Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Gregg E. Homanics"'
Autor:
Tracey D. Myers, Yizhi Li, Stefanie Taiclet, Paulina Cabada-Aguirre, Emily Kuti, Kaitlin McClure, Christopher Blanchard, Marta Wolosowicz, Gregg E. Homanics, Adam C. Straub, Stephen D. Meriney, Michael J. Palladino
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Triosephosphate isomerase deficiency (TPI Df) is a rare multisystem disorder with severe neuromuscular symptoms which arises exclusively from mutations within the TPI1 gene. Studies of TPI Df have been limited due to the absence of mammalian
Externí odkaz:
https://doaj.org/article/cadf9011a35d4760a00e26990a31124a
Autor:
Rachel C. Rice, Daniela V. Gil, Annalisa M. Baratta, Remy R. Frawley, Shirley Y. Hill, Sean P. Farris, Gregg E. Homanics
Publikováno v:
Neurobiology of Stress, Vol 29, Iss , Pp 100603- (2024)
Chronic stress and alcohol (ethanol) use are highly interrelated and can change an individual’s behavior through molecular adaptations that do not change the DNA sequence, but instead change gene expression. A recent wealth of research has found th
Externí odkaz:
https://doaj.org/article/0295550228b440a2b58a0af207e74b5f
Publikováno v:
Current Research in Neurobiology, Vol 3, Iss , Pp 100062- (2022)
Triosephosphate isomerase deficiency (TPI Df) is a rare, aggressive genetic disease that typically affects young children and currently has no established treatment. TPI Df is characterized by hemolytic anemia, progressive neuromuscular degeneration,
Externí odkaz:
https://doaj.org/article/79c5ac5e12ca420ca08778d42c2affb9
Autor:
Megan K. Mulligan, Timothy Abreo, Sarah M. Neuner, Cory Parks, Christine E. Watkins, M. Trevor Houseal, Thomas M. Shapaker, Michael Hook, Haiyan Tan, Xusheng Wang, Jesse Ingels, Junmin Peng, Lu Lu, Catherine C. Kaczorowski, Camron D. Bryant, Gregg E. Homanics, Robert W. Williams
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
GABA type-A (GABA-A) receptors containing the α2 subunit (GABRA2) are expressed in most brain regions and are critical in modulating inhibitory synaptic function. Genetic variation at the GABRA2 locus has been implicated in epilepsy, affective and p
Externí odkaz:
https://doaj.org/article/6a8d1268bcf34cf8a5aabfe4fc41124e
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
Stress-related psychiatric disorders such as major depression are strongly associated with alcohol abuse and alcohol use disorder. Recently, many epidemiological and preclinical studies suggest that chronic stress prior to conception has cross-genera
Externí odkaz:
https://doaj.org/article/8a1f4f16191b4491a76d599c692ddb4b
Autor:
Richa S. Rathod, Carolyn Ferguson, Amit Seth, Annalisa M. Baratta, Sonja L. Plasil, Gregg E. Homanics
Publikováno v:
Brain Sciences, Vol 10, Iss 9, p 658 (2020)
We and others previously reported that paternal preconception chronic ethanol exposure leads to molecular, physiological, and behavioral changes in offspring including reduced ethanol consumption and preference relative to controls. The goal of the p
Externí odkaz:
https://doaj.org/article/0073012d63544706a2f104cd502e5058
Autor:
Gregory R. Rompala, Anais Mounier, Cody M. Wolfe, Qishan Lin, Iliya Lefterov, Gregg E. Homanics
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
While the risks of maternal alcohol abuse during pregnancy are well-established, several preclinical studies suggest that chronic preconception alcohol consumption by either parent may also have significance consequences for offspring health and deve
Externí odkaz:
https://doaj.org/article/ff1ffea0074d4d349999668fc76cdfd8
Autor:
Christopher P. Pratt, Dika A. Kuljis, Gregg E. Homanics, Jianjun He, Dmytro Kolodieznyi, Srikanth Dudem, Mark A. Hollywood, Alison L. Barth, Marcel P. Bruchez
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
BK channels are critical regulators of neuronal activity, controlling firing, neurotransmitter release, cerebellar function, and BK channel mutations have been linked to seizure disorders. Modulation of BK channel gating is well characterized, regula
Externí odkaz:
https://doaj.org/article/d3f66848f4d14d3095304eaacaee8b1c
Autor:
Julie M. Cramer, Mark W. Zimmerman, Tim Thompson, Gregg E. Homanics, John S. Lazo, Eric Lagasse
Publikováno v:
Stem Cell Research, Vol 13, Iss 1, Pp 164-171 (2014)
The PTP4A3 gene is highly expressed in human colon cancer and often associates with enhanced metastatic potential. Genetic disruption of the mouse Ptp4a3 gene reduces the frequency of colon tumor formation in mice treated in a colitis-associated canc
Externí odkaz:
https://doaj.org/article/6706bdf6017147a0bb784ccec4764239
Autor:
Annalisa M. Baratta, Regina A. Mangieri, Heather C. Aziz, Marcelo F. Lopez, Sean P. Farris, Gregg E. Homanics
Publikováno v:
Alcohol
Extracellular vesicles (EVs) are important players in normal biological function and disease pathogenesis. Of the many biomolecules packaged into EVs, coding and noncoding RNA transcripts are of particular interest for their ability to significantly