Výsledky vyhledávání - "Gregg D, Cappon"

The Postnatal Resolution of Developmental Toxicity Induced by Pharmacological Diacylglycerol Acyltransferase 2 (DGAT2) Inhibition During Gestation in Rats

Autor: Natasha R Catlin, Christopher J Bowman, Sarah N Campion, Elise M Lewis, William S Nowland, Christine Stethem, Gregg D Cappon

Publikováno v: Toxicological Sciences. 189:225-236

Ervogastat (PF-06865571) is a small molecule diacylglycerol acyltransferase 2 (DGAT2) inhibitor being developed for the oral treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis. DGAT2 is a key enzyme in triglyceride synthesis in tiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8406685f49264eb55b560fab52e2d7d6
https://doi.org/10.1093/toxsci/kfac077

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Regulatory Experience Assessing the Carcinogenic Potential of a Monoclonal Antibody Inhibiting PCSK9, Bococizumab, Including a 2-Year Carcinogenicity Study in Rats

Autor: Bernard S. Buetow, Gregg D Cappon, Laura M. Aschenbrenner, Lawrence Updyke, Vince R. Torti, Mark Evans, Shana R. Dalton, Steven Bailey, Christopher J. Bowman

Publikováno v: International Journal of Toxicology. 41:389-401

Bococizumab is an anti-PCSK9 monoclonal antibody that was intended for the treatment of hypercholesterolemia. After reviewing the 6-month rat toxicity study data, in which there was a low spontaneous tumor incidence, unrelated to bococizumab administ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7d16867d57951ce3092b8f8d26e92f
https://doi.org/10.1177/10915818221106397

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Maternal immunization with Group B Streptococcus six‐valent polysaccharide conjugate vaccine supported by lack of toxicity in rat and rabbit fertility and developmental toxicity studies

Autor: Annaliesa S. Anderson, William S. Nowland, Natasha R. Catlin, Gregg D. Cappon, Scott Engel, Ingrid L. Scully, Christopher J. Bowman, Cynthia M. Rohde, Sandra M. Buitrago

Publikováno v: Birth Defects Research. 113:1343-1356

A maternal Group B Streptococcus (GBS) six-valent polysaccharide conjugate vaccine (GBS6) is being developed to protect neonates and infants up to 3 months of age through passive transfer of antibodies from the mother to the infant. Fertility and dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88aff61b35ca63e2d5d7ed89a832d473
https://doi.org/10.1002/bdr2.1953

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Juvenile toxicity study of PF-07256472/recifercept, a recombinant human soluble fibroblast growth factor receptor 3, in 2-3-month-old cynomolgus monkeys

Autor: Sarah N. Campion, Christopher J. Bowman, Antje Fuchs, David Karanian, Payal Rana, Gregg D. Cappon

Publikováno v: Birth defects researchREFERENCES.

Achondroplasia is an autosomal disorder caused by point mutation in the gene encoding fibroblast growth factor receptor 3 (FGFR3) and resulting in gain of function. Recifercept is a potential disease modifying treatment for achondroplasia and functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3261062f97b1f60d4f7ae6a010cfedae
https://pubmed.ncbi.nlm.nih.gov/36367445

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Inhibition of Acetyl-CoA Carboxylase Causes Malformations in Rats and Rabbits: Comparison of Mammalian Findings and Alternative Assays

Autor: William S. Nowland, Steven W. Kumpf, Trenton T. Ross, Christopher J. Bowman, Gregg D. Cappon, Donald S Stedman, Scott D Davenport, William P. Esler, Christine Stethem, Natasha R. Catlin, Elise M. Lewis, Sarah N. Campion

Publikováno v: Toxicological Sciences. 179:183-194

Acetyl-CoA carboxylase (ACC) is an enzyme within the de novo lipogenesis (DNL) pathway and plays a role in regulating lipid metabolism. Pharmacologic ACC inhibition has been an area of interest for multiple potential indications including oncology, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6d9eb6a77626c055c46264ceba500b
https://doi.org/10.1093/toxsci/kfaa169

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Maternal immunization with Group B Streptococcus six-valent polysaccharide conjugate vaccine supported by lack of toxicity in rat and rabbit fertility and developmental toxicity studies

Autor: Natasha R, Catlin, Gregg D, Cappon, Scott, Engel, Cynthia, Rohde, William S, Nowland, Sandra, Buitrago, Ingrid, Scully, Annaliesa S, Anderson, Christopher J, Bowman

Publikováno v: Birth defects researchREFERENCES. 113(19)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58c404b4dcfa9c764517e182d114a547
https://pubmed.ncbi.nlm.nih.gov/34516044

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Lack of effects on female fertility and prenatal and postnatal offspring development in rats with BNT162b2, a mRNA-based COVID-19 vaccine

Autor: Sarah N. Campion, Claudia Lindemann, Gregg D. Cappon, Christopher J. Bowman, Rani S. Sellers, Jan Diekmann, Cynthia M. Rohde, Marie Bouressam, Mark Cutler, Natasha R. Catlin

Publikováno v: Reproductive Toxicology (Elmsford, N.y.)

BNT162b2 is a vaccine developed to prevent coronavirus disease 2019 (COVID-19). BNT162b2 is a lipid nanoparticle formulated nucleoside-modified messenger RNA (mRNA) encoding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3395824bfd2b8be7cdacd6a416a8a3e7
https://pubmed.ncbi.nlm.nih.gov/34058573

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