Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Gregor Sturm"'
Autor:
Óscar Lapuente-Santana, Gregor Sturm, Joan Kant, Markus Ausserhofer, Constantin Zackl, Maria Zopoglou, Nicholas McGranahan, Dietmar Rieder, Zlatko Trajanoski, Noel Filipe da Cunha Carvalho de Miranda, Federica Eduati, Francesca Finotello
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110529- (2024)
Summary: The cellular and molecular heterogeneity of tumors is a major obstacle to cancer immunotherapy. Here, we use a systems biology approach to derive a signature of the main sources of heterogeneity in the tumor microenvironment (TME) from lung
Externí odkaz:
https://doaj.org/article/6177426cd53a47f8b485b6ac42525e16
Autor:
Daniel Morales Borràs, Sara Verbandt, Markus Ausserhofer, Gregor Sturm, Jinyeong Lim, Gil Arasa Verge, Isaure Vanmeerbeek, Raquel S. Laureano, Jannes Govaerts, Jenny Sprooten, Yourae Hong, Rebecca Wall, Gert De Hertogh, Xavier Sagaert, Gabriele Bislenghi, André D’Hoore, Albert Wolthuis, Francesca Finotello, Woong-Yang Park, Stefan Naulaerts, Sabine Tejpar, Abhishek D. Garg
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-30 (2023)
Abstract CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of immunotherapy against microsatellite stable (MSS) CRC is limited. Litt
Externí odkaz:
https://doaj.org/article/b6bbbd98e72c4ea192406d7073bc5f95
Autor:
Christina Plattner, Giorgia Lamberti, Peter Blattmann, Alexander Kirchmair, Dietmar Rieder, Zuzana Loncova, Gregor Sturm, Stefan Scheidl, Marieke Ijsselsteijn, Georgios Fotakis, Asma Noureen, Rebecca Lisandrelli, Nina Böck, Niloofar Nemati, Anne Krogsdam, Sophia Daum, Francesca Finotello, Antonios Somarakis, Alexander Schäfer, Doris Wilflingseder, Miguel Gonzalez Acera, Dietmar Öfner, Lukas A. Huber, Hans Clevers, Christoph Becker, Henner F. Farin, Florian R. Greten, Ruedi Aebersold, Noel F.C.C. de Miranda, Zlatko Trajanoski
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108399- (2023)
Summary: Precision oncology approaches for patients with colorectal cancer (CRC) continue to lag behind other solid cancers. Functional precision oncology—a strategy that is based on perturbing primary tumor cells from cancer patients—could provi
Externí odkaz:
https://doaj.org/article/e7b86d875dee498688afb5b6da71b4a9
Autor:
Kristina Koop, Karin Enderle, Miriam Hillmann, Laura Ruspeckhofer, Michael Vieth, Gregor Sturm, Zlatko Trajanoski, Anja A. Kühl, Raja Atreya, Moritz Leppkes, Patrick Baum, Janine Roy, Andrea Martin, Markus F. Neurath, Clemens Neufert
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundFibrostenotic disease is a common complication in Crohn’s disease (CD) patients hallmarked by transmural extracellular matrix (ECM) accumulation in the intestinal wall. The prevention and medical therapy of fibrostenotic CD is an unmet hi
Externí odkaz:
https://doaj.org/article/08cb77265210420bb89b921f76e186fd
Autor:
Leonie Wittner, Lukas Wagener, Jakob J. Wiese, Iris Stolzer, Susanne M. Krug, Elisabeth Naschberger, Rene Jackstadt, Rudi Beyaert, Raja Atreya, Anja A. Kühl, Gregor Sturm, Miguel Gonzalez-Acera, Jay V. Patankar, Christoph Becker, Britta Siegmund, Zlatko Trajanoski, Beate Winner, Markus F. Neurath, Michael Schumann, Claudia Günther
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7402 (2023)
The paracaspase MALT1 is a crucial regulator of immune responses in various cellular contexts. Recently, there is increasing evidence suggesting that MALT1 might represent a novel key player in mucosal inflammation. However, the molecular mechanisms
Externí odkaz:
https://doaj.org/article/f577382e6af3416e99287fc343607f9e
Autor:
Sjoerd H van der Burg, Thomas Höllt, Ziena Abdulrahman, Marieke E Ijsselsteijn, Noel F C C de Miranda, Dana A M Mustafa, Marij J P Welters, Zlatko Trajanoski, Saskia J Santegoets, Pornpimol Charoentong, Gregor Sturm, Antonios Somarakis, Francesca Finotello, Sylvia L van Egmond
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/f0029b590dda439cbaad7a04015bd7c8
Autor:
Sjoerd H van der Burg, Ramon Arens, Hubert Hackl, Ziena Abdulrahman, Ilina Ehsan, Mariette I E van Poelgeest, Marij J P Welters, Zlatko Trajanoski, Peter ten Dijke, Saskia J Santegoets, Gregor Sturm, Francesca Finotello, Chantal L Duurland, Nikki M Loof, Tom H Wesselink, Sanne Boekestijn, Veronique M Braud
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/03fe6d92883f4169a60a5722440cf6e5
Autor:
Saskia Santegoets, Thomas Höllt, Ziena Abdulrahman, Sjoerd van der Burg, Zlatko Trajanoski, Pornpimol Charoentong, Gregor Sturm, Marieke Ijsselsteijn, Antonios Somarakis, Francesca Finotello, Sylvia van Egmond, Dana Mustafa, Marij Welters, Noel de Miranda
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/bd2690d72df84212af7a10d67ce97f20
Autor:
Miguel Gonzalez Acera, Marvin Bubeck, Fabrizio Mascia, Leonard Diemand, Gregor Sturm, Anja A. Kühl, Raja Atreya, Dieter Chichung Lie, Markus F. Neurath, Michael Schumann, Christoph S.N. Klose, Zlatko Trajanoski, Christoph Becker, Jay V. Patankar
Publikováno v:
Cells, Vol 10, Iss 9, p 2253 (2021)
Inflammatory bowel diseases (IBD) are characterized by chronic dysregulation of immune homeostasis, epithelial demise, immune cell activation, and microbial translocation. Each of these processes leads to proinflammatory changes via the release of cy
Externí odkaz:
https://doaj.org/article/d6eddfb12d2f4f189d75b176b637e8f1
Autor:
Jitao David Zhang, Klas Hatje, Gregor Sturm, Clemens Broger, Martin Ebeling, Martine Burtin, Fabiola Terzi, Silvia Ines Pomposiello, Laura Badi
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-9 (2017)
Abstract Background Gene expression data can be compromised by cells originating from other tissues than the target tissue of profiling. Failures in detecting such tissue heterogeneity have profound implications on data interpretation and reproducibi
Externí odkaz:
https://doaj.org/article/e2f3d7cda6a14257b97e1a96f5781ae5