Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gregory A Breuer"'
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28296 (2011)
Evidence suggests that adenosine acts via cardiac A1 adenosine receptors (A1ARs) to protect embryos against hypoxia. During embryogenesis, A1ARs are the dominant regulator of heart rate, and A1AR activation reduces heart rate. Adenosine action is inh
Externí odkaz:
https://doaj.org/article/489842cc7c424f51a5758fd912335c2f
Autor:
Nathan R. Fons, Ranjini K. Sundaram, Gregory A. Breuer, Sen Peng, Ryan L. McLean, Aravind N. Kalathil, Mark S. Schmidt, Diana M. Carvalho, Alan Mackay, Chris Jones, Ángel M. Carcaboso, Javad Nazarian, Michael E. Berens, Charles Brenner, Ranjit S. Bindra
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase ge
Externí odkaz:
https://doaj.org/article/cc9d2729a55c414fbabbdf50c1cccd2e
Autor:
Gregory A. Breuer, Wanjuan Feng, Nathan R. Fons, Gaorav P. Gupta, Ranjini K. Sundaram, Jonathan Bezney, Ranjit S. Bindra
DNA repair deficiencies have become an increasingly promising target for novel therapeutics within the realm of clinical oncology. Recently, several inhibitors of Poly(ADP-ribose) Polymerases (PARPs) have received approval for the treatment of cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b01e9fb649b8a95b4edc8b58e43c337
https://doi.org/10.1101/2020.10.18.333070
https://doi.org/10.1101/2020.10.18.333070
Autor:
Sreerupa Ray, Joann B. Sweasy, Michelle DeVeaux, Daniel Zelterman, Gregory A. Breuer, Ranjit S. Bindra
Publikováno v:
Nucleic Acids Research
DNA double strand breaks (DSBs) are one of the most deleterious lesions and if left unrepaired, they lead to cell death, genomic instability and carcinogenesis. Cells combat DSBs by two pathways: homologous recombination (HR) and non-homologous end-j
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263d9d32b840e1cdd5e460b4ad5e765a
https://doi.org/10.1093/nar/gkx1147
https://doi.org/10.1093/nar/gkx1147
Autor:
Lee Ying, Geoffrey S. Nadzam, Kathleen A. Martin, Gregory A. Breuer, John Hwa, Matthew O Hubbard
BACKGROUND: Sleeve gastrectomy with ileal transposition has been shown to be superior to sleeve gastrectomy alone for promoting weight loss in rat and porcine models. The absence of a mouse model for this procedure has impeded efforts to understand t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28374093246c8e9b32c5e3ecdd0ecfcd
https://europepmc.org/articles/PMC6365182/
https://europepmc.org/articles/PMC6365182/
Autor:
Ryan A. Hannon, Nicholas Carriero, Ahmed F. Salem, Ruoxi Yu, Ranjini K. Sundaram, Guilin Wang, Gregory A. Breuer, Savina D. Kim, Ranjit S. Bindra, Chen-Pang Soong, Robert D. Bjornson
Publikováno v:
DNA Repair. 26:44-53
Efficient DNA double-strand break (DSB) repair is a critical determinant of cell survival in response to DNA damaging agents, and it plays a key role in the maintenance of genomic integrity. Homologous recombination (HR) and non-homologous end-joinin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29827d63fda4dc24cad73510eb17ed56
https://doi.org/10.1016/j.dnarep.2014.12.002
https://doi.org/10.1016/j.dnarep.2014.12.002
Autor:
Henk M. De Feyter, Nathaniel D. Robinson, Parker L. Sulkowski, Murat Gunel, Gregory A. Breuer, Denise C. Hegan, Susan E. Scanlon, Ketu Mishra-Gorur, Ranjit S. Bindra, Karin Purshouse, Peter M. Glazer, Nathan R. Fons, Yanfeng Liu, Ranjini K. Sundaram, Hanwen Bai, Christopher D. Corso, Stephanie Halene, Maureen Kachman, Robin A. de Graaf, Yulia V. Surovtseva, Yuanbin Song
Publikováno v:
Science translational medicine. 9(375)
2-Hydroxyglutarate (2HG) exists as two enantiomers, (R)-2HG and (S)-2HG, and both are implicated in tumor progression via their inhibitory effects on α-ketoglutarate (αKG)-dependent dioxygenases. The former is an oncometabolite that is induced by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129e421a49698f48360c1f06ba8e8f38
https://pubmed.ncbi.nlm.nih.gov/28148839
https://pubmed.ncbi.nlm.nih.gov/28148839
Autor:
Gregory A. Breuer, Bas van Steensel, Jeannine R. LaRocque, Annelot I. van der Meulen, Aniek Janssen, Sean V. Borden, Ranjit S. Bindra, Gary H. Karpen, Eva K. Brinkman
Publikováno v:
Genesdevelopment. 30(14)
Repair of DNA double-strand breaks (DSBs) must be properly orchestrated in diverse chromatin regions to maintain genome stability. The choice between two main DSB repair pathways, nonhomologous end-joining (NHEJ) and homologous recombination (HR), is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2a55685211f8a12d583b7a354cd737
https://pubmed.ncbi.nlm.nih.gov/27474442
https://pubmed.ncbi.nlm.nih.gov/27474442
Autor:
Nathan R. Fons, Nathaniel D. Robinson, Yilun Liu, Susan E. Scanlon, H.M. De Feyter, Stephanie Halene, Christopher D. Corso, Hanwen Bai, Murat Gunel, Denise C. Hegan, Ketu Mishra-Gorur, Gregory A. Breuer, Yulia V. Surovtseva, Karin Purshouse, R.A. de Graaf, Ranjini K. Sundaram, Yuanbin Song, Maureen Kachman, Ranjit S. Bindra, Parker L. Sulkowski, Peter M. Glazer
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 99:E68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::980a05978c5227193d17b0b8f02f2ca4
https://doi.org/10.1016/j.ijrobp.2017.06.754
https://doi.org/10.1016/j.ijrobp.2017.06.754
Autor:
Gregory A. Breuer, Joann B. Sweasy, Ranjit S. Bindra, Daniel Zelterman, Michelle DeVeaux, Sreerupa Ray
Publikováno v:
Cancer Research. 77:2492-2492
DNA double strand breaks (DSBs) are one of the most deleterious lesions. If left unrepaired, DSBs lead to genomic instability and carcinogenesis. The cells combat DSBs by two classical pathways that include homologous recombination (HR) which require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eec91deb6f474d4b23b669ae39a08760
https://doi.org/10.1158/1538-7445.am2017-2492
https://doi.org/10.1158/1538-7445.am2017-2492