Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric acute lymphoblastic leukemia

Autor: Amanda C. Lorentzian, Jenna Rever, Enes K. Ergin, Meiyun Guo, Neha M. Akella, Nina Rolf, C. James Lim, Gregor S. D. Reid, Christopher A. Maxwell, Philipp F. Lange

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Childhood acute lymphoblastic leukemia (ALL) genomes show that relapses often arise from subclonal outgrowths. However, the impact of clonal evolution on the actionable proteome and response to targeted therapy is not known. Here, we present

Externí odkaz: https://doaj.org/article/ef6d2efa7bfe46babb83d0060edfc692

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

Autor: Anuli C. Uzozie, Enes K. Ergin, Nina Rolf, Janice Tsui, Amanda Lorentzian, Samuel S. H. Weng, Lorenz Nierves, Theodore G. Smith, C. James Lim, Christopher A. Maxwell, Gregor S. D. Reid, Philipp F. Lange

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-24 (2021)

Abstract Background Murine xenografts of pediatric leukemia accurately recapitulate genomic aberrations. How this translates to the functional capacity of cells remains unclear. Here, we studied global protein abundance, phosphorylation, and protein

Externí odkaz: https://doaj.org/article/d322bf218f4945d68e9218ca550e6200

A cross‐standardized flow cytometry platform to assess phenotypic stability in precursor B‐cell acute lymphoblastic leukemia (B‐ALL) xenografts

Autor: Nina Rolf, Suzanne Vercauteren, Gregor S. D. Reid, Angela Tsang, Christopher A. Maxwell, Philipp F. Lange, Chinten James Lim, Lorraine Liu

Publikováno v: Cytometry Part A. 101:57-71

With the continued poor outcome of relapsed acute lymphoblastic leukemia (ALL), new patient-specific approaches for disease progression monitoring and therapeutic intervention are urgently needed. Patient-derived xenografts (PDX) of primary ALL in im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ddac93b43b259e0259417ba2e2fece
https://doi.org/10.1002/cyto.a.24473

Vasoactive intestinal peptide promotes host defense against enteric pathogens by modulating the recruitment of group 3 innate lymphoid cells

Autor: Hyungjun Yang, Harry Sokol, Else S. Bosman, Franziska A. Graef, Gregor S. D. Reid, Joannie M. Allaire, Caixia Ma, Hongbing Yu, Lisa C. Osborne, Bruce A. Vallance, Kevan Jacobson, Arthur Mortha, Qiaochu Liang, James A. Waschek

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (41), ⟨10.1073/pnas.2106634118⟩
Proc Natl Acad Sci U S A

Group 3 innate lymphoid cells (ILC3s) control the formation of intestinal lymphoid tissues and play key roles in intestinal defense. They express neuropeptide vasoactive intestinal peptide (VIP) receptor 2 (VPAC2), through which VIP modulates their f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1557865fd0a6971c3104d95ec820c992
https://doi.org/10.1073/pnas.2106634118

Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts

Autor: Hyungjun Yang, Sébastien G. Gouin, Nicolas Barnich, Wayne Vogl, Gregor S. D. Reid, Bruce A. Vallance, Else S. Bosman, Hengameh Chloé Mirsepasi-Lauridsen, Caixia Ma, Karen A. Krogfelt, Adeline Sivignon, Xiaoxia Li, Carsten Struve, Andreas Petersen, Hongbing Yu, Kevan Jacobson, Abbas Fotovati, Joannie M. Allaire

Publikováno v: Gut Microbes, Vol 12, Iss 1 (2020)
Gut Microbes
article-version (VoR) Version of Record
Journal of Immunology
Journal of Immunology, 2020, 12 (1), pp.1-20. ⟨10.1080/19490976.2020.1847976⟩
Gut microbes
Gut microbes, Taylor & Francis, 2020, pp.1-19. ⟨10.1080/19490976.2020.1847976⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2020, 12 (1), pp.1-20. ⟨10.1080/19490976.2020.1847976⟩
Yang, H, Mirsepasi-Lauridsen, H C, Struve, C, Allaire, J M, Sivignon, A, Vogl, W, Bosman, E S, Ma, C, Fotovati, A, Reid, G S, Li, X, Petersen, A M, Gouin, S G, Barnich, N, Jacobson, K, Yu, H B, Krogfelt, K A & Vallance, B A 2020, ' Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts ', Gut Microbes, vol. 12, no. 1, 1847976 . https://doi.org/10.1080/19490976.2020.1847976

International audience; Ulcerative colitis (UC) is a chronic inflammatory condition linked to intestinal microbial dysbiosis, including the expansion of E. coli strains related to extra-intestinal pathogenic E. coli. These "pathobionts" exhibit patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb798f8c1c38d8a0b2c6c20e079167b
https://doaj.org/article/07f63ac643414f119424c94c5a08b3e7