Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Greg Zeikus"'
Autor:
Bradley D. Tait, Susan Elizabeth Hagen, Michael Lovdahl, Eric Andrew Zeikus, Carolyn Nouhan, Joanne Brodfuehrer, Donald Hupe, Christopher Andrew Gajda, John M. Domagala, Greg Zeikus, Elizabeth A. Lunney, Steve Vanderroest, Alexander Pavlovsky, Andrej Urumov, James Saunders, Stephen J. Gracheck, Eric Wise, Tod P. Holler
Publikováno v:
Journal of Medicinal Chemistry. 44:2319-2332
Due largely to the emergence of multi-drug-resistant HIV strains, the development of new HIV protease inhibitors remains a high priority for the pharmaceutical industry. Toward this end, we previously identified a 4-hydroxy-5,6-dihydropyrone lead com
Autor:
J. V. N. Vara Prasad, Donald Hupe, Elizabeth A. Lunney, John M. Domagala, Donna Ferguson, Greg Zeikus, Neil Graham, Peter J. Tummino, Susan Elizabeth Hagen, Caroline Nouhan, Tod P. Holler, Edmund L. Ellsworth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2019-2024
5,6-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease, which bind to the S1, S2, S1', and S2' pockets and have a unique binding mode with the catalytic aspartyl groups and the flap region of the enzyme. Efforts to explore 3-position het
Autor:
Peter J. Tummino, J.V.N. Vara Prasad, Steven VanderRoest, Stephen J. Gracheck, Larry James Markoski, A. Urumov, Joanne Brodfuehrer, Michael Sinz, Donald Hupe, Elizabeth A. Lunney, S V Gulnik, Neil Graham, Alexander Palovsky, James M. Sanders, Edmund L. Ellsworth, John M. Domagala, Christopher Andrew Gajda, Carolyn Nouhan, Susan Elizabeth Hagen, Frederick E. Boyer, Krishna R. Iyer, Tod P. Holler, Greg Zeikus, John W. Erickson, Donna Ferguson, Eric Andrew Zeikus, Bradley D. Tait
Publikováno v:
Journal of medicinal chemistry. 43(5)
On the basis of previous SAR findings and molecular modeling studies, a series of compounds were synthesized which possessed various sulfonyl moieties substituted at the 4-position of the C-3 phenyl ring substituent of the dihydropyran-2-one ring sys
Autor:
John R. Rubin, Neil Graham, Krishna R. Iyer, Steven VanderRoest, Elizabeth A. Lunney, Larry James Markoski, Christopher Andrew Gajda, Bradley D. Tait, James Saunders, Harriet W. Hamilton, Greg Zeikus, John M. Domagala, Stephen J. Gracheck, John W. Erickson, Alexander Pavlovsky, Christine Humblet, Donna Ferguson, J.V.N. Vara Prasad, Eric Andrew Zeikus, Edmund L. Ellsworth, Bruce A. Steinbaugh, Frederick E. Boyer, A. Urumov, Michael Sinz, Donald Hupe, Susan Elizabeth Hagen, Carolyn Nouhan, S V Gulnik, Joanne Brodfuehrer, Tod P. Holler, Peter J. Tummino
Publikováno v:
Bioorganicmedicinal chemistry. 7(12)
With the insight generated by the availability of X-ray crystal structures of various 5,6-dihydropyran-2-ones bound to HIV PR, inhibitors possessing various alkyl groups at the 6-position of 5,6-dihydropyran-2-one ring were synthesized. The inhibitor