Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Gregg G. Gundersen"'
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract The apoptotic intrinsic pathway is initiated by perforation of the mitochondrial outer membrane by the effector pro-apoptotic proteins of the Bcl-2 family, Bax and Bak. Bax and Bak need to be activated, a process facilitated by the action of
Externí odkaz:
https://doaj.org/article/b42f32350b424ea5aeb70c5952862703
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
In this review, we discuss FHOD formins with a focus on recent studies that reveal a new role for them as critical links for nuclear mechanotransduction. The FHOD family in vertebrates comprises two structurally related proteins, FHOD1 and FHOD3. The
Externí odkaz:
https://doaj.org/article/337300f223e24f79b14c68ac6f1f871a
Autor:
José Wojnacki, Gonzalo Quassollo, Martín D. Bordenave, Nicolás Unsain, Gaby F. Martínez, Alan M. Szalai, Olivier Pertz, Gregg G. Gundersen, Francesca Bartolini, Fernando D. Stefani, Alfredo Cáceres, Mariano Bisbal
RhoA plays a crucial role in neuronal polarization, where its action restraining axon outgrowth has been thoroughly studied. We now report that RhoA has not only inhibitory but also a stimulatory effect on axon development depending on when and where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da46eee82bde32439f91a5e2ea6f6e3f
https://doi.org/10.1101/2023.04.17.537156
https://doi.org/10.1101/2023.04.17.537156
Autor:
Amir Vahabikashi, Suganya Sivagurunathan, Fiona Ann Sadsad Nicdao, Yu Long Han, Chan Young Park, Mark Kittisopikul, Xianrong Wong, Joseph R. Tran, Gregg G. Gundersen, Karen L. Reddy, G. W. Gant Luxton, Ming Guo, Jeffrey J. Fredberg, Yixian Zheng, Stephen A. Adam, Robert D. Goldman
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell mechanics through poorly understood mechanisms. Here we cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30db962e59a0d9fa90a517242523184b
https://doi.org/10.1073/pnas.2121816119
https://doi.org/10.1073/pnas.2121816119
Autor:
Ana J. García-Sáez, Gregg G. Gundersen, Aida Peña-Blanco, Dan Grozki, Reuven Stein, Ayelet R. Amsalem-Zafran, Howard J. Worman, Liora Lindenboim, Didier Hodzic, Christoph Borner
Publikováno v:
Cell Death Discovery, Vol 6, Iss 1, Pp 1-15 (2020)
Cell Death Discovery
Cell Death Discovery
The canonical function of Bcl-2 family proteins is to regulate mitochondrial membrane integrity. In response to apoptotic signals the multi-domain pro-apoptotic proteins Bax and Bak are activated and perforate the mitochondrial outer membrane by a me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd8095aef82589e6aac9a8eb66370a3
http://link.springer.com/article/10.1038/s41420-020-00327-6
http://link.springer.com/article/10.1038/s41420-020-00327-6
Autor:
Peter Meinke, Elisabetta Mattioli, Farhana Haque, Susumu Antoku, Marta Columbaro, Kees R Straatman, Howard J Worman, Gregg G Gundersen, Giovanna Lattanzi, Manfred Wehnert, Sue Shackleton
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004605 (2014)
Proteins of the nuclear envelope (NE) are associated with a range of inherited disorders, most commonly involving muscular dystrophy and cardiomyopathy, as exemplified by Emery-Dreifuss muscular dystrophy (EDMD). EDMD is both genetically and phenotyp
Externí odkaz:
https://doaj.org/article/4bca2c034f45441aae30b4fef24970eb
Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.
Autor:
Edward J Morris, Guilherme P F Nader, Nagendran Ramalingam, Francesca Bartolini, Gregg G Gundersen
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91568 (2014)
Selectively stabilized microtubules (MTs) form in the lamella of fibroblasts and contribute to cell migration. A Rho-mDia-EB1 pathway regulates the formation of stable MTs, yet how selective stabilization of MTs is achieved is unknown. Kinesin activi
Externí odkaz:
https://doaj.org/article/bca44b652204423fb58130cf4755e1b1
Autor:
Stephen A. Adam, Karen L. Reddy, Suganya Sivagurunathan, Chan Young Park, Robert D. Goldman, Yixian Zheng, Tran, Wong X, Jeffrey J. Fredberg, Gregg G. Gundersen, Amir Vahabikashi, Nicdao Fas, Ming Guo, Yu Long Han, Luxton Gg
The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell mechanics through poorly understood mechanisms. Here we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59d2872e5ecc95c3d1aa2059959c0ddd
https://doi.org/10.1101/2021.05.12.443683
https://doi.org/10.1101/2021.05.12.443683
Publikováno v:
Structure
The nuclear position in eukaryotic cells is controlled by a nucleo-cytoskeletal network, with important roles in cell differentiation, division and movement. Forces are transmitted through conserved linker of nucleoskeleton and cytoskeleton (LINC) co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73222238f9f1db703be4942d2bd50cc1
https://pubmed.ncbi.nlm.nih.gov/34087170
https://pubmed.ncbi.nlm.nih.gov/34087170
Publikováno v:
Seminars in Cell & Developmental Biology. 82:41-50
The positioning and movement of the nucleus has recently emerged as an important aspect of cell migration. Understanding of nuclear positioning and movement has reached an apogee in studies of fibroblast migration. Specific nuclear positioning and mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422828ad8c0f6652b13739db4d7e0827
https://doi.org/10.1016/j.semcdb.2017.11.006
https://doi.org/10.1016/j.semcdb.2017.11.006