Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens

Autor: Nicholas D. Walter, Sarah E. M. Born, Gregory T. Robertson, Matthew Reichlen, Christian Dide-Agossou, Victoria A. Ektnitphong, Karen Rossmassler, Michelle E. Ramey, Allison A. Bauman, Victor Ozols, Shelby C. Bearrows, Gary Schoolnik, Gregory Dolganov, Benjamin Garcia, Emmanuel Musisi, William Worodria, Laurence Huang, J. Lucian Davis, Nhung V. Nguyen, Hung V. Nguyen, Anh T. V. Nguyen, Ha Phan, Carol Wilusz, Brendan K. Podell, N’ Dira Sanoussi, Bouke C. de Jong, Corinne S. Merle, Dissou Affolabi, Helen McIlleron, Maria Garcia-Cremades, Ekaterina Maidji, Franceen Eshun-Wilson, Brandon Aguilar-Rodriguez, Dhuvarakesh Karthikeyan, Khisimuzi Mdluli, Cathy Bansbach, Anne J. Lenaerts, Radojka M. Savic, Payam Nahid, Joshua J. Vásquez, Martin I. Voskuil

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

It is unclear why different antibiotics vary in their ability to shorten treatment of tuberculosis. Here, the authors show that a measure based on ribosomal RNA synthesis in Mycobacterium tuberculosis correlates with treatment shortening in culture,

Externí odkaz: https://doaj.org/article/e0c6c2c659ca434dbad834a1759cfbb7

Impact of the Mycobaterium africanum West Africa 2 Lineage on TB Diagnostics in West Africa: Decreased Sensitivity of Rapid Identification Tests in The Gambia.

Autor: Boatema Ofori-Anyinam, Fatoumatta Kanuteh, Schadrac C Agbla, Ifedayo Adetifa, Catherine Okoi, Gregory Dolganov, Gary Schoolnik, Ousman Secka, Martin Antonio, Bouke C de Jong, Florian Gehre

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004801 (2016)

BACKGROUND:MPT64 rapid speciation tests are increasingly being used in diagnosis of tuberculosis (TB). Mycobacterium africanum West Africa 2 (Maf 2) remains an important cause of TB in West Africa and causes one third of disease in The Gambia. Since

Externí odkaz: https://doaj.org/article/f825aeaaca17406a9cc82aa539c15232

ESAT-6 (EsxA) and TB10.4 (EsxH) based vaccines for pre- and post-exposure tuberculosis vaccination.

Autor: Truc Hoang, Claus Aagaard, Jes Dietrich, Joseph P Cassidy, Gregory Dolganov, Gary K Schoolnik, Carina Vingsbo Lundberg, Else Marie Agger, Peter Andersen

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e80579 (2013)

The ESX systems from Mycobacterium tuberculosis are responsible for the secretion of highly immunogenic proteins of key importance for bacterial survival and growth. The two prototypic proteins, ESAT-6 (EsxA from ESX-1) and TB10.4 (EsxH from ESX-3) s

