Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Gregg J. Johannes"'
Publikováno v:
International Journal of Medical Sciences, Vol 5, Iss 4, Pp 189-196 (2008)
The protective effects of iodine on breast cancer have been postulated from epidemiologic evidence and described in animal models. The molecular mechanisms responsible have not been identified but laboratory evidence suggests that iodine may inhibit
Externí odkaz:
https://doaj.org/article/e74cb0ad5e5a42db90b9c42693575681
Autor:
Stacey L Lehman, George J Cerniglia, Gregg J Johannes, Jiangbin Ye, Sandra Ryeom, Constantinos Koumenis
Publikováno v:
PLoS Genetics, Vol 11, Iss 6, p e1005212 (2015)
Multiple transcripts encode for the cell cycle inhibitor p21(Cip1). These transcripts produce identical proteins but differ in their 5' untranslated regions (UTRs). Although several stresses that induce p21 have been characterized, the mechanisms reg
Externí odkaz:
https://doaj.org/article/562337064b924c5ab48c02c35c3caf70
Autor:
Claudio Torres, Michael Bene, Christian Sell, Ashley Azar, Timothy Nacarelli, Gregg J. Johannes, Ibiyonu Lawrence, Justin Cohen
Publikováno v:
GeroScience. 40:193-199
Cellular senescence is a central component of the aging process. This cellular response has been found to be induced by multiple forms of molecular damage and senescent cells increase in number with age in all tissues examined to date. We have examin
Autor:
J. Steve Hou, Li Li, Praneeth Baratam, Michael Styler, William F. Morano, Marian Khalili, Gregg J. Johannes, Wilbur B. Bowne
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)
BMC Cancer
BMC Cancer
Background Gastrointestinal stromal tumor (GIST) is the most common primary mesenchymal neoplasm of the gastrointestinal tract. Mutations of KIT and platelet-derived growth factor receptor alpha have been well characterized in GISTs. Patients with KI
Autor:
Collin T. Stabler, Shimon Lecht, Peter I. Lelkes, Pimchanok Pimton, Edward S. Schulman, Gregg J. Johannes
Publikováno v:
Stem Cells and Development. 24:663-676
We investigated the effects of hypoxia on spontaneous (SP)- and activin A (AA)-induced definitive endoderm (DE) differentiation of mouse embryonic stem cells (mESCs) and their subsequent differentiation into distal pulmonary epithelial cells. SP diff
Publikováno v:
Mechanisms of Ageing and Development. 130:793-800
The insulin-like growth factor type 1 (IGF-I) plays an important role in neuronal physiology. Reduced IGF-I levels are observed during aging and this decrease may be important to age-related changes in the brain. We studied the effects of IGF-I on to
Publikováno v:
Journal of Biological Chemistry. 284:9039-9049
The alpha-globin poly(C)-binding proteins (alphaCPs) comprise an abundant and widely expressed set of K-homolog domain RNA-binding proteins. alphaCPs regulate the expression of a number of cellular and viral mRNAs at the levels of splicing, stability
Publikováno v:
International Journal of Medical Sciences
The protective effects of iodine on breast cancer have been postulated from epidemiologic evidence and described in animal models. The molecular mechanisms responsible have not been identified but laboratory evidence suggests that iodine may inhibit
Publikováno v:
RNA. 14:771-781
Translation is often repressed in cell lines that are exposed to hypoxic conditions (0.5% – 1.5% O2) but this repression requires prolonged exposure (> 16 h). We report here that prolonged exposure to hypoxia results in the depletion of glucose fro
Autor:
Antonio Russo, Sandra Cascio, Viviana Bartella, Gregg J. Johannes, Alessandra Auriemma, Antonio Giordano, Eva Surmacz
Publikováno v:
Oncogene. 27:540-547
We reported previously that the obesity hormone leptin is overexpressed in breast cancer biopsies. Here, we investigated molecular mechanisms involved in this process, focusing on conditions that are associated with obesity, that is, hyperinsulinemia