Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Greg W. Clark"'
Autor:
Stéphanie Tomé, Kevin Manley, Jodie P Simard, Greg W Clark, Meghan M Slean, Meera Swami, Peggy F Shelbourne, Elisabeth R M Tillier, Darren G Monckton, Anne Messer, Christopher E Pearson
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003280 (2013)
Expansions of trinucleotide CAG/CTG repeats in somatic tissues are thought to contribute to ongoing disease progression through an affected individual's life with Huntington's disease or myotonic dystrophy. Broad ranges of repeat instability arise be
Externí odkaz:
https://doaj.org/article/e0bb9127dfe5406088d109096406ad81
Autor:
Michael Brudno, Viswateja Nelakuditi, Arun K. Ramani, Lauryl M. J. Nutter, Hillary Elrick, Greg W. Clark
Cas-mediated genome editing has enabled researchers to perform mutagenesis experiments with relative ease. Effective genome editing requires tools for guide RNA selection, off-target prediction, and genotyping assay design. While independent tools ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9225ab39a16233983fb534450bde77f
Autor:
Zuyao Ni, Mihail Sarov, Pierre C. Havugimana, Edward M. Marcotte, Julian Kwan, Sadhna Phanse, Ramy H. Malty, Kyle Chessman, Ophelia Papoulas, Xuejian Xiong, Xinghua Guo, Blake Borgeson, Jack Greenblatt, Mohan Babu, John B. Wallingford, John Parkinson, W. Brent Derry, Snejana Stoilova, Alexandr Bezginov, Elisabeth R. M. Tillier, Swati Pal, Daniel R. Boutz, Kevin Drew, Greg W. Clark, Graham L. Cromar, Olga Kagan, Cuihong Wan, Andrew Emili, Fan Tu
Publikováno v:
Data in Brief
Data in Brief, Vol 6, Iss, Pp 715-721 (2016)
Data in Brief, Vol 6, Iss, Pp 715-721 (2016)
Our analysis examines the conservation of multiprotein complexes among metazoa through use of high resolution biochemical fractionation and precision mass spectrometry applied to soluble cell extracts from 5 representative model organisms Caenorhabdi
Autor:
Zuyao Ni, Edward M. Marcotte, W. Brent Derry, Greg W. Clark, Snejana Stoilova, John B. Wallingford, John Parkinson, Alexandr Bezginov, Kevin Drew, Ramy H. Malty, Andrew Emili, Daniel R. Boutz, Blake Borgeson, Elisabeth R. M. Tillier, Fan Tu, Jack Greenblatt, Graham L. Cromar, Mihail Sarov, Kyle Chessman, Olga Kagan, Cuihong Wan, Xinghua Guo, Mohan Babu, Sadhna Phanse, Swati Pal, Xuejian Xiong, Pierre C. Havugimana, Julian Kwan, Ophelia Papoulas
Publikováno v:
Nature
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition
Autor:
Robert L. Charlebois, Elisabeth R. M. Tillier, Vaqaar-un-Nisa Dar, Greg W. Clark, Alexandr Bezginov
Publikováno v:
Molecular Biology and Evolution
Protein interaction networks play central roles in biological systems, from simple metabolic pathways through complex programs permitting the development of organisms. Multicellularity could only have arisen from a careful orchestration of cellular a
Autor:
Elisabeth R. M. Tillier, Valentina Mavisakalyan, Alexander F. Yakunin, Emma R. Master, Alexei Savchenko, Lijun Wang, Greg W. Clark
Publikováno v:
Microbial Biotechnology. 3:677-690
One hundred and seventy-one genes encoding potential esterases from 11 bacterial genomes were cloned and overexpressed in Escherichia coli; 74 of the clones produced soluble proteins. All 74 soluble proteins were purified and screened for esterase ac
Autor:
Elisabeth R. M. Tillier, Greg W. Clark
Publikováno v:
Biochemistry and Cell Biology. 88:185-194
GroEL is a chaperone thought of as essential for bacterial life. However, some species of Mollicutes are missing GroEL. We use phylogenetic analysis to show that the presence of GroEL is polyphyletic among the Mollicutes, and that there is evidence f
Autor:
Elisabeth R. M. Tillier, Robert L. Charlebois, Jinghao M. Yang, Alexandr Bezginov, Vaqaar-un-Nisa Dar, Greg W. Clark
Publikováno v:
Methods in Molecular Biology ISBN: 9781617792755
Bioinformatic methods to predict protein-protein interactions (PPI) via coevolutionary analysis have -positioned themselves to compete alongside established in vitro methods, despite a lack of understanding for the underlying molecular mechanisms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2a2b59303a53ca808bf4e371273285c
https://doi.org/10.1007/978-1-61779-276-2_11
https://doi.org/10.1007/978-1-61779-276-2_11
Publikováno v:
BMC Bioinformatics
Several methods are available for the detection of covarying positions from a multiple sequence alignment (MSA). If the MSA contains a large number of sequences, information about the proximities between residues derived from covariation maps can be