Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Gregers G. Hermann"'
Autor:
Iwan W. Schie, Fabian Placzek, Florian Knorr, Eliana Cordero, Lara M. Wurster, Gregers G. Hermann, Karin Mogensen, Thomas Hasselager, Wolfgang Drexler, Jürgen Popp, Rainer A. Leitgeb
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The combination of manifold optical imaging modalities resulting in multimodal optical systems allows to discover a larger number of biomarkers than using a single modality. The goal of multimodal imaging systems is to increase the diagnosti
Externí odkaz:
https://doaj.org/article/a62849cb59a744e9b990f15d86b86221
Autor:
Sia Viborg Lindskrog, Frederik Prip, Philippe Lamy, Ann Taber, Clarice S. Groeneveld, Karin Birkenkamp-Demtröder, Jørgen Bjerggaard Jensen, Trine Strandgaard, Iver Nordentoft, Emil Christensen, Mateo Sokac, Nicolai J. Birkbak, Lasse Maretty, Gregers G. Hermann, Astrid C. Petersen, Veronika Weyerer, Marc-Oliver Grimm, Marcus Horstmann, Gottfrid Sjödahl, Mattias Höglund, Torben Steiniche, Karin Mogensen, Aurélien de Reyniès, Roman Nawroth, Brian Jordan, Xiaoqi Lin, Dejan Dragicevic, Douglas G. Ward, Anshita Goel, Carolyn D. Hurst, Jay D. Raman, Joshua I. Warrick, Ulrika Segersten, Danijel Sikic, Kim E. M. van Kessel, Tobias Maurer, Joshua J. Meeks, David J. DeGraff, Richard T. Bryan, Margaret A. Knowles, Tatjana Simic, Arndt Hartmann, Ellen C. Zwarthoff, Per-Uno Malmström, Núria Malats, Francisco X. Real, Lars Dyrskjøt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Multiple molecular profiling methods are required to study urothelial non-muscle-invasive bladder cancer (NMIBC) due to its heterogeneity. Here the authors integrate multi-omics data of 834 NMIBC patients, identifying a molecular subgroup associated
Externí odkaz:
https://doaj.org/article/25de5d15c38f4468b633c9e4bdca4e8d
Autor:
Ellen C. Zwarthoff, Torben F. Ørntoft, Per-Uno Malmström, Núria Malats, Francisco X. Real, Joost L. Boormans, Kerstin Junker, Jørgen B. Jensen, Astrid C. Petersen, Niels Harving, Arndt Hartmann, Karin Mogensen, Gregers G. Hermann, Marc-Oliver Grimm, Marcus Horstmann, Tatjana Simic, Tobias Maurer, Bastian Keck, Ulrika Segersten, Willemien Beukers, Naeromy Y.C. Welvaart, Ferran Algaba, Lars Dyrskjøt, Kirstin A. van der Keur, Kim E.M. van Kessel
Supplementary figure S8. Progression-free survival curve in patients with EAU high risk tumors of a combination of FGFR3 and GATA2 status. Blue: good status (hypomethylated GATA2 and mutated FGFR3), green; moderate status (either hypermethylated GATA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839789f93543029f8348f73e9a2eb8bb
https://doi.org/10.1158/1078-0432.22464569
https://doi.org/10.1158/1078-0432.22464569
Autor:
Ellen C. Zwarthoff, Torben F. Ørntoft, Per-Uno Malmström, Núria Malats, Francisco X. Real, Joost L. Boormans, Kerstin Junker, Jørgen B. Jensen, Astrid C. Petersen, Niels Harving, Arndt Hartmann, Karin Mogensen, Gregers G. Hermann, Marc-Oliver Grimm, Marcus Horstmann, Tatjana Simic, Tobias Maurer, Bastian Keck, Ulrika Segersten, Willemien Beukers, Naeromy Y.C. Welvaart, Ferran Algaba, Lars Dyrskjøt, Kirstin A. van der Keur, Kim E.M. van Kessel
Supplementary Table S2. Cut-offs for dichotomization of the methylation marker results were chosen based on the desired sensitivity-specificity trade-off for progression to MIBC as visualized by the receiver-operating characteristic curve (ROC curve)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30adab21fbd59d86268d22a20ae141de