Externí odkaz: https://doaj.org/article/91ae68379d044710b9fe964356157327

Four-gene pan-African blood signature predicts progression to tuberculosis

Autor: Sara Suliman, Ethan G. Thompson, Jayne Sutherland, January Weiner, Martin O. C. Ota, Smitha Shankar, Adam Penn-Nicholson, Bonnie Thiel, Mzwandile Erasmus, Jeroen Maertzdorf, Fergal J. Duffy, Philip C. Hill, E. Jane Hughes, Kim Stanley, Katrina Downing, Michelle L. Fisher, Joe Valvo, Shreemanta K. Parida, Gian van der Spuy, Gerard Tromp, Ifedayo M. O. Adetifa, Simon Donkor, Rawleigh Howe, Harriet Mayanja-Kizza, W. Henry Boom, Hazel M. Dockrell, Tom H. M. Ottenhoff, Mark Hatherill, Alan Aderem, Willem A. Hanekom, Thomas J. Scriba, Stefan H. E. Kaufmann, Daniel E. Zak, Gerhard Walzl, Gillian F. Black, Magdalena Kriel, Nelita Du Plessis, Nonhlanhla Nene, Teri Roberts, Leanie Kleynhans, Andrea Gutschmidt, Bronwyn Smith, Andre G. Loxton, Novel N. Chegou, Gerhardus Tromp, David Tabb, Michel R. Klein, Marielle C. Haks, Kees L. M. C. Franken, Annemieke Geluk, Krista E. van Meijgaarden, Simone A. Joosten, Moses Joloba, Sarah Zalwango, Mary Nsereko, Brenda Okwera, Hussein Kisingo, Robert Golinski, Marc Jacobson, Hazel Dockrell, Steven Smith, Patricia Gorak-Stolinska, Yun-Gyoung Hur, Maeve Lalor, Ji-Sook Lee, Amelia C. Crampin, Neil French, Bagrey Ngwira, Anne Ben-Smith, Kate Watkins, Lyn Ambrose, Felanji Simukonda, Hazzie Mvula, Femia Chilongo, Jacky Saul, Keith Branson, Hassan Mahomed, Nicole Bilek, Onke Xasa, Ashley Veldsman, Michelle Fisher, Humphrey Mulenga, Brian Abel, Mark Bowmaker, Benjamin Kagina, William Kwong Chung, Jerry Sadoff, Donata Sizemore, S. Ramachandran, Lew Barker, Michael Brennan, Frank Weichold, Stefanie Muller, Larry Geiter, Desta Kassa, Almaz Abebe, Tsehayenesh Mesele, Belete Tegbaru, Debbie van Baarle, Frank Miedema, Adane Mihret, Abraham Aseffa, Yonas Bekele, Rachel Iwnetu, Mesfin Tafesse, Lawrence Yamuah, Martin Ota, Philip Hill, Richard Adegbola, Tumani Corrah, Martin Antonio, Toyin Togun, Ifedayo Adetifa, Peter Andersen, Ida Rosenkrands, Mark Doherty, Karin Weldingh, Gary Schoolnik, Gregory Dolganov, Tran Van, Fazlin Kafaar, Leslie Workman, Yolundi Cloete, Deborah Abrahams, Sizulu Moyo, Sebastian Gelderbloem, Michele Tameris, Hennie Geldenhuys, Willem Hanekom, Gregory Hussey, Rodney Ehrlich, Suzanne Verver

Publikováno v: American journal of respiratory and critical care medicine, 197(9), 1198-1208. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 197(9), 1198. American Thoracic Society
American journal of respiratory and critical care medicine, vol 197, iss 9
American Journal of Respiratory and Critical Care Medicine, 197(9), 1198-1208

Rationale: Contacts of patients with tuberculosis (TB) constitute an important target population for preventive measures because they are at high risk of infection with Mycobacterium tuberculosis and progression to disease. Objectives: We investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918b39963924be0a306581252709d36a
https://pure.amc.nl/en/publications/fourgene-panafrican-blood-signature-predicts-progression-to-tuberculosis(040a7060-f30a-4cfa-a0f3-e5fd8d66f323).html

Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure

Autor: Stephanus T, Malherbe, Shubhada, Shenai, Katharina, Ronacher, Andre G, Loxton, Gregory, Dolganov, Magdalena, Kriel, Tran, Van, Ray Y, Chen, James, Warwick, Laura E, Via, Taeksun, Song, Myungsun, Lee, Gary, Schoolnik, Gerard, Tromp, David, Alland, Clifton E, Barry, Jill, Winter, Gerhard, Walzl

Publikováno v: Nature medicine

The absence of a gold standard to determine when antibiotics have induced sterilizing cure confounds the development of new approaches to treat pulmonary tuberculosis (PTB). We detected PET-CT imaging response patterns consistent with active disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0aa357493ec9064264620727f8cdc8
https://pubmed.ncbi.nlm.nih.gov/27595324