Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Gregory, Crosby"'
Autor:
Rachel L. Oren, Erin J. Kim, Anna K. Leonard, Bernard Rosner, Lori B. Chibnik, Sudeshna Das, Francine Grodstein, Gregory Crosby, Deborah J. Culley
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Delirium is an acute confusional state and a common postoperative morbidity. Prevalent in older adults, delirium occurs at other ages but it is unclear whether the pathophysiology and biomarkers for the condition are independent of age. We q
Externí odkaz:
https://doaj.org/article/d5208551d75841679c64cbc8fa15fd10
Autor:
Matthew B. Friese, Taranjit S. Gujral, Arvind Palanisamy, Brittany Hemmer, Deborah J. Culley, Gregory Crosby
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionThe development and maintenance of neural circuits is highly sensitive to neural activity. General anesthetics have profound effects on neural activity and, as such, there is concern that these agents may alter cellular integrity and inte
Externí odkaz:
https://doaj.org/article/1ec1488a3491450195bd534c1525c94b
Publikováno v:
Behavioral and Brain Functions, Vol 13, Iss 1, Pp 1-5 (2017)
Abstract Background Our previous research showed that 4 h of maternal anesthesia with isoflurane during early gestation in pregnant rats leads to a deficit in spatial memory of adult male offspring. Because spatial memory is predominantly a hippocamp
Externí odkaz:
https://doaj.org/article/5b5e7fc977ac441a8aaaa791c12ced31
Autor:
Ce, Zhang, Yuan, Han, Xiaojun, Liu, Hong, Tan, Yuanlin, Dong, Yiying, Zhang, Feng, Liang, Hui, Zheng, Gregory, Crosby, Deborah J, Culley, Edward R, Marcantonio, Yuan, Shen, Jun-Li, Cao, Zhongcong, Xie
Publikováno v:
Annals of Surgery. 277:e1387-e1396
Determine the association between olfactory function and cognition in patients and rodents.Perioperative neurocognitive disorders include delayed neurocognitive recovery (dNCR). The contribution of olfactory function to dNCR remains undetermined. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fbaa6379aa64c29568a91f5875ebe4
https://doi.org/10.1097/sla.0000000000005599
https://doi.org/10.1097/sla.0000000000005599
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209283 (2018)
Cognitive dysfunction is one of the most common postoperative complications experienced by older patients after anesthesia and surgery but the cause remains unknown. Immune molecules are essential for many aspects of neural homeostasis, including lea
Externí odkaz:
https://doaj.org/article/e544dbeb595f492aa54e6f360a416856
Autor:
Arvind Palanisamy, Ramaswamy Kannappan, Zhiqiang Xu, Audrey Martino, Matthew B Friese, Justin D Boyd, Gregory Crosby, Deborah J Culley
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191160 (2018)
Synthetic oxytocin (sOT) is widely used during labor, yet little is known about its effects on fetal brain development despite evidence that it reaches the fetal circulation. Here, we tested the hypothesis that sOT would affect early neurodevelopment
Externí odkaz:
https://doaj.org/article/a1e7df645be54081ba9554312d497d4a
Autor:
Arvind Palanisamy, Matthew B Friese, Emily Cotran, Ludde Moller, Justin D Boyd, Gregory Crosby, Deborah J Culley
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158058 (2016)
Neurocognitive dysfunction is common in survivors of intensive care. Prolonged sedation has been implicated but the mechanisms are unclear. Neurogenesis continues into adulthood and is implicated in learning. The neural progenitor cells (NPC) that dr
Externí odkaz:
https://doaj.org/article/b3990d6bfd3a462196e8a00d9cadffa5
Autor:
Timothy R. Smith, Maria J Susano, Angela M. Bader, Bernard Rosner, John H. Chi, Yi Lu, Francine Grodstein, James D. Kang, Gregory Crosby, Rachel H Grasfield, Deborah J. Culley, Michael W. Groff, Matthew B. Friese
Publikováno v:
Anesthesiology. 133:1184-1191
Background Frailty and cognitive impairment are associated with postoperative delirium, but are rarely assessed preoperatively. The study was designed to test the hypothesis that preoperative screening for frailty or cognitive impairment identifies p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6531d1614bc7ab4045112063e78bdb8b
https://doi.org/10.1097/aln.0000000000003523
https://doi.org/10.1097/aln.0000000000003523
Autor:
Deborah J. Culley, Yuan Shen, Edward R. Marcantonio, Ning Liufu, Zhongcong Xie, Shiqian Shen, Minghui Cao, Gregory Crosby, Ling Liu, Zengliang Jiang, Yiying Zhang, Yanyan Wang, Yuanlin Dong
Publikováno v:
Aging (Albany NY)
The neuropathogenesis of postoperative delirium remains mostly unknown. The gut microbiota is implicated in the pathogenesis of neurological disorders. We, therefore, set out to determine whether anesthesia/surgery causes age-dependent gut microbiota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c269f9e0ea795f263fac828a61d9707
https://doi.org/10.18632/aging.102736
https://doi.org/10.18632/aging.102736
Autor:
Yi Lu, Gregory Crosby, James Kang, Timothy R. Smith, Xinling Xu, Dominique Cheung, Rachel H Grasfield, John H. Chi, Maria J Susano, Michael W. Groff, Deborah J. Culley, Seth D. Scheetz
Publikováno v:
J Neurosurg Anesthesiol
BACKGROUND: The aim of this retrospective study was to identify perioperative variables predictive of the development of delirium in older surgical patients after spine surgery. METHODS: We collected pre-, intra- and postoperative data on patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b2967dac20a0eaa0ea384804dbfdc6
https://doi.org/10.1097/ana.0000000000000566
https://doi.org/10.1097/ana.0000000000000566