Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Gregg Siegal"'
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 15, p 3684 (2019)
The divisome is a large protein complex that regulates bacterial cell division and therefore represents an attractive target for novel antibacterial drugs. In this study, we report on the ligandability of FtsQ, which is considered a key component of
Externí odkaz:
https://doaj.org/article/f915e755e15545e6817fb790b0923f54
Autor:
Peter O'Brien, Eleni Makraki, Alex Heyam, Eiso Ab, Gregg Siegal, John F. Darby, James D. Firth, Marta G Carneiro, Roderick E. Hubbard
Publikováno v:
Makraki, E, Darby, J F, Carneiro, M G, Firth, J D, Heyam, A, Ab, E, O'Brien, P, Siegal, G & Hubbard, R E 2020, ' Fragment-derived modulators of an industrial β-glucosidase ', The Biochemical journal, vol. 477, no. 22, pp. 4383-4395 . https://doi.org/10.1042/BCJ20200507
The Biochemical journal, 477(22), 4383-4395
Biochemical Journal
The Biochemical journal, 477(22), 4383-4395
Biochemical Journal
A fragment screen of a library of 560 commercially available fragments using a kinetic assay identified a small molecule that increased the activity of the fungal glycoside hydrolase TrBgl2. An analogue by catalogue approach and detailed kinetic anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6438d6def194e76b2aeff87c11be04
https://hdl.handle.net/1871.1/7fa3c6bc-6a2b-42e3-97fa-f8b4a8dd66d8
https://hdl.handle.net/1871.1/7fa3c6bc-6a2b-42e3-97fa-f8b4a8dd66d8
Autor:
Gregg Siegal, Marta G. Carneiro, Denys Pogoryelev, Stephan Theisgen, Johan Hollander, Masakazu Kobayashi, Eiso Ab, Sébastien Keiffer, Gerhard Müller
Publikováno v:
Keiffer, S, Carneiro, M G, Hollander, J, Kobayashi, M, Pogoryelev, D, Ab, E, Theisgen, S, Müller, G & Siegal, G 2020, ' NMR in target driven drug discovery : why not? ', Journal of Biomolecular NMR, vol. 74, no. 10-11, pp. 521-529 . https://doi.org/10.1007/s10858-020-00343-9
Journal of Biomolecular NMR, 74(10-11), 521-529. Springer Netherlands
Journal of Biomolecular Nmr
Journal of Biomolecular NMR, 74(10-11), 521-529. Springer Netherlands
Journal of Biomolecular Nmr
No matter the source of compounds, drug discovery campaigns focused directly on the target are entirely dependent on a consistent stream of reliable data that reports on how a putative ligand interacts with the protein of interest. The data will deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2e8343bd3c75e85849e698c5c314cf
https://hdl.handle.net/1871.1/bae125de-2537-4784-92ee-a1d6ed291250
https://hdl.handle.net/1871.1/bae125de-2537-4784-92ee-a1d6ed291250
Publikováno v:
Makraki, E, Carneiro, M G, Heyam, A, Eiso, A B, Siegal, G & Hubbard, R E 2020, ' 1 H, 13 C, 15 N backbone and IVL methyl group resonance assignment of the fungal β-glucosidase from Trichoderma reesei ', Biomolecular NMR Assignments, vol. 14, no. 2, pp. 265-268 . https://doi.org/10.1007/s12104-020-09959-2
Biomolecular Nmr Assignments
Biomolecular NMR Assignments, 14(2), 265-268. Springer Netherlands
Biomolecular Nmr Assignments
Biomolecular NMR Assignments, 14(2), 265-268. Springer Netherlands
β-glucosidases have received considerable attention due to their essential role in bioethanol production from lignocellulosic biomass. β-glucosidase can hydrolyse cellobiose in cellulose degradation and its low activity has been considered as one o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac1e2b41f06ecf93853010d4baa9089
https://hdl.handle.net/1871.1/03ab6ca5-e856-4f98-b429-721582aeca45
https://hdl.handle.net/1871.1/03ab6ca5-e856-4f98-b429-721582aeca45
Publikováno v:
Essays in Biochemistry. 61:485-493
NMR spectroscopy is a powerful technique that can provide valuable structural information for drug discovery endeavors. Here, we discuss the strengths (and limitations) of NMR applications to structure-based drug discovery, highlighting the different
Publikováno v:
Biomolecular Nmr Assignments
In the original publication of the article, the name of one of the authors is incorrect. The author's name is Eiso AB, but was modified to A. B. Eiso. The correct name is given in this Correction.
