Výsledky vyhledávání - "Gregory, Dyson"

Akademický článek

The Hippo kinases control inflammatory Hippo signaling and restrict bacterial infection in phagocytes

Autor: Brendyn M. St. Louis, Sydney M. Quagliato, Yu-Ting Su, Gregory Dyson, Pei-Chung Lee

Publikováno v: mBio, Vol 15, Iss 5 (2024)

ABSTRACTThe Hippo kinases MST1 and MST2 initiate a highly conserved signaling cascade called the Hippo pathway that limits organ size and tumor formation in animals. Intriguingly, pathogens hijack this host pathway during infection, but the role of M

Externí odkaz: https://doaj.org/article/786cde410d854c51b2f93f71861a2d9b

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Akademický článek

Molecular analysis of XPO1 inhibitor and gemcitabine–nab‐paclitaxel combination in KPC pancreatic cancer mouse model

Autor: Md. Hafiz Uddin, Mohammad Najeeb Al‐Hallak, Husain Yar Khan, Amro Aboukameel, Yiwei Li, Sahar F. Bannoura, Gregory Dyson, Seongho Kim, Yosef Mzannar, Ibrahim Azar, Tanya Odisho, Amr Mohamed, Yosef Landesman, Steve Kim, Rafic Beydoun, Ramzi M. Mohammad, Philip A. Philip, Anthony F. Shields, Asfar S. Azmi

Publikováno v: Clinical and Translational Medicine, Vol 13, Iss 12, Pp n/a-n/a (2023)

Abstract Background The majority of pancreatic ductal adenocarcinoma (PDAC) patients experience disease progression while on treatment with gemcitabine and nanoparticle albumin‐bound (nab)‐paclitaxel (GemPac) necessitating the need for a more eff

Externí odkaz: https://doaj.org/article/746a7f24c49c48c5878e393d3f6d9f55

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Akademický článek

A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors

Autor: Justin B. Hackett, James E. Glassbrook, Maria C. Muñiz, Madeline Bross, Abigail Fielder, Gregory Dyson, Nasrin Movahhedin, Jennifer McCasland, Claire McCarthy-Leo, Heather M. Gibson

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies; however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved in therapy resistance, it is unclear to what extent host genetic bac

Externí odkaz: https://doaj.org/article/c305df24d9bf42e991b7eaf907259bb5

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Akademický článek

The Potential and Limitations of Precision Oncology: Lessons Learned from Whole-Exome Sequencing in an Exceptional Response to Everolimus in Advanced Renal Cell Carcinoma

Autor: Amanda Pilling, Christopher Wee, Eliezer Bar-Meir, Gregory Dyson, Ok Hwang, Nilesh Gupta, Dhananjay Chitale, Clara Hwang

Publikováno v: Case Reports in Oncology, Vol 14, Iss 2, Pp 1194-1200 (2021)

Through elucidating the genetic mechanisms of drug sensitivity, precision medicine aims to improve patient selection and response to therapy. Exceptional responders are patients that exhibit exquisite and durable responses to targeted therapy, provid

Externí odkaz: https://doaj.org/article/76027a3d81af444f87eb9583bc44d535

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Akademický článek

CLCA2 expression is associated with survival among African American women with triple negative breast cancer.

Autor: Kristen S Purrington, Jimmie Knight, Gregory Dyson, Rouba Ali-Fehmi, Ann G Schwartz, Julie L Boerner, Sudeshna Bandyopadhyay

Publikováno v: PLoS ONE, Vol 15, Iss 4, p e0231712 (2020)

PURPOSE:Black/African American (AA) women are twice as likely to be diagnosed with triple negative breast cancer (TNBC) compared to whites, an aggressive breast cancer subtype associated with poor prognosis. There are no routinely used targeted clini

Externí odkaz: https://doaj.org/article/de6eeeb29808483ea7dbcf5ec3d7c100

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Akademický článek

Clinical and immune responses to anti-CD3 x anti-EGFR bispecific antibody armed activated T cells (EGFR BATs) in pancreatic cancer patients

Autor: Lawrence G. Lum, Archana Thakur, Minsig Choi, Abhinav Deol, Vidya Kondadasula, Dana Schalk, Kristie Fields, Melissa Dufrense, Philip Philip, Gregory Dyson, Hussein D. Aon, Anthony F. Shields

Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)

Purpose This was a phase I/II adoptive T cell trial in 7 locally advanced and metastatic pancreatic cancer patients using 3–8 infusions of anti-CD3 x anti-EGFR bispecific antibody armed activated T cells (BATs) to determine safety, the maximum tole

Externí odkaz: https://doaj.org/article/37883bb3779b4c5ca386040a5d50fb03

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