Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Gregor B. Adams"'
Autor:
Xiaoying Zhou, Amanda L. Crow, Jaana Hartiala, Tassja J. Spindler, Anatole Ghazalpour, Lora W. Barsky, Brian J. Bennett, Brian W. Parks, Eleazar Eskin, Rajan Jain, Jonathan A. Epstein, Aldons J. Lusis, Gregor B. Adams, Hooman Allayee
Publikováno v:
Stem Cell Reports, Vol 5, Iss 1, Pp 125-138 (2015)
Prior efforts to identify regulators of hematopoietic stem cell physiology have relied mainly on candidate gene approaches with genetically modified mice. Here we used a genome-wide association study (GWAS) strategy with the hybrid mouse diversity pa
Externí odkaz:
https://doaj.org/article/0fe47098e40f45b4a936fae57550093c
Autor:
Sarit Tabak, David Bassan, Leehee Weinberger, Jason Yi, Tanya Kim, Caitlin Schnair, Kristina Vucci, Neta Chaim, Nir Bujanover, Yael Lopesco, Orit Foord, Adi Sharbi-Yunger, Michael R Weist, Gregor B Adams, Limor Levy-Knafo, Richard L Kendall, Frank J Calzone
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)
Background One of the major challenges in chimeric antigen receptor (CAR)-T cell therapy for solid tumors is the potential for on-target off-tumor toxicity due to the expression of CAR tumor antigens in essential tissues and organs. Here, we describe
Externí odkaz:
https://doaj.org/article/5bdd2400c00d4244be00e6c3a41bb971
Autor:
David Bassan, Jason Yi, Neta Chaim, Nir Bujanover, Sarit Tabak, Tanya Kim, Yael Lopesco, Leehee Weinberger, Kristina Vucci, Michael Weist, Caitlin Schnair, Gregor B. Adams, Orit Foord, Frank J. Calzone, Rick Kendall, Adi Sharbi-Yunger
Publikováno v:
Cancer Research. 82:2848-2848
Chimeric antigen receptor (CAR)-T cell therapy is a groundbreaking cancer treatment that has produced remarkable clinical efficacy for hematopoietic malignancies, yet “on-target off-tumor” toxicity due to lack of target specificity limits the the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0235e605664efb72bf53e751922b8c6d
https://doi.org/10.1158/1538-7445.am2022-2848
https://doi.org/10.1158/1538-7445.am2022-2848
Autor:
Michael R. Weist, Adi Sharbi-Yunger, Jason Yi, Caitlin Schnair, David Bassan, Tanya Kim, Sarit Tabak, Yael Lopesco, Leehee Weinberger, Nir Bujanover, Neta Chaim, Kristina Vucci, Orit Foord, Frank J. Calzone, Rick Kendall, Gregor B. Adams
Publikováno v:
Cancer Research. 82:2826-2826
Translation of the unprecedented efficacy of chimeric antigen receptor (CAR) T-cell technology into solid tumors requires a solution to the problem of on-target damage of vital organs. We have developed an inhibitory CAR platform (iCAR) that imposes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac4890e97c5585c8bbf01761d6db7e3d
https://doi.org/10.1158/1538-7445.am2022-2826
https://doi.org/10.1158/1538-7445.am2022-2826
Publikováno v:
Stem Cells and Development. 23:434-441
Mesenchymal stem cells (MSCs), as well as osteoblastic cells derived from these MSCs, have been shown to be key components of the hematopoietic stem cell (HSC) niche. In this study, we wished to examine whether other cell types that are known to diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13eea04d7ac2aa53560dbb88b8c83f7
https://doi.org/10.1089/scd.2013.0227
https://doi.org/10.1089/scd.2013.0227
Autor:
Meidan Ying, Hiroyuki Shimada, Gang Liu, Qiaojun He, William A. May, Gregor B. Adams, Wanjing Ding, Lingtao Wu
Publikováno v:
Oncogene
The biological relationships among self-renewal, tumorigenicity and lineage differentiation of human osteosarcoma-initiating cells (OSIC) remain elusive, making it difficult to identify and distinguish OSIC from osteosarcoma-forming cells (OSFC) for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef10ef8ffb6476dcd3bc26260d9a23da
http://europepmc.org/articles/PMC3947577
http://europepmc.org/articles/PMC3947577
Autor:
Gregor B. Adams, Ben S. Lam
Publikováno v:
International Journal of Laboratory Hematology. 32:551-558
Treatment of malignant blood disorders, such as leukemia, that can provide a better chance of long-term remission involves myeloablation followed by transplantation of matched donor hematopoietic stem cells (HSCs). For successful engraftment and re-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4c801c009562c0fea22bfbc0017e9a5
https://doi.org/10.1111/j.1751-553x.2010.01250.x
https://doi.org/10.1111/j.1751-553x.2010.01250.x
Autor:
Christine Sastri, Alice Bakker, Rebecca Goldstein, Yan Zheng, Angela Coxon, Armen Mardiros, Priya Koppikar, Bettina Lindl, Anthony Polverino, Gregor B. Adams, Marion Subklewe, Wu Lawren, Herve Lebrec, Mercedesz Balazs, Dan A. Rock, Chi Ming Li, Tara Arvedson, Mei Gong
Publikováno v:
Cancer Research. 78:2559-2559
Background: FLT3 (CD135) is a receptor tyrosine kinase expressed by hematopoietic progenitor cells, and when activated by ligand binding, FLT3 signaling can induce survival, proliferation and differentiation. Acute myeloid leukemia (AML), an indicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f06a8d1f72ce589e5d68f80df74d4f50
https://doi.org/10.1158/1538-7445.am2018-2559
https://doi.org/10.1158/1538-7445.am2018-2559
Autor:
Gregor B. Adams, Narges Rashidi
Publikováno v:
Current Osteoporosis Reports. 7:53-57
Adult hematopoietic stem cells (HSCs) reside in the bone marrow in stable microenvironments known as the stem cell niche. One key component of the stem cell niche is cells of the osteoblastic lineage. Factors that are known to affect osteoblast activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf2c1cee4d366fad3719cc9c4b0649a
https://doi.org/10.1007/s11914-009-0010-7
https://doi.org/10.1007/s11914-009-0010-7
Autor:
Lee S. Weinstein, Cristina Lo Celso, Ian R. Alley, Gregor B. Adams, Ung-il Chung, Min Chen, Charles P. Lin, Emily S. Marsters, Nathaniel T. Jeanson, David T. Scadden, Henry M. Kronenberg, Karissa T. Chabner
Publikováno v:
Nature
Haematopoietic stem and progenitor cells (HSPCs) change location during development and circulate in mammals throughout life, moving into and out of the bloodstream to engage bone marrow niches in sequential steps of homing, engraftment and retention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b24454e0fc67a88e57b04dc20ed0d36
http://europepmc.org/articles/PMC2761017
http://europepmc.org/articles/PMC2761017