https://doi.org/10.1158/1078-0432.22464563.v1
https://doi.org/10.1158/1078-0432.22464563.v1
Autor:
Ellen C. Zwarthoff, Torben F. Ørntoft, Per-Uno Malmström, Núria Malats, Francisco X. Real, Joost L. Boormans, Kerstin Junker, Jørgen B. Jensen, Astrid C. Petersen, Niels Harving, Arndt Hartmann, Karin Mogensen, Gregers G. Hermann, Marc-Oliver Grimm, Marcus Horstmann, Tatjana Simic, Tobias Maurer, Bastian Keck, Ulrika Segersten, Willemien Beukers, Naeromy Y.C. Welvaart, Ferran Algaba, Lars Dyrskjøt, Kirstin A. van der Keur, Kim E.M. van Kessel
Purpose: The European Association of Urology (EAU) guidelines for non–muscle-invasive bladder cancer (NMIBC) recommend risk stratification based on clinicopathologic parameters. Our aim was to investigate the added value of biomarkers to improve ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff6f823fded43852feeeb7d38f3e444
https://doi.org/10.1158/1078-0432.c.6525746
https://doi.org/10.1158/1078-0432.c.6525746
Autor:
Frederik Prip, Philippe Lamy, Iver Nordentoft, Sia Viborg Lindskrog, Trine Strandgaard, Karin Birkenkamp-Demtröder, Gregers G. Hermann, Astrid C. Petersen, Veronika Bahlinger, Marc-Oliver Grimm, Marcus Horstmann, Karin Mogensen, Roman Nawroth, Ulrika Segersten, Danijel Sikic, Kim E. M van Kessel, Tobias Maurer, Tatjana Simic, Arndt Hartmann, Ellen C. C. Zwarthoff, Per-Uno Malmström, Torben Steiniche, Jørgen Bjerggaard Jensen, Núria Malats, Francisco X. Real, Lars Dyrskjøt
Publikováno v:
Cancer Research. 83:6075-6075
Background: The genomic landscape of cancer is complex and includes mutations and copy number alterations (CNAs) that affect several cancer related pathways and drive tumor evolution. Non-muscle-invasive bladder cancers (NMIBC) are largely orphan for
Autor:
Bhavna Oza, Tim Eisen, Eleni Frangou, Grant D. Stewart, Axel Bex, Alastair W.S. Ritchie, Rick Kaplan, Benjamin Smith, Ian D. Davis, Martin R. Stockler, Laurence Albiges, Bernard Escudier, James Larkin, Steven Joniau, Barry Hancock, Gregers G. Hermann, Joaquim Bellmunt, Mahesh K.B. Parmar, Patrick Royston, Angela Meade
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 40(16)
PURPOSE The 2003 Leibovich score guides prognostication and selection to adjuvant clinical trials for patients with locally advanced renal cell carcinoma (RCC) after nephrectomy. We provide a robust external validation of the 2003 Leibovich score usi
Autor:
Mikael T. Erkkilä, Lara M. Wurster, Gerardo González-Cerdas, Florian Knorr, Peter Andersen, Hans Zappe, Iwan W. Schie, Thomas Hasselager, Karin Mogensen, Eliana Cordero Bautista, Rainer A. Leitgeb, Fabian Placzek, Jürgen Popp, Gregers G. Hermann, Simon Kretschmer, Wolfgang Drexler, Caglar Ataman, Patrick Stein
Publikováno v:
The Analyst
Placzek, F, Cordero Bautista, E, Kretschmer, S, Wurster, L M, Knorr, F, González-Cerdas, G, Erkkilä, M T, Stein, P, Ataman, Ç, Hermann, G G, Mogensen, K, Hasselager, T, Andersen, P E, Zappe, H, Popp, J, Drexler, W, Leitgeb, R A & Schie, I W 2020, ' Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscopy ', Analyst, vol. 145, pp. 1445-1456 . https://doi.org/10.1039/c9an01911a
