Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy

Autor: Gregorio Naredo-Gonzalez, Rita Upreti, Maurits A. Jansen, Scott Semple, Oliver B. Sutcliffe, Ian Marshall, Brian R. Walker, Ruth Andrew

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) amplifies tissue glucocorticoid levels and is a pharmaceutical target in diabetes and cognitive decline. Clinical translation of inhibitors is hampered by lack of in vivo pharmacodynamic b

Externí odkaz: https://doaj.org/article/6a9028e7cc0f46658c806d04000708a5

Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by

Autor: Gregorio, Naredo-Gonzalez, Rita, Upreti, Maurits A, Jansen, Scott, Semple, Oliver B, Sutcliffe, Ian, Marshall, Brian R, Walker, Ruth, Andrew

Publikováno v: Scientific reports. 12(1)

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) amplifies tissue glucocorticoid levels and is a pharmaceutical target in diabetes and cognitive decline. Clinical translation of inhibitors is hampered by lack of in vivo pharmacodynamic biomarkers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf82f858fd80aac120d494399b3021b8
https://pubmed.ncbi.nlm.nih.gov/36175417

Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness

Autor: Sergio Rodriguez-Cuenca, Gary A. Churchill, Antonio Vidal-Puig, Maximilian Zeyda, Nicholas M. Morton, Annalisa Gastaldello, Jasmina Beltram, Scott P. Webster, Gregor Gorjanc, Aila Saari, Thomas M. Stulnig, Simon Horvat, Vilmundur Gudnason, Roderick N. Carter, Matthew T G Gibbins, José Manuel Fernández-Real, Jonathan R. Seckl, Steven C. Munger, Clare McFadden, Gregorio Naredo, Martin E. Barrios-Llerena, Donald R. Dunbar, Christopher J Kenyon, Zhao V. Wang, Alexander F. Howie, Lynne Ramage, José María Moreno-Navarrete, Karen L. Svenson, Brian R. Walker, Valur Emilsson, Petra Sipilä, Zoi Michailidou, Rhona Aird

Publikováno v: Morton, N M, Beltram, J, Carter, R N, Michailidou, Z, Gorjanc, G, McFadden, C, Barrios-Llerena, M E, Rodriguez-Cuenca, S, Gibbins, M T G, Aird, R E, Moreno-Navarrete, J M, Munger, S C, Svenson, K L, Gastaldello, A, Ramage, L, Naredo, G, Zeyda, M, Wang, Z V, Howie, A F, Saari, A, Sipilä, P, Stulnig, T M, Gudnason, V, Kenyon, C J, Seckl, J R, Walker, B R, Webster, S P, Dunbar, D R, Churchill, G A, Vidal-Puig, A, Fernandez-Real, J M, Emilsson, V & Horvat, S 2016, ' Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness ', Nature Medicine, vol. 22, no. 7, pp. 771-779 . https://doi.org/10.1038/nm.4115
Nature medicine
© Nature Medicine, 2016, vol. 22, p. 771-779
Articles publicats (D-CM)
DUGiDocs – Universitat de Girona
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The discovery of genetic mechanisms for resistance to obesity and diabetes may illuminate new therapeutic strategies for the treatment of this global health challenge. We used the polygenic 'lean' mouse model, which has been selected for low adiposit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d97883a5e7915270071cddd2f0f72e6
https://hdl.handle.net/2072/372198

A role for solvents in the toxicity of agricultural organophosphorus pesticides

Autor: Harald John, Horst Thiermann, Jonathan M. Street, John Harris, Michael Eddleston, Nicola Williams, Adrian Thompson, Gregorio Naredo, R Eddie Clutton, Kosala N. Dissanayake, Ly-Mee Yu, Franz Worek, Ian Self, Sionagh Smith, Tim King

Publikováno v: Eddleston, M, Street, J M, Self, I, Thompson, A, King, T, Williams, N, Naredo, G, Dissanayake, K, Yu, L M, Worek, F, John, H, Smith, S, Thiermann, H, Harris, J B & Clutton, R E 2012, ' A role for solvents in the toxicity of agricultural organophosphorus pesticides ', Toxicology, vol. 294, no. 2-3, pp. 94-103 . https://doi.org/10.1016/j.tox.2012.02.005
Toxicology

Organophosphorus (OP) insecticide self-poisoning is responsible for about one-quarter of global suicides. Treatment focuses on the fact that OP compounds inhibit acetylcholinesterase (AChE); however, AChE-reactivating drugs do not benefit poisoned hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab85750b7d76001676291ab8a957746
https://doi.org/10.1016/j.tox.2012.02.005

Quantitative analysis of an adrenal steroid profile, canrenone, and mifepristone in plasma by triple quadrupole mass spectrometry

Autor: Ruth Andrew, Gregorio Naredo, Catriona Kyle, Brian R. Walker, Natalie Z.M. Homer

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7cb9b3cdb04c4ef2bbd850bcf884833
https://doi.org/10.1530/endoabs.38.p406