Výsledky vyhledávání - "Gregg, Crumley"

Phenylarsine oxide as a redox modulator of transient receptor potential vanilloid type 1 channel function

Autor: Victor I. Ilyin, Kevin P. Carlin, Gregg Crumley, Aniket Patel, Gang Wu

Publikováno v: Journal of Neuroscience Research. 93:309-320

Transient receptor potential vanilloid type 1 (TRPV1) channels are capable of detecting and integrating noxious stimuli and play an important role in nociceptor activation and sensitization. It has been demonstrated that oxidizing agents are capable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a08795050ae3fa455122a9b0879e1c1f
https://doi.org/10.1002/jnr.23479

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State-Dependent Compound Inhibition of Nav1.2 Sodium Channels Using the FLIPR Vm Dye: On-Target and Off-Target Effects of Diverse Pharmacological Agents

Autor: Richard M. Woodward, Victor I. Ilyin, Kenneth J. Valenzano, Gregg Crumley, Shakira Olanrewaju, Elfrida R. Benjamin, Farhana Pruthi, Elena Kutlina

Publikováno v: SLAS Discovery. 11:29-39

Voltage-gated sodium channels (NaChs) are relevant targets for pain, epilepsy, and a variety of neurological and cardiac disorders. Traditionally, it has been difficult to develop structure-activity relationships for NaCh inhibitors due to rapid chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93f43453695c07442fc4479f93b0e3a
https://doi.org/10.1177/1087057105280918

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DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat

Autor: Kenneth J. Valenzano, Scott Nolan, Yakov Rotshteyn, Sam Victory, Shen Shan, Kevin Christopher Brogle, Donald J. Kyle, Ellen Davies, Jincheng Huang, Nezima Allie, Gregg Crumley, Wendy S. Miller, Zhengming Chen

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 310:793-799

Mu opioid receptors are expressed throughout the central and peripheral nervous systems. Peripheral inflammation leads to an increase in mu receptor present on the peripheral terminals of primary sensory neurons. Activation of peripheral mu receptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7485d49ff5391bf2671e60c5a7ee873
https://doi.org/10.1124/jpet.103.063560

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DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties

Autor: Kenneth J, Valenzano, Wendy, Miller, Zhengming, Chen, Shen, Shan, Gregg, Crumley, Sam F, Victory, Ellen, Davies, Jin-Cheng, Huang, Nezima, Allie, Scott J, Nolan, Yakov, Rotshteyn, Donald J, Kyle, Kevin, Broglé

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 310:783-792

Mu opioid receptors are present throughout the central and peripheral nervous systems. Peripheral inflammation causes an increase in mu receptor levels on peripheral terminals of primary afferent neurons. Recent studies indicate that activation of pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbf73bf642af1980003ca5b87df0e6f
https://doi.org/10.1124/jpet.103.063313

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Phenylarsine oxide as a redox modulator of transient receptor potential vanilloid type 1 channel function

Autor: Kevin P, Carlin, Gang, Wu, Aniket, Patel, Gregg, Crumley, Victor I, Ilyin

Publikováno v: Journal of neuroscience research. 93(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::695226e5f1d27cd71fba709097af051f
https://pubmed.ncbi.nlm.nih.gov/25250537

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Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

Autor: Michael Jaye, Ivan Dikic, Gregg Crumley, Dalia Pinchasi, John E. Ladbury, Jiaoti Huang, T Spivak-Kroizman, Mark A. Lemmon, Joseph Schlessinger, Irit Lax

Publikováno v: Cell. 79:1015-1024

Heparin is required for fibroblast growth factor (FGF) stimulation of biological responses. Using isothermal titration calorimetry, we show that acidic FGF (aFGF) forms a 1:1 complex with the soluble extracellular domain of FGF receptor (FGFR). Hepar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387cffca76addc1e87cfcc362a393fd8
https://doi.org/10.1016/0092-8674(94)90032-9

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Ligand-induced transphosphorylation between different FGF receptors

Autor: Francoise Bellot, Gregg Crumley, J. M. Kaplow, Michael Jaye, Craig A. Dionne, Joseph Schlessinger

Publikováno v: The EMBO Journal. 10:2849-2854

Recent evidence shows that different fibroblast growth factors (FGF) bind with similar high affinities to two FGF receptors (FGFR) called flg and bek. In order to explore the mechanism of FGFR tyrosine autophosphorylation, we have generated cell line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fcbf4171bf15279f124bae326af2ddf
https://doi.org/10.1002/j.1460-2075.1991.tb07834.x

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The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon

Autor: Craig A. Dionne, Gregg Crumley, Michael C. Jaye

Publikováno v: Biochemical and Biophysical Research Communications. 171:7-13

We have isolated two cDNA clones encoding human acidic fibroblast growth factor (aFGF) which represent the utilization of alternative upstream exons in aFGF mRNA. Isolation and sequence analysis of genomic clones spanning the first coding exon and ea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed6d85685257509d3fb6794034ce581
https://doi.org/10.1016/0006-291x(90)91348-v

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A miniaturized column chromatography method for measuring receptor-mediated inositol phosphate accumulation

Autor: Kenneth J. Valenzano, Mohamed Hachicha, Elfrida R. Benjamin, Dimitris N. Xanthos, Sarah L. Haftl, Gregg Crumley

Publikováno v: Journal of biomolecular screening. 9(4)

Inositol phosphates (IPs), such as 1,4,5-inositol-trisphosphate (IP(3)), comprise a ubiquitous intracellular signaling cascade initiated in response to G protein-coupled receptor-mediated activation of phospholipase C. Classical methods for measuring

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a2817cf45d09941b038a3b12089b42
https://pubmed.ncbi.nlm.nih.gov/15191651

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BEK, a receptor for multiple members of the fibroblast growth factor (FGF) family, maps to human chromosome 10q25.3→q26

Autor: C. A. Dionne, Gregg Crumley, William S. Modi, Stephen J. O'Brien, J. Schlessinger, Michael C. Jaye

Publikováno v: Cytogenetic and Genome Research. 60:34-36

The gene for the fibroblast growth factor receptor BEK was assigned to human chromosome 10 by applying polymerase chain reaction techniques to DNAs from a panel of human × rodent somatic cell hybrids. The gene was further localized to 10q25.3→q26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40191407e9dd57d3d6f3ef37ecfcadab
https://doi.org/10.1159/000133290

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