Placzek, F, Cordero Bautista, E, Kretschmer, S, Wurster, L M, Knorr, F, González-Cerdas, G, Erkkilä, M T, Stein, P, Ataman, Ç, Hermann, G G, Mogensen, K, Hasselager, T, Andersen, P E, Zappe, H, Popp, J, Drexler, W, Leitgeb, R A & Schie, I W 2020, ' Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscopy ', Analyst, vol. 145, pp. 1445-1456 . https://doi.org/10.1039/c9an01911a
Non-muscle-invasive bladder cancer affects millions of people worldwide, resulting in significant discomfort to the patient and potential death. Today, cystoscopy is the gold standard for bladder cancer assessment, using white light endoscopy to dete
Autor:
Roman Nawroth, Richard T. Bryan, Philippe Lamy, Tobias Maurer, Margaret A. Knowles, Gregers G. Hermann, Marc-Oliver Grimm, Ann Taber, Torben Steiniche, Jørgen Bjerggaard Jensen, David J. DeGraff, Francisco X. Real, Karin Mogensen, Joshua I. Warrick, Jay D. Raman, Anshita Goel, Ulrika Segersten, Karin Birkenkamp-Demtröder, Emil Christensen, Clarice S. Groeneveld, Xiaoqi Lin, Joshua J. Meeks, Brian J. Jordan, Núria Malats, Trine Strandgaard, Sia Viborg Lindskrog, Mateo Sokac, Frederik Prip, Gottfrid Sjödahl, Ellen C. Zwarthoff, Tatjana Simic, Iver Nordentoft, Marcus Horstmann, Lasse Maretty, Douglas G. Ward, Dejan Dragicevic, Veronika Weyerer, Carolyn D. Hurst, Aurélien de Reyniès, Kim E.M. van Kessel, Per-Uno Malmström, Astrid Christine Petersen, Arndt Hartmann, Danijel Sikic, Mattias Höglund, Lars Dyrskjøt, Nicolai Juul Birkbak
Publikováno v:
Nature Communications
Lindskrog, S V, Prip, F, Lamy, P, Taber, A, Groeneveld, C S, Birkenkamp-Demtröder, K, Jensen, J B, Strandgaard, T, Nordentoft, I, Christensen, E, Sokac, M, Birkbak, N J, Maretty, L, Hermann, G G, Petersen, A C, Weyerer, V, Grimm, M O, Horstmann, M, Sjödahl, G, Höglund, M, Steiniche, T, Mogensen, K, de Reyniès, A, Nawroth, R, Jordan, B, Lin, X, Dragicevic, D, Ward, D G, Goel, A, Hurst, C D, Raman, J D, Warrick, J I, Segersten, U, Sikic, D, van Kessel, K E M, Maurer, T, Meeks, J J, DeGraff, D J, Bryan, R T, Knowles, M A, Simic, T, Hartmann, A, Zwarthoff, E C, Malmström, P U, Malats, N, Real, F X & Dyrskjøt, L 2021, ' An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer ', Nature Communications, vol. 12, no. 1, 2301 . https://doi.org/10.1038/s41467-021-22465-w
Nature Communications, 12(1):2301. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Lindskrog, S V, Prip, F, Lamy, P, Taber, A, Groeneveld, C S, Birkenkamp-Demtröder, K, Jensen, J B, Strandgaard, T, Nordentoft, I, Christensen, E, Sokac, M, Birkbak, N J, Maretty, L, Hermann, G G, Petersen, A C, Weyerer, V, Grimm, M O, Horstmann, M, Sjödahl, G, Höglund, M, Steiniche, T, Mogensen, K, de Reyniès, A, Nawroth, R, Jordan, B, Lin, X, Dragicevic, D, Ward, D G, Goel, A, Hurst, C D, Raman, J D, Warrick, J I, Segersten, U, Sikic, D, van Kessel, K E M, Maurer, T, Meeks, J J, DeGraff, D J, Bryan, R T, Knowles, M A, Simic, T, Hartmann, A, Zwarthoff, E C, Malmström, P U, Malats, N, Real, F X & Dyrskjøt, L 2021, ' An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer ', Nature Communications, vol. 12, no. 1, 2301 . https://doi.org/10.1038/s41467-021-22465-w
Nature Communications, 12(1):2301. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of patients diagnosed with NMIBC (n = 834).
Publikováno v:
Research and Reports in Urology
Background The aim of this prospective cohort study was to determine the feasibility of incorporating blue light flexible cystoscopy (BLFC) and biopsy/fulguration into routine outpatient follow-up of non-muscle invasive bladder cancer patients. Metho