ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation.

Autor: Czerwińska J; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland. Electronic address: jczerwinska@ibb.waw.pl., Nowak M; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland. Electronic address: malgorzata.nowak.eu@gmail.com., Wojtczak P; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland. Electronic address: patrycja.m.wojtczak@gmail.com., Dziuban-Lech D; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland. Electronic address: dziuban@ibb.waw.pl., Cieśla JM; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland. Electronic address: castor@ibb.waw.pl., Kołata D; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland. Electronic address: d.kolata@op.pl., Gajewska B; Department of Biochemistry, Medical University of Warsaw, Warsaw, Poland. Electronic address: bgajewska@wum.edu.pl., Barańczyk-Kuźma A; Department of Biochemistry, Medical University of Warsaw, Warsaw, Poland. Electronic address: akuzma@wum.edu.pl., Robinson AR; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA, USA. Electronic address: rasileae@yahoo.com., Shane HL; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA, USA. Electronic address: shaneh@pitt.edu., Gregg SQ; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA, USA; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: siobhan.gregg@gmail.com., Rigatti LH; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA, USA. Electronic address: rigattil@pitt.edu., Yousefzadeh MJ; Department of Molecular Medicine, Center on Aging, The Scripps Research Institute, Jupiter, FL, USA. Electronic address: myousefz@scripps.edu., Gurkar AU; Department of Molecular Medicine, Center on Aging, The Scripps Research Institute, Jupiter, FL, USA. Electronic address: agurkar1@pitt.edu., McGowan SJ; Department of Molecular Medicine, Center on Aging, The Scripps Research Institute, Jupiter, FL, USA. Electronic address: smcgowan@scripps.edu., Kosicki K; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland. Electronic address: konrado@biol.uw.edu.pl., Bednarek M; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland. Electronic address: bednarekmj@gmail.com., Zarakowska E; Department of Clinical Biochemistry, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland. Electronic address: ewelinaz@cm.umk.pl., Gackowski D; Department of Clinical Biochemistry, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland. Electronic address: danielg@cm.umk.pl., Oliński R; Department of Clinical Biochemistry, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland. Electronic address: ryszardo@cm.umk.pl., Speina E; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland. Electronic address: elasp@ibb.waw.pl., Niedernhofer LJ; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA, USA; Department of Molecular Medicine, Center on Aging, The Scripps Research Institute, Jupiter, FL, USA. Electronic address: lniedern@scripps.edu., Tudek B; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland. Electronic address: tudek@ibb.waw.pl.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2018 Aug 20; Vol. 124, pp. 79-96. Date of Electronic Publication: 2018 Jun 01.

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.

Autor: Robinson AR; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Yousefzadeh MJ; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Rozgaja TA; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Wang J; Department of Chemistry, University of California, Riverside, CA 92521, USA., Li X; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Tilstra JS; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Feldman CH; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA., Gregg SQ; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Johnson CH; The Scripps Research Institute California, La Jolla, CA 92037, USA., Skoda EM; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA., Frantz MC; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA., Bell-Temin H; Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Pope-Varsalona H; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15213, USA., Gurkar AU; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Nasto LA; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Paediatric Orthopaedics, G. Gaslini Children's Hospital, Genoa, Italy., Robinson RAS; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA., Fuhrmann-Stroissnigg H; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Czerwinska J; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland., McGowan SJ; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Cantu-Medellin N; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA., Harris JB; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA., Maniar S; Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Ross MA; Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Trussoni CE; Division of Gastroenterology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA., LaRusso NF; Division of Gastroenterology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA., Cifuentes-Pagano E; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Pagano PJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Tudek B; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland., Vo NV; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA., Rigatti LH; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA., Opresko PL; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15213, USA., Stolz DB; Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Watkins SC; Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Burd CE; Department of Molecular Genetics, Cancer Biology and Genetics, The Ohio State University, Columbus OH 43210 USA., Croix CMS; Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Siuzdak G; The Scripps Research Institute California, La Jolla, CA 92037, USA., Yates NA; Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Biomedical Mass Spectrometry Center, Schools of the Health Sciences University of Pittsburgh, Pittsburgh, PA 15213, USA., Robbins PD; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA., Wang Y; Department of Chemistry, University of California, Riverside, CA 92521, USA., Wipf P; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA., Kelley EE; Department of Physiology & Pharmacology, West Virginia University, Morgantown, WV 26506, USA. Electronic address: eric.kelley@hsc.wvu.edu., Niedernhofer LJ; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address: lniedern@scripps.edu.

Publikováno v: Redox biology [Redox Biol] 2018 Jul; Vol. 17, pp. 259-273. Date of Electronic Publication: 2018 Apr 13.

Identification of HSP90 inhibitors as a novel class of senolytics.

Autor: Fuhrmann-Stroissnigg H; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA., Ling YY; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA., Zhao J; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA., McGowan SJ; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA., Zhu Y; University of Pittsburgh School of Medicine, Pittsburgh, 15261, PA, USA., Brooks RW; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA., Grassi D; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA., Gregg SQ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, 55905, MN, USA., Stripay JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, 55905, MN, USA., Dorronsoro A; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA., Corbo L; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA., Tang P; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA., Bukata C; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA., Ring N; International Centre for Genetic Engineering and Biotechnology, Trieste, 34100, Italy., Giacca M; International Centre for Genetic Engineering and Biotechnology, Trieste, 34100, Italy., Li X; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA., Tchkonia T; University of Pittsburgh School of Medicine, Pittsburgh, 15261, PA, USA., Kirkland JL; University of Pittsburgh School of Medicine, Pittsburgh, 15261, PA, USA., Niedernhofer LJ; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA., Robbins PD; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, 33458, FL, USA. probbins@scripps.edu.

Publikováno v: Nature communications [Nat Commun] 2017 Sep 04; Vol. 8 (1), pp. 422. Date of Electronic Publication: 2017 Sep 04.

A mouse model of accelerated liver aging caused by a defect in DNA repair.

Autor: Gregg SQ; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Gutiérrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2012 Feb; Vol. 55 (2), pp. 609-21.

Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease.

Autor: Gregg SQ; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Robinson AR, Niedernhofer LJ

Publikováno v: DNA repair [DNA Repair (Amst)] 2011 Jul 15; Vol. 10 (7), pp. 781-91. Date of Electronic Publication: 2011 May 25.