Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Greg deHart"'
Autor:
Kevin Hammon, Greg deHart, Brian R. Vuillemenot, Derek Kennedy, Don Musson, Charles A. O’Neill, Martin L. Katz, Joshua W. Henshaw
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1810-1821 (2021)
Abstract Neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is an ultra‐rare pediatric neurodegenerative disorder characterized by deficiency of the lysosomal enzyme tripeptidyl peptidase‐1 (TPP1). In the absence of adequate TPP1, lysosomal sto
Externí odkaz:
https://doaj.org/article/0b3f82eee32841929b398938b7d967e2
Autor:
Aryun Kim, Anita Grover, Kevin Hammon, Greg deHart, Peter Slasor, Anu Cherukuri, Temitayo Ajayi, David Jacoby, Angela Schulz, Nicola Specchio, Emily deLos Reyes, Paul Gissen, Joshua W. Henshaw
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 635-644 (2021)
Cerliponase alfa is recombinant human tripeptidyl peptidase 1 (TPP1) delivered by i.c.v. infusion for CLN2, a pediatric neurodegenerative disease caused by deficiency in lysosomal enzyme TPP1. We report the pharmacokinetics (PK) and pharmacodynamics
Externí odkaz:
https://doaj.org/article/afb882a5970146d6bafd1acb5b2b22cf
Autor:
Dee Dee Xia, Zena Werb, Paul J. Wolters, Andrew C. Melton, Michael T. Lam, Scott M. Turner, Nabil Azhar, Salman Rahman, Kamran Atabai, Dean Sheppard, Alex J. Kuo, William McKleroy, Claire Emson, Greg DeHart, Sina Jame
Publikováno v:
The Journal of clinical investigation. 119(12)
Milk fat globule epidermal growth factor 8 (Mfge8) is a soluble glycoprotein known to regulate inflammation and immunity by mediating apoptotic cell clearance. Since fibrosis can occur as a result of exaggerated apoptosis and inflammation, we set out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e6472be0886f0eb0a0ced631984be5
https://pubmed.ncbi.nlm.nih.gov/19884654
https://pubmed.ncbi.nlm.nih.gov/19884654