of classical inflammatory mediators, including IL1-β and TNF-α, during early infection has led to the suggestion

Externí odkaz: https://doaj.org/article/10a7b448b18645ae8933f90e24e957df

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The Mitochondrial Targeting Chaperone 14-3-3ε Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity

Autor: Michael G. Katze, Michael Gale, Yueh Ming Loo, Stacy M. Horner, Helene Minyi Liu, Gregory A. Zornetzer

Publikováno v: Cell Host & Microbe. 11(5):528-537

SummaryRIG-I is a cytosolic pathogen recognition receptor that initiates immune responses against RNA viruses. Upon viral RNA recognition, antiviral signaling requires RIG-I redistribution from the cytosol to membranes where it binds the adaptor prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e0bb82d9e684668a0334bc054beed2

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The Length of the Bound Fatty Acid Influences the Dynamics of the Acyl Carrier Protein and the Stability of the Thioester Bond†

Autor: Justinn Tanem, John L. Markley, Gregory A. Zornetzer, Brian G. Fox

Publikováno v: Biochemistry

Acyl carrier proteins involved in fatty acid biosynthesis have been shown to exhibit a high degree of conformational flexibility, in that they are able to sequester fatty acid intermediates between 4 and 18 carbons in length. This flexibility has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c443682515fae7c884393d7926a9873f
http://europepmc.org/articles/PMC2808145

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Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Infection

Autor: Matthew B. Frieman, Matthew D. Dyer, Ralph S. Baric, Gregory A. Zornetzer, Thomas H. Teal, Judith M. A. van den Brand, Bart L. Haagmans, Michael G. Katze, Sean Proll, Tracey Baas, Timothy P. Sheahan, Barry Rockx

Publikováno v: Journal of Virology
Journal of Virology, 83(14), 7062-7074. American Society for Microbiology
Journal of Virology, 83(17), 9022-9022. American Society for Microbiology
Europe PubMed Central

Several respiratory viruses, including influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV), produce more severe disease in the elderly, yet the molecular mechanisms governing age-related susceptibility remain poorly studied.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab83b614e83c0d564c12ae12a3d52319
https://doi.org/10.1128/jvi.00127-09

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Preparation of isotopically labeled spinach acyl–acyl carrier protein for NMR structural studies

Autor: Brian G. Fox, John L. Markley, Robert D. White, Gregory A. Zornetzer

Publikováno v: Protein Expression and Purification. 46:446-455

Acyl carrier proteins (ACPs) are important protein cofactors in fatty acid biosynthesis, but their acylated forms have not been well-studied. To permit detailed nuclear magnetic resonance studies of acylated spinach ACP isoform I, we have developed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15b327556fb949688c5b36f4e4832f4
https://doi.org/10.1016/j.pep.2005.10.015

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Transcriptomic Analysis Reveals a Mechanism for a Prefibrotic Phenotype in STAT1 Knockout Mice during Severe Acute Respiratory Syndrome Coronavirus Infection

Autor: Michael G. Katze, Gregory A. Zornetzer, Matthew B. Frieman, Carly Page, Ralph S. Baric, Elizabeth Rosenzweig, Marcus J. Korth

Publikováno v: Journal of Virology

Severe acute respiratory syndrome coronavirus (SARS-CoV) infection can cause the development of severe end-stage lung disease characterized by acute respiratory distress syndrome (ARDS) and pulmonary fibrosis. The mechanisms by which pulmonary lesion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6994279059cbcab326a9a7cfd02b2b78

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Solution Structures of Spinach Acyl Carrier Protein with Decanoate and Stearate†

Autor: Gregory A. Zornetzer, John L. Markley, Brian G. Fox

Acyl carrier protein (ACP) is a cofactor in a variety of biosynthetic pathways, including fatty acid metabolism. Thus, it is of interest to determine structures of physiologically relevant ACP-fatty acid complexes. We report here the NMR solution str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72343286675a944305fd1c7656acd551
https://europepmc.org/articles/PMC2533275/

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