Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Gregers J. Gram"'
Autor:
Ria Lassaunière, Charlotta Polacek, Gregers J. Gram, Anders Frische, Jeanette Linnea Tingstedt, Maren Krüger, Brigitte G. Dorner, Anthony Cook, Renita Brown, Tatyana Orekov, Tammy Putmon-Taylor, Tracey-Ann Campbell, Jack Greenhouse, Laurent Pessaint, Hanne Andersen, Mark G. Lewis, Anders Fomsgaard
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-13 (2021)
Abstract New generation plasmid DNA vaccines may be a safe, fast and simple emergency vaccine platform for preparedness against emerging viral pathogens. Applying platform optimization strategies, we tested the pre-clinical immunogenicity and protect
Externí odkaz:
https://doaj.org/article/eb1cc7b9d0d241ab959968f66a8f49b5
Autor:
Peter Aaby, Marie Borggren, Betina S Andresen, Joakim Esbjörnsson, Anders Fomsgaard, Gregers J Gram, Lasse Vinner, Eva Maria Fenyö, Henrik Kloverpris, Birgitta G Holmgren, Julie L Hentze, Ingrid Karlsson, Zacarias da Silva, Kristoffer Jarlov Jensen
Publikováno v:
APMIS. 119:487-497
For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e12ea40c9f4988fb39b1c279fff8218
https://doi.org/10.1111/j.1600-0463.2011.02763.x
https://doi.org/10.1111/j.1600-0463.2011.02763.x
Autor:
Sigvard Olofsson, A. Bolmstedt, Gregers J. Gram, M. Biller, Kristian Schønning, John-Erik Stig Hansen
Publikováno v:
APMIS. 110:123-131
Several functions have been assigned to the extensive glycosylation of HIV-1 envelope glycoprotein gp120, especially immune escape mechanisms, but the intramolecular interactions between gp120 and its carbohydrate complement are not well understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccaf799564cc284fe0fbb85f0c49455b
https://doi.org/10.1034/j.1600-0463.2002.100202.x
https://doi.org/10.1034/j.1600-0463.2002.100202.x
Publikováno v:
APMIS. 108:38-44
Retroviral vectors constitute the most efficient system to deliver and integrate foreign genes into mammalian cells. One of the most laborious routine assays in the application of retroviral-mediated gene transfer is the determination of viral titers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234d1f79d1edd1e6172fc318111bca54
https://doi.org/10.1034/j.1600-0463.2000.d01-3.x
https://doi.org/10.1034/j.1600-0463.2000.d01-3.x
Publikováno v:
Cytometry. 37:284-290
Background: A stream-in-air cell sorter enables rapid sorting to a high purity, but it is not well suited for sorting of infectious material due to the risk of airborne spread to the surroundings. Methods: A FACS Vantage cell sorter was modified for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b899e6b27ddcac4e08732def0a204e9
https://doi.org/10.1002/(sici)1097-0320(19991201)37:4<284::aid-cyto5>3.0.co
https://doi.org/10.1002/(sici)1097-0320(19991201)37:4<284::aid-cyto5>3.0.co
Autor:
Gregers J. Gram, Peter Buhl Jensen, Mette Due Theilade, Maurizio Cianfriglia, John-Erik Stig Hansen, Mikael Rørth
Publikováno v:
APMIS. 107:851-858
Multidrug resistance (MDR) remains a major problem in the successful treatment of small cell lung cancer (SCLC). New treatment strategies are needed, such as gene therapy specifically targeting the MDR cells in the tumor. Retroviral LacZ gene-contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8409e66bc47b232bcc00c62052ea0c9
https://doi.org/10.1111/j.1699-0463.1999.tb01482.x
https://doi.org/10.1111/j.1699-0463.1999.tb01482.x
Publikováno v:
Journal of Hematotherapy. 7:333-341
We have constructed a functional murine leukemia virus (MLV)-derived retroviral vector transducing two genes encoding the autofluorescent humanized green fluorescent protein (hGFP) and neomycin phosphotransferase (Neo). This was done to determine whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80128604a3c3fffc38da35c386fab001
https://doi.org/10.1089/scd.1.1998.7.333
https://doi.org/10.1089/scd.1.1998.7.333
Autor:
Susanne Dam Nielsen, Gregers J. Gram, Maxwell Sehested, Peter Buhl Jensen, John-Erik Stig Hansen, Jens Ole Nielsen, Anders Sørensen, Mikael Rørth
Publikováno v:
Europe PubMed Central
Direct gene transfer to solid tissues or metastatic cancer cells requires vectors capable of in vivo transduction to specific cells. The predominant retroviral vectors of murine origin are inactivated by human complement, which precludes their use in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dab584f3aca69b0298878ea05b995aa
https://doi.org/10.1111/j.1699-0463.1997.tb05077.x
https://doi.org/10.1111/j.1699-0463.1997.tb05077.x
Autor:
Susanne Dam Nielsen, Ole Søgaard Lund, J. O. Nielsen, Ole Lund, Kristian Schønning, Gregers J. Gram, Erik Mosekilde, John-Erik Stig Hansen
Publikováno v:
Bulletin of Mathematical Biology. 59:725-745
This paper presents a mathematical analysis of the criteria for gene therapy of T helper cells to have a clinical effect on HIV infection. The analysis indicates that for such a therapy to be successful, it must protect the transduced cells against H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f4ddfa0645cebbec34c9a6fd0684af8
https://doi.org/10.1007/bf02458427
https://doi.org/10.1007/bf02458427
Autor:
Sigvard Olofsson, Anders Bolmstedt, John-Erik Stig Hansen, Anna Hemming, Gregers J. Gram, A. Ricksten, B. Losman
Publikováno v:
Archives of Virology. 141:2139-2151
We have constructed a mutated infectious HIV variant lacking the signals for addition of three N-linked glycans situated in the V4, C4 and V5 regions of HIV gp120. When comparing mutated virus with wildtype virus we found essentially no differences i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410b01c43169ca2e25a451049dfb2d31
https://doi.org/10.1007/bf01718221
https://doi.org/10.1007/bf01718221