Racial Differences in Accuracy of Predictive Models for High-Flow Nasal Cannula Failure in COVID-19

Autor: Philip Yang, MD, MSc, Ismail A. Gregory, MD, Chad Robichaux, MPH, Andre L. Holder, MD, MSc, Greg S. Martin, MD, MSc, Annette M. Esper, MD, MSc, Rishikesan Kamaleswaran, PhD, Judy W. Gichoya, MD, Sivasubramanium V. Bhavani, MD, MS

Publikováno v: Critical Care Explorations, Vol 6, Iss 3, p e1059 (2024)

OBJECTIVES:. To develop and validate machine learning (ML) models to predict high-flow nasal cannula (HFNC) failure in COVID-19, compare their performance to the respiratory rate-oxygenation (ROX) index, and evaluate model accuracy by self-reported r

Externí odkaz: https://doaj.org/article/aa8b5228a84e4813b909d5b356f7c8ec

Discovery of phytochelatins in human urine: Evidence for function in selenium disposition and protection against cadmium

Autor: Zachery R. Jarrell, Ken H. Liu, Kristine K. Dennis, Xin Hu, Greg S. Martin, Dean P. Jones, Young‐Mi Go

Publikováno v: FASEB BioAdvances, Vol 5, Iss 9, Pp 367-375 (2023)

Abstract This report identifies, for the first time, a phytochelatin compound, phytochelatin 2 [γ‐E‐C‐γ‐E‐C‐G], and related metabolites in human urine. Phytochelatins are metal‐binding peptides produced by plants. They are present in

Externí odkaz: https://doaj.org/article/25583d44d3b34d91871d900b2accaf87

Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis

Autor: Patrick R. Lawler, MD, MPH, Garen Manvelian, PhD, Alida Coppi, PhD, Amy Damask, PhD, Michael N. Cantor, MD, Manuel A. R. Ferreira, PhD, Charles Paulding, PhD, Nilanjana Banerjee, PhD, Dadong Li, PhD, Susan Jorgensen, MS, Richa Attre, PhD, David J. Carey, PhD, Kristi Krebs, PhD, Lili Milani, PhD, Kristian Hveem, MD, Jan K. Damås, PhD, Erik Solligård, PhD, Stefan Stender, MD, Anne Tybjærg-Hansen, MD, Børge G. Nordestgaard, MD, Tamara Hernandez-Beeftink, PhD, Tormod Rogne, MD, Carlos Flores, PhD, Jesús Villar, MD, Keith R. Walley, MD, Vincent X. Liu, MD, Alison E. Fohner, PhD, Luca A. Lotta, MD, Christos A. Kyratsous, PhD, Mark W. Sleeman, PhD, Michel Scemama, MD, Richard DelGizzi, MS, Robert Pordy, MD, Julie E. Horowitz, PhD, Aris Baras, MD, Greg S. Martin, MD, Philippe Gabriel Steg, MD, Gregory G. Schwartz, MD, Michael Szarek, PhD, Shaun G. Goodman, MD

Publikováno v: Critical Care Explorations, Vol 5, Iss 11, p e0997 (2023)

OBJECTIVES:. Treatments that prevent sepsis complications are needed. Circulating lipid and protein assemblies—lipoproteins play critical roles in clearing pathogens from the bloodstream. We investigated whether early inhibition of proprotein conve

Externí odkaz: https://doaj.org/article/9668af2bf04b4033991c97345adef80d

Timely Albumin Improves Survival in Patients With Cirrhosis on Diuretic Therapy Who Develop Acute Kidney Injury: Real-World Evidence in the United States

Autor: Ray W. Kim, Karthik Raghunathan, Greg S. Martin, E. Anne Davis, Navreet S. Sindhwani, Santosh Telang, Kunal Lodaya

Publikováno v: Gastro Hep Advances, Vol 2, Iss 2, Pp 252-260 (2023)

Background and Aims: Patients admitted with decompensated cirrhosis who develop acute kidney injury (AKI) tend to experience poor outcomes, even if provided with increased organ support such as renal replacement therapies. We assessed the association

Externí odkaz: https://doaj.org/article/ff6b444919f54ccaa06c025a6d6b339d

Implementation of a Virtual Interprofessional ICU Learning Collaborative: Successes, Challenges, and Initial Reactions From the Structured Team-Based Optimal Patient-Centered Care for Virus COVID-19 Collaborators

