The Plasmodium falciparum NCR1 transporter is an antimalarial target that exports cholesterol from the parasite's plasma membrane.

Autor: Zhang Z; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Lyu M; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Han X; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Bandara S; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Cui M; Department of Pharmaceutical Sciences, Northeastern University School of Pharmacy, Boston, MA 02115, USA., Istvan ES; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Geng X; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Tringides ML; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Gregor WD; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Miyagi M; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Oberstaller J; Center for Global Health and Infectious Diseases, Department of Global Health, University of South Florida, 3720 Spectrum Boulevard, Suite 404, Tampa, FL 33612, USA., Adams JH; Center for Global Health and Infectious Diseases, Department of Global Health, University of South Florida, 3720 Spectrum Boulevard, Suite 404, Tampa, FL 33612, USA., Zhang Y; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Nieman MT; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., von Lintig J; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Goldberg DE; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Yu EW; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Publikováno v: Science advances [Sci Adv] 2024 Dec 20; Vol. 10 (51), pp. eadq6651. Date of Electronic Publication: 2024 Dec 18.

Structures of the mycobacterial MmpL4 and MmpL5 transporters provide insights into their role in siderophore export and iron acquisition.

Autor: Maharjan R; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America., Zhang Z; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America., Klenotic PA; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America., Gregor WD; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America., Tringides ML; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America., Cui M; Department of Pharmaceutical Sciences, Northeastern University School of Pharmacy, Boston, Massachusetts, United States of America., Purdy GE; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America., Yu EW; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.

Publikováno v: PLoS biology [PLoS Biol] 2024 Oct 18; Vol. 22 (10), pp. e3002874. Date of Electronic Publication: 2024 Oct 18 (Print Publication: 2024).