Autor:
Iwan J. P. de Esch, Maarten H. Vermeer, Jacoba J. Out-Luiting, Cornelis P. Tensen, Leslie van der Fits, Gregg Siegal, Willem H. Zoutman, Liesbeth Hameetman
Publikováno v:
Oncotarget
Oncotarget, 6(31), 31868-31876
Oncotarget, 6(31), 31868-31876. Impact Journals
Hameetman, L, van der Fits, L, Zoutman, W H, Out-Luiting, J J, Siegal, G, de Esch, I J P, Vermeer, M H & Tensen, C P 2015, ' EPHA4 is overexpressed but not functionally active in Sezary syndrome ', Oncotarget, vol. 6, no. 31, pp. 31868-31876 . https://doi.org/10.18632/oncotarget.5573
Oncotarget, 6(31), 31868-31876
Oncotarget, 6(31), 31868-31876. Impact Journals
Hameetman, L, van der Fits, L, Zoutman, W H, Out-Luiting, J J, Siegal, G, de Esch, I J P, Vermeer, M H & Tensen, C P 2015, ' EPHA4 is overexpressed but not functionally active in Sezary syndrome ', Oncotarget, vol. 6, no. 31, pp. 31868-31876 . https://doi.org/10.18632/oncotarget.5573
// Liesbeth Hameetman 1 , Leslie van der Fits 1 , Willem H. Zoutman 1 , Jacoba J. Out-Luiting 1 , Gregg Siegal 2 , Iwan J.P. de Esch 3 , Maarten H. Vermeer 1 and Cornelis P. Tensen 1 1 Department of Dermatology, Leiden University Medical Center, Leid
Autor:
Andrew Baldwin, Gregg Siegal, T. Reid Alderson, Matteo T. Degiacomi, Iva Pritišanac, Marta G Carneiro, Eiso Ab
Publikováno v:
Journal of the American Chemical Society. 139(28)
Methyl groups are powerful probes for the analysis of structure, dynamics and function of supramolecular assemblies, using both solution- and solid-state NMR. Widespread application of the methodology has been limited due to the challenges associated
Publikováno v:
Journal of Chemical Information and Modeling. 53:2701-2714
Fragment-based lead discovery (FBLD) is becoming an increasingly important method in drug development. We have explored the potential to complement NMR-based biophysical screening of chemical libraries with molecular docking in FBLD against the A(2A)
Publikováno v:
Farenc, C, Celie, C, Tensen, P H N, de Esch, I J P & Siegal, C P 2011, ' Crystal structure of the EphA4 protein tyrosine kinase domain in the apo-and dasantinib-bound state ', FEBS Letters, vol. 16, no. 585, pp. 3593-3599 . https://doi.org/10.1016/j.febslet.2011.10.028
FEBS Letters, 16(585), 3593-3599. Elsevier
FEBS Letters, 585(22), 3593-3599
FEBS Letters, 16(585), 3593-3599. Elsevier
FEBS Letters, 585(22), 3593-3599
The Eph family of receptor tyrosine kinases regulates diverse cellular processes while the over-expression of a member of this family, EphA4, has been reported in a variety of malignant carcinomas. To gain insight into molecular mechanisms and to fac