Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gregor Jezernik"'
Autor:
Mario Gorenjak, Boris Gole, Larisa Goričan, Gregor Jezernik, Uršula Prosenc Zmrzljak, Cvetka Pernat, Pavel Skok, Uroš Potočnik
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 835 (2024)
Background: The lack of reliable biomarkers in response to anti-TNFα biologicals hinders personalized therapy for Crohn’s disease (CD) patients. The motivation behind our study is to shift the paradigm of anti-TNFα biomarker discovery toward spec
Externí odkaz:
https://doaj.org/article/77b5d66814184be3a02815a3949fb73d
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2024 (2023)
Psoriasis is a chronic, immune-mediated and inflammatory skin disease. Although various biological drugs are available for psoriasis treatment, some patients have poor responses or do not respond to treatment. The aim of the present study was to high
Externí odkaz:
https://doaj.org/article/fbc28cb1b2584f52b3d1c2e4e4301580
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Response to anti-TNF therapy is of pivotal importance in patients with Crohn’s disease (CD). Here we integrated our and previously reported PBMC derived transcriptomic and genomic data for identification of biomarkers for discrimination be
Externí odkaz:
https://doaj.org/article/b2f36ff16073409a88a0ed13697147e8
Publikováno v:
Genes, Vol 14, Iss 2, p 452 (2023)
Crohn’s disease (CD), rheumatoid arthritis, psoriatic arthritis and other inflammatory diseases comprise a group of chronic diseases with immune-mediated pathogenesis which share common pathological pathways, as well as treatment strategies includi
Externí odkaz:
https://doaj.org/article/9ab88a7e40de4b919cb60693fda66b2f
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1893 (2022)
Crohn’s disease is a consequence of dysregulated inflammatory response to the host’s microbiota. Although anti-TNF treatment improves the quality of the patient’s life, a large proportion of patients lose response to the treatment. The past dec
Externí odkaz:
https://doaj.org/article/f4461e61510748fcb58716c46949768e
Publikováno v:
Cancers, Vol 14, Iss 19, p 4681 (2022)
Background: Acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) represent a group of hematological malignancies characterized by the pathogenic clonal expansion of leukemic myeloid cells. The diagnosis and clinical outcome of AML and CML
Externí odkaz:
https://doaj.org/article/450f9a8efda9460aabc5f0d312e7aaca
Autor:
Damjan Glavač, Miranda Mladinić, Jelena Ban, Graciela L. Mazzone, Cynthia Sámano, Ivana Tomljanović, Gregor Jezernik, Metka Ravnik-Glavač
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11360 (2022)
Neurodegenerative diseases are one of the greatest medical burdens of the modern age, being mostly incurable and with limited prognostic and diagnostic tools. Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease chara
Externí odkaz:
https://doaj.org/article/f27021b138d944b3af8ed8454d26b424
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 1808 (2022)
Anti-TNF therapy has significantly improved disease control in rheumatoid arthritis, but a fraction of rheumatoid arthritis patients do not respond to anti-TNF therapy or lose response over time. Moreover, the mechanisms underlying non-response to an
Externí odkaz:
https://doaj.org/article/91bb0105be7d487d8f69c7f55faa6db2
Autor:
Kristijan Skok, Lidija Gradišnik, Helena Čelešnik, Marko Milojević, Uroš Potočnik, Gregor Jezernik, Mario Gorenjak, Monika Sobočan, Iztok Takač, Rajko Kavalar, Uroš Maver
Publikováno v:
Cells, Vol 11, Iss 1, p 117 (2021)
Triple-negative breast cancer (TNBC) is a breast cancer (BC) subtype that accounts for approximately 15–20% of all BC cases. Cancer cell lines (CLs) provide an efficient way to model the disease. We have recently isolated a patient-derived triple-n
Externí odkaz:
https://doaj.org/article/0e7b095ae289474e939a92ddcdb745c3
Publikováno v:
Journal of Personalized Medicine, Vol 10, Iss 4, p 243 (2020)
Inflammatory bowel disease (IBD) manifests as a complex disease resulting from gene–environment interactions or as a monogenic disease resulting from deleterious mutations. While monogenic IBD is predominantly pediatric, only one-quarter of complex
Externí odkaz:
https://doaj.org/article/c9385fc3846e4c1ca29a796198447ec7