Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Gregory, Ciszewski"'
Autor:
Dennis Hyek, Jinshan Chen, R. Scott Obach, Melissa Wagenaar, Mark W. Bundesmann, Asser Bassyouni, Jeremy T. Starr, Maria S. Brown, Stephen Jenkinson, Manjinder S. Lall, Gregory Ciszewski, James Bradow, Gregory S. Walker, Senliang Pan, Douglas K. Spracklin, Bo Liu, Neal W. Sach, Daniel J Smaltz, Anne E. Hagen, Usa Reilly
Publikováno v:
Journal of Medicinal Chemistry. 63:7268-7292
An experimental approach is described for late-stage lead diversification of frontrunner drug candidates using nanomole-scale amounts of lead compounds for structure-activity relationship development. The process utilizes C-H bond activation methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a4f2cd830cd5ca3994e400969ad8fd2
https://doi.org/10.1021/acs.jmedchem.0c00483
https://doi.org/10.1021/acs.jmedchem.0c00483
Autor:
Manjinder S, Lall, Asser, Bassyouni, James, Bradow, Maria, Brown, Mark, Bundesmann, Jinshan, Chen, Gregory, Ciszewski, Anne E, Hagen, Dennis, Hyek, Stephen, Jenkinson, Bo, Liu, R Scott, Obach, Senliang, Pan, Usa, Reilly, Neal, Sach, Daniel J, Smaltz, Douglas K, Spracklin, Jeremy, Starr, Melissa, Wagenaar, Gregory S, Walker
Publikováno v:
Journal of medicinal chemistry. 63(13)
An experimental approach is described for late-stage lead diversification of frontrunner drug candidates using nanomole-scale amounts of lead compounds for structure-activity relationship development. The process utilizes C-H bond activation methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64847a20d7e927f5644c919f79db1de5
https://pubmed.ncbi.nlm.nih.gov/32462865
https://pubmed.ncbi.nlm.nih.gov/32462865
Autor:
John O'Connell, Kevin J. Curran, Kristine Svenson, Anita Y. M. Howe, Kitae Lim, Steven F. Sukits, Mengxiao Shi, Ariamala Gopalsamy, Boris Feld, Girija Krishnamurthy, Rajiv Chopra, Tarek S. Mansour, Atul Agarwal, Mark Orlowski, Joel Bard, John W. Ellingboe, Gregory Ciszewski
Publikováno v:
Journal of Medicinal Chemistry. 49:3052-3055
Through high throughput screening, substituted proline sulfonamide 6 was identified as HCV NS5b RNA-dependent RNA polymerase inhibitor. Optimization of various regions of the lead molecule resulted in compounds that displayed good potency and selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dd28614e63376f9b254693c90ad648
https://doi.org/10.1021/jm060168g
https://doi.org/10.1021/jm060168g
Autor:
Gregory Ciszewski, John W. Ellingboe, Yelena Pyatski, Ariamala Gopalsamy, Tarek S. Mansour, Kaapjoo Park, Girija Krishnamurthy, Anita Y. M. Howe, Murthy Damarla, Janis Upeslacis, Douglas M. Ho, Boris Feld, Bloom Jonathan David, Kitae Lim, John O'Connell, Mark Orlowski, Shabana Insaf
Publikováno v:
Journal of Medicinal Chemistry. 47:6603-6608
A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c51eda846009d9fd6199330806a289e
https://doi.org/10.1021/jm0401255
https://doi.org/10.1021/jm0401255