Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Gregor Jansen"'
Autor:
Marion Maurel, Joanna Obacz, Tony Avril, Yong‐Ping Ding, Olga Papadodima, Xavier Treton, Fanny Daniel, Eleftherios Pilalis, Johanna Hörberg, Wenyang Hou, Marie‐Claude Beauchamp, Julien Tourneur‐Marsille, Dominique Cazals‐Hatem, Lucia Sommerova, Afshin Samali, Jan Tavernier, Roman Hrstka, Aurélien Dupont, Delphine Fessart, Frédéric Delom, Martin E Fernandez‐Zapico, Gregor Jansen, Leif A Eriksson, David Y Thomas, Loydie Jerome‐Majewska, Ted Hupp, Aristotelis Chatziioannou, Eric Chevet, Eric Ogier‐Denis
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 6, Pp 1-19 (2019)
Abstract Anterior gradient 2 (AGR2) is a dimeric protein disulfide isomerase family member involved in the regulation of protein quality control in the endoplasmic reticulum (ER). Mouse AGR2 deletion increases intestinal inflammation and promotes the
Externí odkaz:
https://doaj.org/article/2b0499d0c4e74f49840a1110c75b673e
Autor:
Gregor Jansen, Anna Y Lee, Elias Epp, Amélie Fredette, Jamie Surprenant, Doreen Harcus, Michelle Scott, Elaine Tan, Tamiko Nishimura, Malcolm Whiteway, Michael Hallett, David Y Thomas
Publikováno v:
Molecular Systems Biology, Vol 5, Iss 1, Pp 1-13 (2009)
Abstract Chemotherapies, HIV infections, and treatments to block organ transplant rejection are creating a population of immunocompromised individuals at serious risk of systemic fungal infections. Since single‐agent therapies are susceptible to fa
Externí odkaz:
https://doaj.org/article/d304a14adf0e4f5ebae26e5db0a183d8
Autor:
Elias Epp, Ghyslaine Vanier, Doreen Harcus, Anna Y Lee, Gregor Jansen, Michael Hallett, Don C Sheppard, David Y Thomas, Carol A Munro, Alaka Mullick, Malcolm Whiteway
Publikováno v:
PLoS Pathogens, Vol 6, Iss 2, p e1000753 (2010)
Candida albicans, the major fungal pathogen of humans, causes life-threatening infections in immunocompromised individuals. Due to limited available therapy options, this can frequently lead to therapy failure and emergence of drug resistance. To imp
Externí odkaz:
https://doaj.org/article/e0fc33be978240cdb11ed15d4e4d4ff3
Autor:
Jacqueline Melissa Hsiao, Ylauna Christine Mégane Penalva, Helen Yee-Li Wu, Bin Xiao, Gregor Jansen, Kurt Dejgaard, Jason C. Young, Lisa Marie Munter
Publikováno v:
Biochemistry. 62:1209-1218
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0a64b7b1e3736efeb43c78b81f90883
https://doi.org/10.1021/acs.biochem.2c00680
https://doi.org/10.1021/acs.biochem.2c00680
Autor:
Jason C. Young, Yukiko Sato, David Y. Thomas, Graeme W. Carlile, John W. Hanrahan, Gregor Jansen
Publikováno v:
Expert opinion on therapeutic targets. 23(8)
Introduction: Cystic fibrosis (CF) is the most frequent lethal orphan disease and is caused by mutations in the CFTR gene. The most frequent mutation F508del-CFTR affects multiple organs; infections and subsequent infections and complications in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7799afb6f7c583f3c989356ee423740
https://pubmed.ncbi.nlm.nih.gov/31169041
https://pubmed.ncbi.nlm.nih.gov/31169041
Publikováno v:
Methods in Molecular Biology ISBN: 9781493930517
Many biological processes are regulated by protein-protein interactions, and the analysis of these interactions has been a productive endeavor contributing to our understanding of cellular organization and function. The yeast two-hybrid technique is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1c9a19850687545e775db8e013e6e55
https://doi.org/10.1007/978-1-4939-3052-4_3
https://doi.org/10.1007/978-1-4939-3052-4_3
Publikováno v:
Science. 321:569-572
Membrane and secretory proteins cotranslationally enter and are folded in the endoplasmic reticulum (ER). Misfolded or unassembled proteins are discarded by a process known as ER-associated degradation (ERAD), which involves their retrotranslocation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25b76923d95046f5101522baa21d75a
https://doi.org/10.1126/science.1159293
https://doi.org/10.1126/science.1159293
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1356
Many biological processes are regulated by protein-protein interactions, and the analysis of these interactions has been a productive endeavor contributing to our understanding of cellular organization and function. The yeast two-hybrid technique is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2ce9f0f3ec9af790ab45c2f2f96098d
https://pubmed.ncbi.nlm.nih.gov/26519063
https://pubmed.ncbi.nlm.nih.gov/26519063
Autor:
Youla S. Tsantrizos, Kurt Dejgaard, Lekha Sleno, David Y. Thomas, Daniel D Waller, René Roy, Tze Chieh Shiao, Gregor Jansen, Makan Golizeh, Michael Sebag, Chloe Martel-Lorion, John Mancuso
Publikováno v:
Chembiochem : a European journal of chemical biology. 17(9)
The unfolded protein response (UPR) initiated by the transmembrane kinase/ribonuclease Ire1 has been implicated in a variety of diseases. Ire1, with its unique position in the UPR, is an ideal target for the development of therapies; however, the ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc62f3308db6b8bca6a410afe2682c3
https://pubmed.ncbi.nlm.nih.gov/26792008
https://pubmed.ncbi.nlm.nih.gov/26792008
Publikováno v:
Genes & Development. 20:734-746
In a variety of yeast cellular pathways, the Ste50p protein regulates the kinase function of the mitogen extracellular signal-regulated kinase kinase (MEKK) Ste11p. Both Ste11p and Ste50p contain sterile α motif (SAM) domains; these are interchangea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c06e060545da3141efca2fc3d033f98
https://doi.org/10.1101/gad.1375706
https://doi.org/10.1101/gad.1375706