Zobrazeno 1 - 10
of 573
pro vyhledávání: '"Gregg L, Semenza"'
Autor:
Yajing Lyu, Yongkang Yang, Varen Talwar, Haiquan Lu, Chelsey Chen, Shaima Salman, Elizabeth E. Wicks, Tina Yi-Ting Huang, Daiana Drehmer, Yufeng Wang, Qiaozhu Zuo, Emmanuel Datan, Walter Jackson, III, Dominic Dordai, Ru Wang, Gregg L. Semenza
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113972- (2024)
Summary: Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates cellular adaptation to decreased oxygen availability. HIF-1 recruits chromatin-modifying enzymes leading to changes in histone acetylation, citrullination, and m
Externí odkaz:
https://doaj.org/article/81c1beb3ca954c18aaff5e6ff94c9e4a
Autor:
Jing Zhang, Deepti Sharma, Aumreetam Dinabandhu, Jaron Sanchez, Brooks Applewhite, Kathleen Jee, Monika Deshpande, Miguel Flores-Bellver, Ming-Wen Hu, Chuanyu Guo, Shaima Salman, Yousang Hwang, Nicole M. Anders, Michelle A. Rudek, Jiang Qian, M. Valeria Canto-Soler, Gregg L. Semenza, Silvia Montaner, Akrit Sodhi
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Many patients with diabetic eye disease respond inadequately to anti-VEGF therapies, implicating additional vasoactive mediators in its pathogenesis. We demonstrate that levels of angiogenic proteins regulated by HIF-1 and -2 remain elevated in the e
Externí odkaz:
https://doaj.org/article/208f02b363f54dcab967e446a3a95992
Autor:
Josef T. Prchal, Gregg L. Semenza
Publikováno v:
Haematologica, Vol 108, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/32a21dfa1b554a05950d03b699d8ee31
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that modulates target gene expression in response to changes in oxygen availability. Here the authors show that HIF-1 forms a complex with TRIM28 and DNA-dependent protein kinase (DNA-PK) t
Externí odkaz:
https://doaj.org/article/34b58a895ed248ba90fef65625529862
Autor:
Qiaozhu Zuo, Yongkang Yang, Yajing Lyu, Chen Yang, Chelsey Chen, Shaima Salman, Tina Yi-Ting Huang, Elizabeth E. Wicks, Walter Jackson, III, Emmanuel Datan, Wenxin Qin, Gregg L. Semenza
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112164- (2023)
Summary: Intratumoral hypoxia is a microenvironmental feature that promotes breast cancer progression and is associated with cancer mortality. Plexin B3 (PLXNB3) is highly expressed in estrogen receptor-negative breast cancer, but the underlying mech
Externí odkaz:
https://doaj.org/article/33aaf8ed82ef405fa617b1722f2239c3
Autor:
Sarah R Poll, Renan Martin, Elizabeth Wohler, Elizabeth S Partan, Elizabeth Walek, Shaima Salman, Daniel Groepper, Lisa Kratz, Mirlene Cernach, Reynaldo Jesus-Garcia, Chad Haldeman-Englert, Yoon Jae Choi, Carol D Morris, Bernard Cohen, Julie Hoover-Fong, David Valle, Gregg L Semenza, Nara L M Sobreira
Publikováno v:
PLoS Genetics, Vol 18, Iss 12, p e1010504 (2022)
Ollier disease (OD) and Maffucci Syndrome (MS) are rare disorders characterized by multiple enchondromas, commonly causing bone deformities, limb length discrepancies, and pathological fractures. MS is distinguished from OD by the development of vasc
Externí odkaz:
https://doaj.org/article/f07e766a88ed4dafa49601d362f73448
Autor:
Yu Qin, Aumreetam Dinabandhu, Xuan Cao, Jaron Castillo Sanchez, Kathleen Jee, Murilo Rodrigues, Chuanyu Guo, Jing Zhang, Jordan Vancel, Deepak Menon, Noore-Sabah Khan, Tao Ma, Stephany Y. Tzeng, Yassine Daoud, Jordan J. Green, Gregg L. Semenza, Silvia Montaner, Akrit Sodhi
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
Most patients with neovascular age-related macular degeneration (nvAMD), the leading cause of severe vision loss in elderly US citizens, respond inadequately to current therapies targeting a single angiogenic mediator, vascular endothelial growth fac
Externí odkaz:
https://doaj.org/article/37d58f59bf7947c89a0277022b678898
Autor:
Elizabeth E. Wicks, Gregg L. Semenza
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2 supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co-opt this homeostatic system to drive cancer progression. HIFs acti
Externí odkaz:
https://doaj.org/article/ea9b829e75b64d9098094fb70f374180
Autor:
Shaima Salman, David J. Meyers, Elizabeth E. Wicks, Sophia N. Lee, Emmanuel Datan, Aline M. Thomas, Nicole M. Anders, Yousang Hwang, Yajing Lyu, Yongkang Yang, Walter Jackson III, Dominic Dordai, Michelle A. Rudek, Gregg L. Semenza
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide and available therapies, including immunotherapies, are ineffective for many patients. HCC is characterized by intratumoral hypoxia, and increased expression of hypoxia-ind
Externí odkaz:
https://doaj.org/article/93de6172546f4b1dba403323cea12053
Autor:
Xinguo Jiang, Wen Tian, Dongeon Kim, Alexander S. McQuiston, Ryan Vinh, Stanley G. Rockson, Gregg L. Semenza, Mark R. Nicolls
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is
Externí odkaz:
https://doaj.org/article/bccb6e16fc2549ffa92a80ed208ca6fc