Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Greg R. Collier"'
Autor:
Liam G. Hall, Juliane K. Czeczor, Timothy Connor, Javier Botella, Kirstie A. De Jong, Mark C. Renton, Amanda J. Genders, Kylie Venardos, Sheree D. Martin, Simon T. Bond, Kathryn Aston-Mourney, Kirsten F. Howlett, James A. Campbell, Greg R. Collier, Ken R. Walder, Matthew McKenzie, Mark Ziemann, Sean L. McGee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. The role of amyloid beta 42 (Aβ42) in these diverse chronic diseases is obscure. Here we show that adipose tissue
Externí odkaz:
https://doaj.org/article/ade282758ba44938be3e4d25c0c6bdc1
Autor:
Liam G Hall, Juliane K. Czeczor, Timothy Connor, Javier Botella, Kirstie A. De Jong, Mark C. Renton, Amanda J. Genders, Kylie Venardos, Sheree D. Martin, Simon T. Bond, Kathryn Aston-Mourney, Kirsten F. Howlett, James A Campbell, Greg R. Collier, Ken R. Walder, Matthew McKenzie, Mark Ziemann, Sean L. McGee
There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. While some common aetiological mechanisms are known, the role of amyloid beta 42 (Aβ42) in these diverse chronic diseases i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7713650f077407ca0d354131f4b65baa
https://doi.org/10.1101/2022.10.02.510555
https://doi.org/10.1101/2022.10.02.510555
Autor:
Melanie A. Carless, Greg R. Collier, Hemant Kulkarni, Vincent P. Diego, Shelley A. Cole, Ken Walder, Joanne E. Curran, Thomas D. Dyer, Harald H H Göring, John Blangero
Publikováno v:
Cancer Chemotherapy and Pharmacology. 71:1095-1100
The role of v-ATPases in cancer biology is being increasingly recognized. Yeast studies indicate that the tyrosine kinase inhibitor imatinib may interact with the v-ATPase genes and alter the course of cancer progression. Data from humans in this reg
Autor:
Joanne Pagnon, Nicholas R.F. Hannan, Ken Walder, Helen C. Feng, Yuan Gao, Greg R. Collier, Jeremy B. M. Jowett, Stephen Wanyonyi, Kee-Hong Kim, Nicky Konstantopolous
Publikováno v:
Cytokine. 33:246-251
SEPS1 (also called selenoprotein S, SelS) plays an important role in the production of inflammatory cytokines and its expression is activated by endoplasmic reticulum (ER) stress. In this report, we have identified two binding sites for the nuclear f
Autor:
Anthony G. Comuzzie, Greg R. Collier, Paul Zimmet, Jeremy B. M. Jowett, John Blangero, Ken Walder, Kiymet Bozaoglu, Thomas D. Dyer, John L. VandeBerg, Joanne E. Curran, David L. Rainwater, Jean W. MacCluer, Kate S. Elliott
Publikováno v:
Human Biology. 78:147-159
The BEACON gene was initially identified using the differential display polymerase chain reaction on hypothalamic mRNA samples collected from lean and obese Psammomys obesus, a polygenic animal model of obesity. Hypothalamic BEACON gene expression wa
Autor:
Jeremy B. M. Jowett, Guowen Cai, Yuan Gao, Kate S. Elliott, Greg R. Collier, Ahmed H. Kissebah, Ken Walder, Jianmin Wang, Jean W. MacCluer, Dalia M Abel Azim, John Blangero, P. Z. Zimmet, Thomas D. Dyer, Michael C. Mahaney, Joanne E. Curran, Anthony G. Comuzzie, Kristi Gluschenko
Publikováno v:
Nature Genetics. 37:1234-1241
Chronic inflammation has a pathological role in many common diseases and is influenced by both genetic and environmental factors. Here we assess the role of genetic variation in selenoprotein S (SEPS1, also called SELS or SELENOS), a gene involved in
Autor:
Matthew Prior, Scott Lee, Adrian Cooper, Michael W. Schwartz, K. Whitecross, Kristy Bolton, Gregory J. Morton, Victoria C. Foletta, R. Fahey, Greg R. Collier, Janine McMillan, James L. Trevaskis, Ken Walder, Lyndal Kerr-Bayles
Publikováno v:
Endocrinology. 146:3757-3764
To identify genes involved in the central regulation of energy balance, we compared hypothalamic mRNA from lean and obese Psammomys obesus, a polygenic model of obesity, using differential display PCR. One mRNA transcript was observed to be elevated
Publikováno v:
Frontiers in Medicinal Chemistry - Online. 2:161-182
New treatments are currently required for the common metabolic diseases obesity and type 2 diabetes. The identification of physiological and biochemical factors that underlie the metabolic disturbances observed in obesity and type 2 diabetes is a key
Autor:
Terry Sunderland, Yuan Gao, Greg R. Collier, Natalie Bishara, Helen C. Feng, Melissa Quick, Ken Walder, Kristy Bolton, Lakshmi Kantham
Publikováno v:
FEBS Letters. 563:185-190
SelS is a newly identified selenoprotein and its gene expression is up-regulated in the liver of Psammomys obesus after fasting. We have examined whether SelS is regulated by glucose deprivation and endoplasmic reticulum (ER) stress in HepG2 cells. G
Publikováno v:
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 137:65-73
The hypothalamus is a key central controller of energy homeostasis and is the source and/or site of action of many neuropeptides involved in this process. The aim of this study was to isolate hypothalamic genes differentially expressed between lean a