Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Greg Shelley"'
Autor:
Patricia M. Schnepp, Aqila Ahmed, June Escara-Wilke, Jinlu Dai, Greg Shelley, Jill Keller, Atsushi Mizokami, Evan T. Keller
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-14 (2021)
Abstract Background Overcoming drug resistance is critical for increasing the survival rate of prostate cancer (PCa). Docetaxel is the first cytotoxic chemotherapeutical approved for treatment of PCa. However, 99% of PCa patients will develop resista
Externí odkaz:
https://doaj.org/article/d20bcba51bc24959b570b2ddf87858d9
Autor:
Mayara Garcia de Mattos Barbosa, Hui Liu, Daniel Huynh, Greg Shelley, Evan T. Keller, Brian T. Emmer, Emily Sherman, David Ginsburg, Andrew A. Kennedy, Andrew W. Tai, Christiane Wobus, Carmen Mirabeli, Thomas M. Lanigan, Milagros Samaniego, Wenzhao Meng, Aaron M. Rosenfeld, Eline T. Luning Prak, Jeffrey L. Platt, Marilia Cascalho
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Abs that neutralize SARS-CoV-2 are thought to provide the most immediate and effective treatment for those severely afflicted by this virus. Because coronavirus potentially diversifies by mutation, broadly neutralizing Abs are especially sought. Here
Externí odkaz:
https://doaj.org/article/198aea9cddb24432ade981042f42b068
Publikováno v:
Bioengineering, Vol 8, Iss 12, p 212 (2021)
Multiple methods (e.g., small molecules and antibodies) have been engineered to target specific proteins and signaling pathways in cancer. However, many mediators of the cancer phenotype are unknown and the ability to target these phenotypes would he
Externí odkaz:
https://doaj.org/article/4a9f7ddffa154f15acc832d5e8a4ecef
Integrins that contain an integrin αV subunit contribute to multiple functions that promote cancer progression. The goal of this study was to determine whether abituzumab (DI17E6, EMD 525797), a humanized monoclonal antibody (mAb) against integrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b05d5f716c532070006d665e283be532
https://doi.org/10.1158/1541-7786.c.6540057.v1
https://doi.org/10.1158/1541-7786.c.6540057.v1
Supplemental Figure 1. Anti-Integrin alphaV antibody EPR16800 inhibits prostate cancer motility and invasiveness. Supplemental Figure 2. Anti-Integrin alphaV antibody EPR16800 inhibits expression of alphaV integrin and phosphorylation of FAK, Akt and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419e2dde521861b4b6155ed552b5a42d
https://doi.org/10.1158/1541-7786.22511856
https://doi.org/10.1158/1541-7786.22511856
Autor:
Evan T. Keller, Atsushi Mizokami, Hui Jiang, Nicole Wakim, Jinlu Dai, Greg Shelley, Patricia M. Schnepp
Supplementary Table 1: Differential Gene Expression Analysis in Individual Cell Lines Supplementary Table 2: Genes and ranking based on their single cell expression with probability (Q value) for DU145 resistant versus sensitive cells. Supplementary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15cd4d1984a928f127b386f22d9ad87
https://doi.org/10.1158/1541-7786.22517016.v1
https://doi.org/10.1158/1541-7786.22517016.v1
Autor:
Allison May, Claire Williams, Stephanie The, Sean Kim, Nathan Schurman, Greg Shelley, Tyler Robinson, Simpa Salami, Rohit Mehra, Aaron Udager, Evan Keller
Publikováno v:
Journal of Urology. 209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5161c672dda8357a230de8680d89fef8
https://doi.org/10.1097/ju.0000000000003272.12
https://doi.org/10.1097/ju.0000000000003272.12
Publikováno v:
Cancer Systems and Integrative Biology ISBN: 9781071631621
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1db5b9fd483afec8071f8001646b52e
https://doi.org/10.1007/978-1-0716-3163-8_7
https://doi.org/10.1007/978-1-0716-3163-8_7
Autor:
Allison May, Claire Williams, Stephanie The, Sean Kim, Nathan Schurman, Greg Shelley, Tyler Robinson, Simpa Salami, Rohit Mehra, Aaron Udager, Evan Keller
Publikováno v:
Cancer Research. 83:4700-4700
Background: Sarcomatoid renal cell carcinoma (sRCC) is thought to arise by epithelial to mesenchymal transition (EMT) of the parental tumor in diverse RCC including clear cell RCC (ccRCC). sRCC is also known to be highly immunogenic and also express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81f457d62fa2cf6c9d6adbb82a1520ce
https://doi.org/10.1158/1538-7445.am2023-4700
https://doi.org/10.1158/1538-7445.am2023-4700
Autor:
Evan T. Keller, Nicole I Wakim, Patricia M. Schnepp, Atsushi Mizokami, Jinlu Dai, Hui Jiang, Greg Shelley
Publikováno v:
Mol Cancer Res
The majority of patients with prostate cancer treated with docetaxel develop resistance to it. To better understand the mechanism behind the acquisition of resistance, we conducted single-cell RNA-sequencing (scRNA-seq) of docetaxel-sensitive and -re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174bd12f506955b49ca7f0d3fcc0136b
https://doi.org/10.1158/1541-7786.mcr-20-0051
https://doi.org/10.1158/1541-7786.mcr-20-0051