Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Gregorio Fernández-Ballester"'
Autor:
David Alarcón-Alarcón, David Cabañero, Jorge de Andrés-López, Magdalena Nikolaeva-Koleva, Simona Giorgi, Gregorio Fernández-Ballester, Asia Fernández-Carvajal, Antonio Ferrer-Montiel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
A mouse model of chronic migraine reveals that males recover normal sensitivity before than females. This antinociception requires TRPM8 expression and presence of testosterone, which elicits currents and calcium transients via human and murine TRPM8
Externí odkaz:
https://doaj.org/article/adbc1cf476ac4e6e962929c4659d4034
Autor:
Cristina Martín-Escura, M. Ángeles Bonache, Jessy A. Medina, Alicia Medina-Peris, Jorge De Andrés-López, Sara González-Rodríguez, Sara Kerselaers, Gregorio Fernández-Ballester, Thomas Voets, Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Rosario González-Muñiz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14894 (2023)
The protein transient receptor potential melastatin type 8 (TRPM8), a non-selective, calcium (Ca2+)-permeable ion channel is implicated in several pathological conditions, including neuropathic pain states. In our previous research endeavors, we have
Externí odkaz:
https://doaj.org/article/7af6439c3de94c3eb426edb908d81259
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Chronic pain and pruritus are highly disabling pathologies that still lack appropriate therapeutic intervention. At cellular level the transduction and transmission of pain and pruritogenic signals are closely intertwined, negatively modulating each
Externí odkaz:
https://doaj.org/article/e7662a2f82104efa8e0be7002dfd427a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 743 (2023)
The thermosensory transient receptor potential (thermoTRP) family of ion channels is constituted by several nonselective cation channels that are activated by physical and chemical stimuli functioning as paradigmatic polymodal receptors. Gating of th
Externí odkaz:
https://doaj.org/article/ccd67d197b45419ca550c666e5270158
Autor:
Clara Blanes-Mira, Pilar Fernández-Aguado, Jorge de Andrés-López, Asia Fernández-Carvajal, Antonio Ferrer-Montiel, Gregorio Fernández-Ballester
Publikováno v:
Molecules, Vol 28, Iss 1, p 175 (2022)
The rapid advances of 3D techniques for the structural determination of proteins and the development of numerous computational methods and strategies have led to identifying highly active compounds in computer drug design. Molecular docking is a meth
Externí odkaz:
https://doaj.org/article/a34423f4ef554eb78d7fa26dfc7f73fa
Autor:
Cristina Martín-Escura, Alicia Medina-Peris, Luke A. Spear, Roberto de la Torre Martínez, Luis A. Olivos-Oré, María Victoria Barahona, Sara González-Rodríguez, Gregorio Fernández-Ballester, Asia Fernández-Carvajal, Antonio R. Artalejo, Antonio Ferrer-Montiel, Rosario González-Muñiz
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2692 (2022)
Transient receptor potential melastatin subtype 8 (TRPM8) is a cation channel extensively expressed in sensory neurons and implicated in different painful states. However, the effectiveness of TRPM8 modulators for pain relief is still a matter of dis
Externí odkaz:
https://doaj.org/article/5613252d0e764397832f81017e65505c
Autor:
Armando Alberola-Die, José Antonio Encinar, Raúl Cobo, Gregorio Fernández-Ballester, José Manuel González-Ros, Isabel Ivorra, Andrés Morales
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11287 (2021)
Fritillaria bulbs are used in Traditional Chinese Medicine to treat several illnesses. Peimine (Pm), an anti-inflammatory compound from Fritillaria, is known to inhibit some voltage-dependent ion channels and muscarinic receptors, but its interaction
Externí odkaz:
https://doaj.org/article/fe106dda45f64b919f7a013e1299f066
Autor:
María Ángeles Bonache, Pedro Juan Llabrés, Cristina Martín-Escura, Roberto De la Torre-Martínez, Alicia Medina-Peris, Laura Butrón, Isabel Gómez-Monterrey, Ana María Roa, Gregorio Fernández-Ballester, Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Rosario González-Muñiz
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2370 (2021)
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a Ca2+ non-selective ion channel implicated in a variety of pathological conditions, including cancer, inflammatory and neuropathic pain. In previous works we identified a fa
Externí odkaz:
https://doaj.org/article/c1d48ae9dd704112ac16cdd3da16777c
Autor:
Raúl Cobo, Magdalena Nikolaeva, Armando Alberola-Die, Gregorio Fernández-Ballester, José M. González-Ros, Isabel Ivorra, Andrés Morales
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Nicotinic acetylcholine (ACh) receptors (nAChRs) are included among the targets of a variety of local anesthetics, although the molecular mechanisms of blockade are still poorly understood. Some local anesthetics, such as lidocaine, act on nAChRs by
Externí odkaz:
https://doaj.org/article/ccd197914b5f450a86892ee1ba3afd4b
Autor:
Antonio Ferrer-Montiel, José Manuel González-Ros, Isabel Devesa, Asia Fernández-Carvajal, Gregorio Fernández-Ballester
Publikováno v:
Pharmaceuticals, Vol 5, Iss 1, Pp 16-48 (2011)
One approach to develop successful pain therapies is the modulation of dysfunctional ion channels that contribute to the detection of thermal, mechanical and chemical painful stimuli. These ion channels, known as thermoTRPs, promote the sensitization
Externí odkaz:
https://doaj.org/article/72d1de75920345358e2851c4ae56fade