Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Greg. A. Timblin"'
1
Coenzyme A governs proinflammatory macrophage metabolism
Autor: Greg. A. Timblin, Kevin. M. Tharp, Johanna ten Hoeve, Ilayda Baydemir, Chandra Khantwal, Joshua N. Farahzad, Jorge Domínguez-Andrés, Russell E. Vance, Valerie M. Weaver
The magnitude and duration of Toll-like receptor (TLR)-dependent macrophage proinflammatory responses are tightly regulated. Chronic TLR signaling drives tolerance, an immunosuppressed state of innate immune memory. Understanding of this regulation i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3880129f358f992fcd59e7ee9683e08f
https://doi.org/10.1101/2022.08.30.505732
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2
Coenzyme Q regulates UCP1 expression and thermogenesis through the integrated stress responses
Autor: Ching-Fang Chang, Amanda L. Gunawan, Peter-James H. Zushin, Greg A. Timblin, Ambre M. Bertholet, Biao Wang, Kaoru Sajio, Yuriy Kirichok, Andreas Stahl
Coenzyme Q (CoQ) is an essential component of mitochondrial respiration1 and required for thermogenic activity in brown adipose tissues2 (BAT). CoQ deficiency leads to a wide range of pathological manifestations3 but mechanistic consequences of CoQ d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7db09754882b03e5c9a800ecc7a34f17
https://doi.org/10.1101/2022.03.18.484957
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3
Abstract B003: Reprogramming of fibrotic macrophages to control DCIS progression
Autor: Mary-Kate Hayward, Greg A. Timblin, Jason J. Northey, Connor Stashko, Alastair J. Ironside, E. Shelley Hwang, Valerie M. Weaver
Publikováno v: Cancer Prevention Research. 15:B003-B003
Women with aggressive DCIS are at high risk of progression to invasive breast cancer. Invasive disease is accompanied by extensive collagen remodeling and crosslinking that contributes to tissue fibrosis and stiffness. Fibrotic breast tumors are asso
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22fcd890f184145c596b40fd5cdb23f5
https://doi.org/10.1158/1940-6215.dcis22-b003
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4
Akademický článek
The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination.
Autor: Christian Vettermann, Greg A Timblin, Vivian Lim, Ernest C Lai, Mark S Schlissel
Publikováno v: PLoS ONE, Vol 10, Iss 1, p e0113824 (2015)
V(D)J recombination creates antibody light chain diversity by joining a Vκ gene segment with one of four Jκ segments. Two Jκ germline-transcript (GT) promoters control Vκ-Jκ joining, but the mechanisms that govern Jκ choice are unclear. Here, w
Externí odkaz: https://doaj.org/article/d9f50c6e0728487f9ab7ba5b26fe8918
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6
Mitohormesis reprograms macrophage metabolism to enforce tolerance
Autor: Andreas Stahl, Janet M. Winchenster, Stella Zhu, Jerome Wang, Johanna ten Hoeve, Kevin M. Tharp, Greg A. Timblin, Shannon K. Louie, Rida I. Khan, Daniel K. Nomura, Anthony T. Iavarone, Kaoru Saijo, Breanna Ford
Macrophages generate mitochondrial reactive oxygen and electrophilic species (mtROS, mtRES) as antimicrobials during Toll-like receptor (TLR)-dependent inflammatory responses. Whether mitochondrial stress caused by these molecules impacts macrophage
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87ab4baf899bc5c39b08e0ff38032333
https://doi.org/10.1101/2020.10.20.347443
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7
Mitohormesis reprogrammes macrophage metabolism to enforce tolerance
Autor: Stella Zhu, Kevin M. Tharp, Kaoru Saijo, Breanna Ford, Rida I. Khan, Daniel K. Nomura, Johanna ten Hoeve, Shannon K. Louie, Anthony T. Iavarone, Janet M. Winchester, Greg A. Timblin, Andreas Stahl, Jerome Wang
Publikováno v: Nature metabolism
Macrophages generate mitochondrial reactive oxygen species and mitochondrial reactive electrophilic species as antimicrobials during Toll-like receptor (TLR)-dependent inflammatory responses. Whether mitochondrial stress caused by these molecules imp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a722cb204a7ecc072b30f254d2fa4300
https://pubmed.ncbi.nlm.nih.gov/34075228
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9
Phf15—a novel transcriptional repressor regulating inflammation in mouse microglia
Autor: Marcela K. Preininger, Karou Saijo, Muroy Se, Greg A. Timblin, Cedillo P
AimExcessive microglial inflammation has emerged as a key player in mediating the effects of aging and neurodegeneration on brain dysfunction. Thus, there is great interest in discovering transcriptional repressors that can control this process. We a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22578cc063710ff3106571901be77855
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10
Versatile Histochemical Approach to Detection of Hydrogen Peroxide in Cells and Tissues Based on Puromycin Staining
Autor: Kaoru Saijo, Christopher J. Chang, Clive Yik-Sham Chung, Greg A. Timblin
Publikováno v: Journal of the American Chemical Society, vol 140, iss 19
Yik-Sham Chung, C; Timblin, GA; Saijo, K; & Chang, CJ. (2018). Versatile Histochemical Approach to Detection of Hydrogen Peroxide in Cells and Tissues Based on Puromycin Staining. Journal of the American Chemical Society, 140(19), 6109-6121. doi: 10.1021/jacs.8b02279. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/7g41g1jm
Hydrogen peroxide (H(2)O(2)) is a central reactive oxygen species (ROS) that contributes to diseases from obesity to cancer to neurodegeneration but is also emerging as an important signaling molecule. We now report a versatile histochemical approach
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf3dcc76c950f362f1b923476b50e99
https://escholarship.org/uc/item/7g41g1jm
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