Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Gregers R Andersen"'
Autor:
Dennis V Pedersen, Martin Nors Pedersen, Sofia MM Mazarakis, Yong Wang, Kresten Lindorff-Larsen, Lise Arleth, Gregers R Andersen
Publikováno v:
eLife, Vol 10 (2021)
Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the oligomerization state, but whether properdin oligomers are rigid and how their structure l
Externí odkaz:
https://doaj.org/article/509b50692e87409e8d17e853f49751c6
Autor:
Liz Stevenson, Erik Laursen, Graeme J Cowan, Betty Bandoh, Lea Barfod, David R Cavanagh, Gregers R Andersen, Lars Hviid
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1005022 (2015)
Rosetting, the adhesion of Plasmodium falciparum-infected erythrocytes to uninfected erythrocytes, involves clonal variants of the parasite protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) and soluble serum factors. While rosetting is a
Externí odkaz:
https://doaj.org/article/4057f8d9f5d74df5be812adaffa964e0
Autor:
Kristian Juul-Madsen, Peter Parbo, Rola Ismail, Peter L. Ovesen, Vanessa Schmidt, Lasse S. Madsen, Jacob Thyrsted, Sarah Gierl, Mihaela Breum, Agnete Larsen, Morten N. Andersen, Marina Romero-Ramos, Christian K. Holm, Gregers R. Andersen, Huaying Zhao, Peter Schuck, Jens V. Nygaard, Duncan S. Sutherland, Simon F. Eskildsen, Thomas E. Willnow, David J. Brooks, Thomas Vorup-Jensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The peripheral immune system is important in neurodegenerative diseases, both in protecting and inflaming the brain, but the underlying mechanisms remain elusive. Alzheimer’s Disease is commonly preceded by a prodromal period. Here, we rep
Externí odkaz:
https://doaj.org/article/81c39ad41509420b82e48e637c1da445
Autor:
Katharina Braunger, Jiyoon Ahn, Matthijs M. Jore, Steven Johnson, Terence T. L. Tang, Dennis V. Pedersen, Gregers R. Andersen, Susan M. Lea
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Properdin is the only known positive regulator of the human complement system, stabilising the convertase C3 in the alternative pathway of complement activation. Here, the authors report the identification and characterisation of a species-specific p
Externí odkaz:
https://doaj.org/article/5b1add1310284327ac11638749c24bcd
Autor:
Nick S. Laursen, Dennis V. Pedersen, Heidi Gytz, Alessandra Zarantonello, Jens Magnus Bernth Jensen, Annette G. Hansen, Steffen Thiel, Gregers R. Andersen
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies. We describe the development and in vitro charact
Externí odkaz:
https://doaj.org/article/f5719bd1f44141fd8a64312c7a8685db
Autor:
Frederic Jabs, Melanie Plum, Nick S. Laursen, Rasmus K. Jensen, Brian Mølgaard, Michaela Miehe, Marco Mandolesi, Michèle M. Rauber, Wolfgang Pfützner, Thilo Jakob, Christian Möbs, Gregers R. Andersen, Edzard Spillner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
IgE is linked to allergic diseases and there is a great interest in developing anti-IgE therapeutics. Here the authors characterize the binding of human IgE Fc to a single domain antibody (sdab) and show that the sdab induces a closed conformation, w
Externí odkaz:
https://doaj.org/article/100e1c2461b14a39be4cdf8caf230db8
Autor:
Vivien R. Schack, Morten K. Herlin, Henrik Pedersen, J. Magnus Bernth Jensen, Mia Færch, Bettina Bundgaard, Rasmus K. Jensen, Uffe B. Jensen, Rikke Christensen, Gregers R. Andersen, Steffen Thiel, Per Höllsberg
Publikováno v:
Schack, V R, Herlin, M K, Pedersen, H, Jensen, J M B, Faerch, M, Bundgaard, B, Jensen, R K, Jensen, U B, Christensen, R, Andersen, G R, Thiel, S & Höllsberg, P 2022, ' Novel homozygous CD46 variant with C-isoform expression affects C3b inactivation in atypical hemolytic uremic syndrome ', European Journal of Immunology, vol. 52, no. 10, pp. 1610-1619 . https://doi.org/10.1002/eji.202249838
Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy that may lead to organ failure. Dysregulation of the complement system can cause aHUS, and various disease-related variants in the complement regulatory protein CD46 are descri
Autor:
Melanie Plum, Luna Tjerrild, Tim Raiber, Frank Bantleon, Sara Bantleon, Michaela Miehe, Frederic Jabs, Henning Seismann, Christian Möbs, Wolfgang Pfützner, Thilo Jakob, Gregers R. Andersen, Edzard Spillner
Publikováno v:
Allergy. 78:121-130
Autor:
Dennis V. Pedersen, Trine A. F. Gadeberg, Caroline Thomas, Yong Wang, Nicolas Joram, Rasmus K. Jensen, Sofia M. M. Mazarakis, Margot Revel, Carine El Sissy, Steen V. Petersen, Kresten Lindorff-Larsen, Steffen Thiel, Nick S. Laursen, Véronique Fremeaux-Bacchi, Gregers R. Andersen
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structure
Externí odkaz:
https://doaj.org/article/ac896c2448754a3fb20a2396a833fbe7
The dynamics of hinge flexibility in receptor bound immunoglobulin E revealed by electron microscopy
Immunoglobulin E is a mammal specific antibody isotype supporting the immune response against parasites and venoms, but also a driver of allergic responses. Structural and biophysical studies have defined the conformation of the IgE Fc fragment bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebee8b21eda9f0049dabbbd81a84e2dd
https://doi.org/10.1101/2023.02.17.528943
https://doi.org/10.1101/2023.02.17.528943