Autor: Simon Zec, MD, Nika Zorko Garbajs, MD, Yue Dong, MD, Ognjen Gajic, MD, Christina Kordik, MA, Lori Harmon, RRT, MBA, CPHQ, Marija Bogojevic, MD, Romil Singh, MD, Yuqiang Sun, MD, Vikas Bansal, MD, Linh Vu, MD, Kelly Cawcutt, MD, John M. Litell, DO, Sarah Redmond, PhD, Eleanor Fitzpatrick, RN, Kirstin J. Kooda, PharmD, Michelle Biehl, MD, Neha S. Dangayach, MD, Viren Kaul, MD, June M. Chae, MD, Aaron Leppin, MD, Mathew Siuba, MD, Rahul Kashyap, MBBS, Allan J. Walkey, MD, Alexander S. Niven, MD, on behalf of the Structured Team-based Optimal Patient-Centered Care for Virus COVID-19 (STOP-VIRUS) Collaborative, Anthony Martinez, MD, Dean Meadows, MD, Helen Stinnett, BA, RRT, Michael Allison, MD, Olubukola Adeyemi, PharmD, Terry Herbert, BSN, RN, Gerald L. Weinhouse, MD, Namrata Patil, MD, MPH, Gaspar Hacobian, PharmD, BCPS, Kamen Rangelov, MD, Jillian Parker, RRT, Michael P. Smith, PharmD, BCCCP, Rachel Smith, RN, MSN, MBA, CCRN, Eliza Deery, MD, Andrea Harper, MS, Emily Davis, RN, CCRN, Grace M. Arteaga, MD, FAAP, FCCM, Jennifer L. Fleegel, RN, CCRN, Julie M. Duncan, RN, Kevin K. Graner, RPh, Tammy J. Schultz, RRT, LRT, Abhishek Giri, MBBS, Ashley Gill, RRT, Catherine L. Mielke, MS, APRN, CNS, Devang Sanghavi, MD, MHA, Jonathan K. Clark, RRT, Julie Shimp, RN, Lisa Marshall, MSN, RN, Michael Spiros, MSN, RN, Nirmaljot Kaur, MD, Sean P. Kiley, MD, Siva Naga Yarrarapu, MBBS, Teresa Keister, RN, Gage Stroope, LRT, CRT, Jackie Stark, PharmD, BCPS, Jessica Poehler, RN, Juan Pablo, Domecq Garces, MD, Nitesh Kumar Jain, MD, MBBS, Syed Anjum Khan, MD, Thoyaja Koritala, MD, Abigail La Nou, MD, FACEP, Christina Hall, MS, RN, Cindy Christensen, MSN, RN, FNP-BC, Kirsten Holbrook, RRT, Sara Toufar, PharmD, RPh, Sarah Normand, PharmD, RPh, Amy Spitzner, RN, CCRN, Carissa Quinn, APRN, CNS, DNP, Christina Xia, PharmD, BCCCP, Holly D. Behrns, LRT, RRT, Erin Barreto, PharmD, RPh, Jennifer Elmer, APRN, CNS, DNP, Sarah Chalmers, MD, PCCM, Macy Cooper, RN, Aaron Harthan, PharmD, BCPPS, Edmundo A. Martinez, MD, Jennifer A. Bandy, RN, BSN, John Sanford, RRT-ACCS, RRT-NPS, Jackie A. Guiliani, BSRT, RRT-NPS, Megan Kupferschmid, MSN, RN, P-CCRN, Anand Pariyadath, MD, Brandy Vitielliss, BSN, RN, Daniel Temas, MD, Smith F. Heavner, MS, RN, PCCN, Amanda Frary, MSN, RN, Murtaza Akhter, MD, Rania Rahman, MD, Mary Mulrow, RN, MN, CCRP, Tracy Cooper, RN, John M. Litell, DO, FACEP, June Mee Chae, MD, Kelly Cawcutt, MD, MS, FACP, FIDSA, Kirstin J. Kooda, PharmD, RPh, Neha S. Dangayach, MD, MSCR, Matthew Siuba, DO, Aaron B. Holley, MD, Alexander A. Kon, MD, MS, Amita Avadhani, PhD, DNP, CNE, DCC, ACNP-BC, NP-C, CCRN, FAANP, FCCM, Amy L. Dzierba, PharmD, FCCP, BCCCP, FCCM, Andre C. Kalil, MD, MPH, FACP, Ashley D. DePriest, MS, RDN, CNSC, Bradley Peters, PharmD, RPh, BCSP, BCCCP, Brenda T. Pun, DNP, RN, FCCM, Courtney E. Bennett, DO, Eric Kriner, BS, RRT, Erin S. DeMartino, MD, Erin Strong, BSN, RN, CCRN, Giora Netzer, MD, Greg S. Martin, MD, MSc, FCCM, Jerry J. Zimmerman, MD, PhD, FCCM, Julia Taylor, MD, MA, HEC-C, Karen A. Korzick, MD, MA, FCCP, FACP, FCCM, Katherine Fischkoff, MD, MPA, FACS, Lewis J. Kaplan, MD, FACS, FCCM, Marlies Ostermann, MD, PhD, Mary Susan Gaeta, MD, FACP, Mary Faith Marshall, HEC-C, PhD, Nahreen Ahmed, MD, MPH, Paul Alan Nyquist, MD, MPH, Pooja A. Nawathe, MD, FAAP, CHSE-A, CHSOS, FCCM, Preeti R. John, MD, MPH, FACS, CPE, HEC-C, Uzma Syed, DO, FIDSA

Publikováno v: Critical Care Explorations, Vol 5, Iss 6, p e0922 (2023)

IMPORTANCE:. Initial Society of Critical Care Medicine Discovery Viral Infection and Respiratory illness Universal Study (VIRUS) Registry analysis suggested that improvements in critical care processes offered the greatest modifiable opportunity to i

Externí odkaz: https://doaj.org/article/4925a92e6b274670b7370ea7c82b451b