Výsledky vyhledávání - "Gregg A. Timony"

Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity

Autor: Srinivas R, Kasibhatla, Kevin, Hong, Marco A, Biamonte, David J, Busch, Patricia L, Karjian, John L, Sensintaffar, Adeela, Kamal, Rachel E, Lough, John, Brekken, Karen, Lundgren, Roy, Grecko, Gregg A, Timony, Yingqing, Ran, Robert, Mansfield, Lawrence C, Fritz, Edgar, Ulm, Francis J, Burrows, Marcus F, Boehm

Publikováno v: Journal of medicinal chemistry. 50(12)

Heat shock protein 90 (Hsp90) is a molecular chaperone protein implicated in stabilizing the conformation and maintaining the function of many cell-signaling proteins. Many oncogenic proteins are more dependent on Hsp90 in maintaining their conformat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d4b2feee8ee425cef56bd83ad21acf6
https://pubmed.ncbi.nlm.nih.gov/17488003

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Orally active purine-based inhibitors of the heat shock protein 90

Autor: Marco A. Biamonte, Jiandong Shi, Kevin Hong, David C. Hurst, Lin Zhang, Junhua Fan, David J. Busch, Patricia L. Karjian, Angelica A. Maldonado, John L. Sensintaffar, Yong-Ching Yang, Adeela Kamal, Rachel E. Lough, Karen Lundgren, Francis J. Burrows, Gregg A. Timony, Marcus F. Boehm, Srinivas R. Kasibhatla

Publikováno v: Journal of medicinal chemistry. 49(2)

Orally active Hsp90 inhibitors are of interest as potential chemotherapeutic agents. Recently, fully synthetic 8-benzyladenines and 8-sulfanyladenines such as 4 were disclosed as Hsp90 inhibitors, but these compounds are not water soluble and consequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2da73f004611c3197e278f58c8174aa
https://pubmed.ncbi.nlm.nih.gov/16420067

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The Disposition of Ethiofos (WR-2721) in the Isolated Perfused Rat Liver

Autor: Lawrence Fleckenstein, Donald J. Mangold, Gregg A. Timony, Thomas G. Brewer, Richard S. Geary, Michael D. Coleman

Publikováno v: Radiation Research. 117:334

We have investigated the disposition of ethiofos (20 mg, 4 microCi (14C)ethiofos) in the isolated perfused rat liver preparation to determine the hepatic contribution to the poor oral bioavailability of the drug. Ethiofos clearance (10.6 +/- 3.3 ml h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3862e240bb22decd5dbce4ee5e6e1ab
https://doi.org/10.2307/3577334

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